SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qed'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		3 / 3 PHE A 147
LEU A 247
SER A 140
 None
None
NAP  A 300 ( 3.9A)
 0.69A 1e7aA-4qedA:
undetectable		 1e7aA-4qedA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 11 CYH A 119
LEU A  84
THR A   9
ILE A  70
VAL A  67
 None
 1.24A 1pkvA-4qedA:
undetectable
1pkvB-4qedA:
undetectable		 1pkvA-4qedA:
18.57
1pkvB-4qedA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 11 ILE A  70
VAL A  67
CYH A 119
LEU A  84
THR A   9
 None
 1.24A 1pkvA-4qedA:
undetectable
1pkvB-4qedA:
undetectable		 1pkvA-4qedA:
18.57
1pkvB-4qedA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 12 GLY A 143
GLY A 154
ILE A 141
ASP A 243
SER A 139
 None
 1.20A 1ri4A-4qedA:
5.3		 1ri4A-4qedA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		4 / 6 SER A 139
VAL A 160
GLY A 154
GLY A 143
 None
 0.76A 1tnlA-4qedA:
undetectable		 1tnlA-4qedA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 11 ILE A  15
VAL A  19
ALA A  20
PHE A  23
ILE A  32
 NAP  A 300 (-3.7A)
None
None
None
None
 0.63A 1uduA-4qedA:
undetectable		 1uduA-4qedA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 12 LEU A 247
ASP A 219
VAL A 220
ILE A 186
SER A  93
 None
None
None
NAP  A 300 (-4.2A)
None
 1.18A 1zq9A-4qedA:
6.0		 1zq9A-4qedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		4 / 6 SER A 139
VAL A 160
GLY A 154
GLY A 143
 None
 0.78A 2otvA-4qedA:
undetectable		 2otvA-4qedA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4qed ELXO
(Staphylococcus
epidermidis) 		4 / 7 TYR A  57
ASN A   5
LEU A  24
PHE A  78
 None
 0.98A 3nk2X-4qedA:
3.4		 3nk2X-4qedA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		4 / 6 SER A 139
VAL A 160
GLY A 154
GLY A 143
 None
 0.72A 3rxfA-4qedA:
undetectable		 3rxfA-4qedA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 12 GLY A 154
SER A 140
ILE A 113
SER A 150
PHE A 105
 None
NAP  A 300 ( 3.9A)
None
None
None
 1.28A 4obwC-4qedA:
6.3		 4obwC-4qedA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 12 GLY A 184
GLY A 215
ILE A 208
SER A 206
ILE A 242
 None
 1.10A 4qtuB-4qedA:
5.5		 4qtuB-4qedA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 12 GLY A 184
GLY A 215
ILE A 208
SER A 206
ILE A 242
 None
 1.02A 4qtuD-4qedA:
6.4		 4qtuD-4qedA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 12 GLY A  11
SER A  34
ASP A  60
VAL A  61
THR A  62
 None
NAP  A 300 (-2.6A)
NAP  A 300 (-3.3A)
NAP  A 300 (-3.5A)
NAP  A 300 ( 4.1A)
 1.12A 5kpcB-4qedA:
5.3		 5kpcB-4qedA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4qed ELXO
(Staphylococcus
epidermidis) 		4 / 8 VAL A  30
ILE A   8
THR A  33
TYR A  57
 None
 1.07A 6cduG-4qedA:
undetectable
6cduH-4qedA:
undetectable		 6cduG-4qedA:
21.53
6cduH-4qedA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 10 PHE A 147
SER A 140
GLY A 143
ILE A 141
ILE A 185
 None
NAP  A 300 ( 3.9A)
None
None
None
 1.13A 6ebpD-4qedA:
undetectable		 6ebpD-4qedA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4qed ELXO
(Staphylococcus
epidermidis) 		5 / 11 PHE A 147
SER A 140
GLY A 143
ILE A 141
ILE A 185
 None
NAP  A 300 ( 3.9A)
None
None
None
 1.08A 6gp2B-4qedA:
undetectable		 6gp2B-4qedA:
14.51