SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 LEU A 117
TRP A 114
PHE A 124
VAL A 484
 None
 1.33A 1ibgH-4qc8A:
undetectable		 1ibgH-4qc8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 8 ARG A 125
HIS A 532
ARG A 123
VAL A 484
 None
 1.36A 1u1jA-4qc8A:
undetectable		 1u1jA-4qc8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		5 / 7 TRP A 189
GLY A 474
THR A 473
PHE A 100
PHE A 102
 None
 1.46A 2qx4A-4qc8A:
undetectable
2qx4B-4qc8A:
undetectable		 2qx4A-4qc8A:
17.93
2qx4B-4qc8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 TRP A 189
GLY A 474
PHE A 100
PHE A 102
 None
 1.04A 2qx6A-4qc8A:
undetectable
2qx6B-4qc8A:
undetectable		 2qx6A-4qc8A:
17.93
2qx6B-4qc8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 VAL A 131
MET A 181
ARG A  64
THR A  51
 None
 1.37A 2x2iA-4qc8A:
undetectable		 2x2iA-4qc8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		3 / 3 CYH A 163
PHE A 452
PHE A 162
 None
 0.93A 3cr5X-4qc8A:
undetectable		 3cr5X-4qc8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 7 VAL A 476
MET A 159
ILE A 453
ILE A 451
 None
 0.90A 3hgxA-4qc8A:
undetectable		 3hgxA-4qc8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		3 / 3 ARG A 337
THR A 342
THR A 325
 None
 0.79A 3k2hB-4qc8A:
undetectable		 3k2hB-4qc8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		5 / 12 PHE A 530
ASN A 254
HIS A 533
ALA A 376
ASN A 522
 None
 1.23A 3v3oB-4qc8A:
undetectable		 3v3oB-4qc8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		5 / 12 GLY A 158
ILE A  70
ILE A 453
VAL A 133
ILE A 451
 None
 1.00A 4q5mA-4qc8A:
undetectable		 4q5mA-4qc8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 TRP A 189
GLY A 474
PHE A 100
PHE A 102
 None
 1.00A 4qogA-4qc8A:
undetectable
4qogB-4qc8A:
undetectable		 4qogA-4qc8A:
17.66
4qogB-4qc8A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 TYR A 169
GLU A 226
TYR A  76
LEU A 222
 None
 1.07A 4twdB-4qc8A:
undetectable
4twdC-4qc8A:
undetectable		 4twdB-4qc8A:
20.00
4twdC-4qc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 TYR A  76
ASN A  72
GLU A 226
TYR A 194
 None
 1.14A 4twdG-4qc8A:
undetectable
4twdH-4qc8A:
undetectable		 4twdG-4qc8A:
20.00
4twdH-4qc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 6 TYR A  76
ASN A  72
GLU A 226
TYR A 196
 None
 1.44A 4twdG-4qc8A:
undetectable
4twdH-4qc8A:
undetectable		 4twdG-4qc8A:
20.00
4twdH-4qc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 7 PRO A 415
GLU A 374
TRP A 250
ASP A 247
 None
 1.19A 4uacA-4qc8A:
undetectable		 4uacA-4qc8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 5 ALA A 519
ARG A 418
ALA A 517
GLU A 183
 None
 1.23A 5a06C-4qc8A:
undetectable
5a06D-4qc8A:
undetectable		 5a06C-4qc8A:
18.86
5a06D-4qc8A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		4 / 8 GLY A  50
ARG A  64
GLN A 475
TYR A 134
 None
 0.93A 5vlmB-4qc8A:
undetectable		 5vlmB-4qc8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		5 / 12 GLY A 347
GLY A 302
THR A 433
LYS A 432
ASP A 436
 None
 1.03A 5wz1G-4qc8A:
undetectable		 5wz1G-4qc8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4qc8 VP2
(Ungulate
bocaparvovirus
1) 		5 / 12 THR A 239
VAL A 133
VAL A 476
PHE A 241
PHE A 102
 None
 1.41A 6iblA-4qc8A:
undetectable		 6iblA-4qc8A:
20.99