SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 10 VAL A 288
VAL A 345
VAL A 296
ASN A 364
LEU A 312
 None
 1.23A 1fe2A-4qdhA:
undetectable		 1fe2A-4qdhA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 PHE A 121
VAL A  92
ILE A  88
SER A 133
LEU A 115
 None
 1.10A 1fm4A-4qdhA:
undetectable		 1fm4A-4qdhA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A  83
LEU A 108
LEU A 132
LEU A 100
CYH A  80
 None
 1.29A 1sqnA-4qdhA:
undetectable		 1sqnA-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 113
LEU A 132
ASN A 135
LEU A 162
LEU A 106
 None
 1.45A 1sqnA-4qdhA:
undetectable		 1sqnA-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 LEU A 283
ASN A 315
ILE A 293
LEU A 272
PHE A 301
 None
 1.32A 1tw4A-4qdhA:
undetectable		 1tw4A-4qdhA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		4 / 5 LEU A 256
LEU A 228
LEU A 201
MET A 190
 None
 1.06A 2oaxF-4qdhA:
undetectable		 2oaxF-4qdhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 ILE A 293
LEU A 264
LEU A 262
PHE A 301
 None
 0.83A 2vctA-4qdhA:
undetectable		 2vctA-4qdhA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 ILE A 293
LEU A 264
LEU A 262
PHE A 301
 None
 0.87A 2vctB-4qdhA:
undetectable		 2vctB-4qdhA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 113
LEU A 132
ASN A 135
LEU A 162
LEU A 106
 None
 1.44A 2w8yB-4qdhA:
undetectable		 2w8yB-4qdhA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A  83
LEU A 108
LEU A 132
LEU A 100
CYH A  80
 None
 1.25A 3d90A-4qdhA:
undetectable		 3d90A-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 113
LEU A 132
ASN A 135
LEU A 162
LEU A 106
 None
 1.41A 3d90A-4qdhA:
undetectable		 3d90A-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A  83
LEU A 108
LEU A 132
LEU A 100
CYH A  80
 None
 1.23A 3d90B-4qdhA:
undetectable		 3d90B-4qdhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 277
VAL A 329
GLY A 326
LEU A 272
ILE A 293
 None
 1.11A 3ijdB-4qdhA:
undetectable		 3ijdB-4qdhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 LEU A 272
LEU A 312
SER A 290
ASN A 291
 None
None
NAG  A 505 ( 3.2A)
None
 1.02A 3lm8B-4qdhA:
undetectable
3lm8D-4qdhA:
undetectable		 3lm8B-4qdhA:
18.65
3lm8D-4qdhA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		3 / 3 ASP A 287
GLU A 334
SER A 216
 NAG  A 505 ( 4.6A)
NAG  A 505 ( 4.5A)
None
 0.63A 3p2kA-4qdhA:
undetectable		 3p2kA-4qdhA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 ILE A  67
PHE A 121
PHE A 148
LEU A 175
TYR A 116
 None
 1.24A 4j03A-4qdhA:
undetectable		 4j03A-4qdhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 175
LEU A 215
ASN A 218
GLY A 189
PHE A 148
 None
 1.08A 4pgfA-4qdhA:
undetectable		 4pgfA-4qdhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 PHE A 300
ILE A 293
LEU A 269
LEU A 283
LEU A 286
 None
 1.27A 4qynB-4qdhA:
undetectable		 4qynB-4qdhA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 PRO A 232
LEU A 207
LEU A 240
ASN A 230
LEU A 213
 None
 1.40A 5emlA-4qdhA:
undetectable		 5emlA-4qdhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 ASN A 315
ASN A 340
LEU A 312
ASN A 311
GLY A 266
 None
None
None
NAG  A 505 (-1.9A)
None
 1.10A 6dwnA-4qdhA:
undetectable		 6dwnA-4qdhA:
11.78