SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		4 / 4 LEU A 174
GLY A  97
ASP A  99
TYR A  86
 None
None
KAN  A 201 ( 3.9A)
None
 1.29A 1oxrA-4qc6A:
undetectable		 1oxrA-4qc6A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BUE_A_RIOA1201_0
(AAC(6')-IB)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		6 / 11 GLY A  35
TYR A  50
GLN A  74
TYR A  76
ASP A  99
ASP A 136
 FMT  A 203 ( 3.5A)
KAN  A 201 ( 3.9A)
KAN  A 201 (-3.1A)
None
KAN  A 201 ( 3.9A)
KAN  A 201 (-3.8A)
 0.91A 2bueA-4qc6A:
20.0		 2bueA-4qc6A:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		4 / 8 TYR A  96
GLU A  57
PHE A  59
VAL A 133
 None
 0.89A 2fl5E-4qc6A:
undetectable
2fl5F-4qc6A:
undetectable		 2fl5E-4qc6A:
20.44
2fl5F-4qc6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		6 / 12 GLY A  35
TYR A  50
GLN A  74
TYR A  76
ASP A  99
ASP A 136
 FMT  A 203 ( 3.5A)
KAN  A 201 ( 3.9A)
KAN  A 201 (-3.1A)
None
KAN  A 201 ( 3.9A)
KAN  A 201 (-3.8A)
 0.87A 2vqyA-4qc6A:
20.1		 2vqyA-4qc6A:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		5 / 8 LEU A 124
ILE A 117
TYR A 148
PHE A 153
GLN A 100
 None
None
30N  A 202 (-4.5A)
None
None
 1.28A 2weyB-4qc6A:
undetectable		 2weyB-4qc6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		4 / 6 GLY A  97
GLN A 100
ILE A 134
VAL A 133
 None
 1.17A 3kvvA-4qc6A:
undetectable		 3kvvA-4qc6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		4 / 6 GLY A  97
GLN A 100
ILE A 134
VAL A 133
 None
 1.16A 3kvvB-4qc6A:
undetectable		 3kvvB-4qc6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		5 / 12 ILE A  70
ILE A 112
VAL A  30
LEU A  25
MET A  21
 None
30N  A 202 (-4.9A)
None
FMT  A 203 ( 4.4A)
None
 0.98A 3s79A-4qc6A:
undetectable		 3s79A-4qc6A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		5 / 12 LEU A 135
VAL A 133
TYR A  34
TYR A  50
GLY A  73
 None
None
KAN  A 201 ( 3.6A)
KAN  A 201 ( 3.9A)
None
 1.42A 5i8fA-4qc6A:
undetectable		 5i8fA-4qc6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		5 / 12 ILE A  70
ILE A 112
VAL A  30
LEU A  25
MET A  21
 None
30N  A 202 (-4.9A)
None
FMT  A 203 ( 4.4A)
None
 0.96A 5jkvA-4qc6A:
undetectable		 5jkvA-4qc6A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		3 / 3 TYR A  34
TYR A  76
GLN A  74
 KAN  A 201 ( 3.6A)
None
KAN  A 201 (-3.1A)
 0.92A 5jsdA-4qc6A:
undetectable
5jsdB-4qc6A:
undetectable		 5jsdA-4qc6A:
12.33
5jsdB-4qc6A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		3 / 3 TYR A  34
TYR A  76
GLN A  74
 KAN  A 201 ( 3.6A)
None
KAN  A 201 (-3.1A)
 0.92A 5jsdB-4qc6A:
undetectable
5jsdC-4qc6A:
undetectable		 5jsdB-4qc6A:
12.33
5jsdC-4qc6A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4qc6 BIFUNCTIONAL AAC/APH
(Staphylococcus
warneri) 		4 / 6 ARG A 128
PHE A 121
PHE A 123
ILE A  75
 None
 1.16A 5vceA-4qc6A:
undetectable		 5vceA-4qc6A:
14.85