SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qdv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		4 / 8 LEU A 202
ALA A 220
VAL A 278
VAL A 265
 None
 0.87A 1epbB-4qdvA:
undetectable		 1epbB-4qdvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		5 / 11 GLY A 289
PRO A 288
TYR A 217
HIS A 279
HIS A 268
 None
None
None
PO4  A 402 (-4.0A)
PO4  A 402 ( 3.8A)
 1.46A 1tmxA-4qdvA:
undetectable		 1tmxA-4qdvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 244
TYR A 312
LEU A 230
CYH A 222
LEU A 267
 None
PO4  A 403 (-4.5A)
None
None
None
 1.20A 2bxfA-4qdvA:
undetectable		 2bxfA-4qdvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		5 / 9 GLY A 248
ASN A 243
ILE A 244
ALA A 220
VAL A 278
 None
 1.39A 2drdA-4qdvA:
undetectable		 2drdA-4qdvA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 219
GLU A 185
SER A 172
ILE A 173
ARG A 225
 30U  A 401 (-4.4A)
30U  A 401 (-2.3A)
None
None
None
 1.31A 3ia4B-4qdvA:
undetectable		 3ia4B-4qdvA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		4 / 5 GLN A 249
ILE A 302
LEU A 245
PHE A 280
 None
 1.25A 3ls4L-4qdvA:
undetectable		 3ls4L-4qdvA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 277
HIS A 279
ILE A 219
 PO4  A 402 (-3.7A)
PO4  A 402 (-4.0A)
30U  A 401 (-4.4A)
 0.85A 3u52A-4qdvA:
undetectable
3u52C-4qdvA:
undetectable		 3u52A-4qdvA:
23.05
3u52C-4qdvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		4 / 5 PHE A 319
TYR A 269
THR A 154
ILE A 151
 None
 1.23A 4jx1E-4qdvA:
undetectable		 4jx1E-4qdvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		4 / 8 LEU A 230
LEU A 298
HIS A 311
LEU A 305
 None
None
PO4  A 403 (-4.0A)
None
 1.10A 5dxeA-4qdvA:
undetectable		 5dxeA-4qdvA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		4 / 6 VAL A 278
LEU A 298
CYH A 222
LEU A 240
 None
 0.96A 5hrqB-4qdvA:
undetectable
5hrqI-4qdvA:
undetectable
5hrqJ-4qdvA:
undetectable		 5hrqB-4qdvA:
9.24
5hrqI-4qdvA:
7.00
5hrqJ-4qdvA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 179
ASP A 205
SER A 272
HIS A 277
HIS A 279
 None
30U  A 401 (-2.4A)
PO4  A 404 ( 2.7A)
PO4  A 402 (-3.7A)
PO4  A 402 (-4.0A)
 0.76A 5km9B-4qdvA:
11.4		 5km9B-4qdvA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		6 / 12 VAL A 176
ILE A 179
ILE A 203
ASP A 205
HIS A 277
HIS A 279
 None
None
30U  A 401 ( 4.0A)
30U  A 401 (-2.4A)
PO4  A 402 (-3.7A)
PO4  A 402 (-4.0A)
 1.26A 5uvmB-4qdvA:
10.6		 5uvmB-4qdvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens) 		4 / 8 LEU A 230
LEU A 298
HIS A 311
LEU A 305
 None
None
PO4  A 403 (-4.0A)
None
 1.10A 6cbzA-4qdvA:
undetectable		 6cbzA-4qdvA:
14.63