SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		3 / 3 TRP A 578
ALA A 519
VAL A 521
 None
 0.93A 1bdwA-4qdrA:
undetectable
1bdwB-4qdrA:
undetectable		 1bdwA-4qdrA:
4.42
1bdwB-4qdrA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 12 ALA A 519
GLY A 505
ALA A 517
ILE A 583
SER A 579
 None
 1.13A 1ve3A-4qdrA:
undetectable		 1ve3A-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 12 ALA A 519
GLY A 505
ALA A 517
ILE A 583
SER A 579
 None
 1.11A 1ve3B-4qdrA:
undetectable		 1ve3B-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		4 / 6 ARG A 522
GLU A 576
PRO A 483
ALA A 481
 None
 1.32A 2ejfB-4qdrA:
undetectable		 2ejfB-4qdrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 12 HIS A 554
ALA A 519
GLY A 505
ASP A 556
GLY A 508
 None
 1.15A 2f8lA-4qdrA:
undetectable		 2f8lA-4qdrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		3 / 3 LEU A 587
MET A 440
MET A 338
 None
 1.03A 2vavF-4qdrA:
undetectable		 2vavF-4qdrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		3 / 3 PRO A 546
PHE A 563
LYS A 547
 None
 1.27A 3bjwG-4qdrA:
undetectable		 3bjwG-4qdrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		3 / 3 PRO A 575
PHE A 549
LYS A 523
 None
 1.25A 3bjwG-4qdrA:
undetectable		 3bjwG-4qdrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 11 LEU A 467
ALA A 465
GLY A 439
SER A 463
SER A 469
 None
 1.02A 3gyqB-4qdrA:
undetectable		 3gyqB-4qdrA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.78A 3k4vD-4qdrA:
undetectable		 3k4vD-4qdrA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 518
VAL A 468
THR A 367
 None
 0.78A 3ndtA-4qdrA:
undetectable		 3ndtA-4qdrA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 12 ASP A 301
THR A 298
THR A 305
GLN A 308
ASP A 315
 None
 1.30A 4ng6A-4qdrA:
undetectable		 4ng6A-4qdrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.27A 4yb6A-4qdrA:
undetectable
4yb6E-4qdrA:
undetectable		 4yb6A-4qdrA:
21.43
4yb6E-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.27A 4yb6B-4qdrA:
undetectable
4yb6C-4qdrA:
undetectable		 4yb6B-4qdrA:
21.43
4yb6C-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 GLY A 500
GLU A 588
VAL A 498
LEU A 587
LEU A 492
 None
 1.27A 4yb6C-4qdrA:
undetectable
4yb6F-4qdrA:
undetectable		 4yb6C-4qdrA:
21.43
4yb6F-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.26A 4yb6A-4qdrA:
undetectable
4yb6D-4qdrA:
undetectable		 4yb6A-4qdrA:
21.43
4yb6D-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.28A 4yb6D-4qdrA:
undetectable
4yb6E-4qdrA:
undetectable		 4yb6D-4qdrA:
21.43
4yb6E-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 LEU A 587
LEU A 492
GLY A 500
GLU A 588
VAL A 498
 None
 1.29A 4yb6B-4qdrA:
undetectable
4yb6F-4qdrA:
undetectable		 4yb6B-4qdrA:
21.43
4yb6F-4qdrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
 0.88A 5flcB-4qdrA:
undetectable		 5flcB-4qdrA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
 0.87A 5flcF-4qdrA:
undetectable		 5flcF-4qdrA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 9 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
 1.17A 6bklE-4qdrA:
undetectable
6bklF-4qdrA:
undetectable
6bklG-4qdrA:
undetectable
6bklH-4qdrA:
undetectable		 6bklE-4qdrA:
6.31
6bklF-4qdrA:
6.31
6bklG-4qdrA:
6.31
6bklH-4qdrA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 12 ARG A 408
ILE A 418
LEU A 420
GLY A 317
ALA A 295
 None
 1.05A 6c2mA-4qdrA:
undetectable		 6c2mA-4qdrA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4qdr NEUROPILIN-2
(Homo
sapiens) 		5 / 10 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.89A 6f5uA-4qdrA:
undetectable
6f5uB-4qdrA:
undetectable		 6f5uA-4qdrA:
15.60
6f5uB-4qdrA:
13.14