SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 PHE A  61
GLY A  63
SER A  64
THR A  71
ASN A  52
 None
 1.20A 1g60A-4qciA:
undetectable		 1g60A-4qciA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 ASP A  84
LYS A 102
PRO A   7
GLY A  98
LEU A   4
 None
 1.28A 2nv4A-4qciA:
undetectable		 2nv4A-4qciA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 SER A 184
HIS A 185
THR A 178
LEU A 177
 None
 1.20A 3arrA-4qciA:
6.5		 3arrA-4qciA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 THR A 112
SER A 135
PHE A 116
 None
 0.70A 3d4sA-4qciA:
undetectable		 3d4sA-4qciA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ASN A 167
ASN A 136
GLU A 165
 None
 0.92A 3kpdC-4qciA:
undetectable		 3kpdC-4qciA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		5 / 11 ASP A  81
LEU A 103
VAL A  12
ALA A  13
THR A  77
 None
 1.38A 3n23C-4qciA:
undetectable		 3n23C-4qciA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		5 / 9 THR A  77
GLN A  36
GLU A  80
LEU A  72
ILE A  20
 None
 1.35A 3nbqA-4qciA:
undetectable		 3nbqA-4qciA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 PHE A 169
LYS A 102
SER A   9
 None
 0.91A 3tyeB-4qciA:
undetectable		 3tyeB-4qciA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 SER A 202
SER A 204
SER A 187
THR A 189
 None
 0.79A 4iklA-4qciA:
undetectable
4iklB-4qciA:
undetectable		 4iklA-4qciA:
22.27
4iklB-4qciA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ASP A  50
LEU A  27
GLY A  28
 None
 0.52A 4xmfA-4qciA:
undetectable		 4xmfA-4qciA:
23.15