SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4qbr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 CYH A 540
ARG A 476
CYH A 559
 ZN  A 702 (-2.4A)
ZN  A 702 ( 4.8A)
ZN  A 702 (-2.2A)
 1.11A 1p9gA-4qbrA:
undetectable		 1p9gA-4qbrA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4qbr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		4 / 7 PHE A 609
PHE A 521
THR A 538
LEU A 508
 None
 0.94A 3t3sC-4qbrA:
undetectable		 3t3sC-4qbrA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 4qbr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A
(Homo
sapiens) 		3 / 3 ARG A 488
ARG A 478
ARG A 476
 None
None
ZN  A 702 ( 4.8A)
 0.83A 5vcgA-4qbrA:
undetectable		 5vcgA-4qbrA:
12.18