SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4qds NEUROPILIN-2
(Homo
sapiens) 		3 / 3 ARG A 405
GLY A 369
SER A 294
 None
 0.64A 2xctB-4qdsA:
undetectable		 2xctB-4qdsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4qds NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
 0.99A 5flcB-4qdsA:
undetectable		 5flcB-4qdsA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4qds NEUROPILIN-2
(Homo
sapiens) 		4 / 8 GLY A 346
THR A 305
TRP A 318
TYR A 299
 None
 0.98A 5flcF-4qdsA:
undetectable		 5flcF-4qdsA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4qds NEUROPILIN-2
(Homo
sapiens) 		5 / 10 VAL A 407
LEU A 339
LEU A 398
LEU A 422
LEU A 424
 None
 0.89A 6f5uA-4qdsA:
undetectable
6f5uB-4qdsA:
undetectable		 6f5uA-4qdsA:
18.42
6f5uB-4qdsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4qds NEUROPILIN-2
(Homo
sapiens) 		4 / 7 VAL A 407
LEU A 339
LEU A 398
LEU A 422
 None
 0.71A 6g9bA-4qdsA:
undetectable
6g9bB-4qdsA:
undetectable		 6g9bA-4qdsA:
18.42
6g9bB-4qdsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4qds NEUROPILIN-2
(Homo
sapiens) 		4 / 6 THR A 337
LEU A 336
MET A 440
THR A 340
 None
 1.04A 6mvxA-4qdsA:
undetectable
6mvxB-4qdsA:
undetectable
6mvxC-4qdsA:
undetectable		 6mvxA-4qdsA:
19.40
6mvxB-4qdsA:
19.40
6mvxC-4qdsA:
19.40