SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 5 PHE A  79
GLY A 611
THR A 538
PHE A 553
 None
 1.10A 1icuC-4qeiA:
1.2
1icuD-4qeiA:
1.9		 1icuC-4qeiA:
17.02
1icuD-4qeiA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 11 ILE A 347
LEU A 352
ASP A 302
PHE A 355
VAL A 351
 None
 1.12A 2fxdA-4qeiA:
undetectable		 2fxdA-4qeiA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 6 THR A  73
ARG A  76
ASP A 608
ASP A 634
 None
A  C  37 ( 4.5A)
None
None
 1.25A 2okcA-4qeiA:
undetectable		 2okcA-4qeiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 6 THR A  73
ARG A  76
ASP A 608
ASP A 634
 None
A  C  37 ( 4.5A)
None
None
 1.26A 2okcB-4qeiA:
undetectable		 2okcB-4qeiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 6 ALA A 605
ASP A 608
GLU A 609
ARG A  76
 A  C  37 ( 3.6A)
None
A  C  37 ( 3.4A)
A  C  37 ( 4.5A)
 1.25A 2ouzA-4qeiA:
undetectable		 2ouzA-4qeiA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 GLY A 100
GLY A  71
PHE A 551
PHE A 553
 None
 0.95A 2qwxA-4qeiA:
3.8
2qwxB-4qeiA:
3.9		 2qwxA-4qeiA:
16.83
2qwxB-4qeiA:
16.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		6 / 7 GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
 None
AMP  A 701 (-2.9A)
None
None
None
AMP  A 701 (-3.2A)
 0.54A 2zt7A-4qeiA:
42.4		 2zt7A-4qeiA:
99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 5 ILE A 107
THR A 538
PHE A 551
PHE A  79
 None
 1.17A 3em0A-4qeiA:
undetectable		 3em0A-4qeiA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 LYS A 143
ILE A 250
PHE A 254
 None
 0.98A 3j7zS-4qeiA:
2.0
3j7za-4qeiA:
undetectable		 3j7zS-4qeiA:
10.05
3j7za-4qeiA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 GLU A 343
LEU A 352
LYS A 389
ASN A 349
 None
 1.43A 3k8mA-4qeiA:
undetectable		 3k8mA-4qeiA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		6 / 6 GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
 None
AMP  A 701 (-2.9A)
None
None
None
AMP  A 701 (-3.2A)
 0.71A 4kr3A-4qeiA:
52.5		 4kr3A-4qeiA:
99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 6 LEU A 252
LEU A 135
PHE A 292
MET A 294
 None
None
AMP  A 701 (-3.6A)
AMP  A 701 (-3.2A)
 1.06A 4o1zA-4qeiA:
undetectable		 4o1zA-4qeiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PHE A 144
PRO A 244
ARG A 277
GLY A 406
 None
None
None
AMP  A 701 (-2.9A)
AMP  A 701 (-4.0A)
 1.10A 4q15A-4qeiA:
24.7		 4q15A-4qeiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PRO A 244
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 1.01A 4q15B-4qeiA:
24.7		 4q15B-4qeiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PHE A 144
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 1.20A 4ydqA-4qeiA:
23.7		 4ydqA-4qeiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PRO A 244
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 0.99A 4ydqA-4qeiA:
23.7		 4ydqA-4qeiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PRO A 244
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 0.93A 5f9zA-4qeiA:
23.3		 5f9zA-4qeiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PRO A 244
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 0.90A 5f9zB-4qeiA:
23.6		 5f9zB-4qeiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 4 THR A 364
LEU A 361
HIS A 114
GLY A 357
 None
 1.50A 5gwyA-4qeiA:
0.0		 5gwyA-4qeiA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 THR A 607
SER A 563
ASP A 634
 None
 0.83A 5kvaA-4qeiA:
undetectable		 5kvaA-4qeiA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 LYS A 143
LYS A 136
SER A 138
 None
 1.47A 5odiA-4qeiA:
3.0		 5odiA-4qeiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PHE A 144
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 1.22A 5xiqD-4qeiA:
23.9		 5xiqD-4qeiA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 135
PRO A 244
ARG A 277
GLU A 296
GLY A 406
 None
None
AMP  A 701 (-2.9A)
None
AMP  A 701 (-4.0A)
 1.00A 5xiqD-4qeiA:
23.9		 5xiqD-4qeiA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 10 ARG A 277
GLU A 279
PHE A 292
GLY A 526
ARG A 529
 AMP  A 701 (-2.9A)
AMP  A 701 (-4.3A)
AMP  A 701 (-3.6A)
AMP  A 701 (-3.2A)
AMP  A 701 (-4.1A)
 0.64A 6bniA-4qeiA:
11.8		 6bniA-4qeiA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 10 ARG A 277
GLU A 279
PHE A 292
GLY A 526
ARG A 529
 AMP  A 701 (-2.9A)
AMP  A 701 (-4.3A)
AMP  A 701 (-3.6A)
AMP  A 701 (-3.2A)
AMP  A 701 (-4.1A)
 0.58A 6bniB-4qeiA:
13.7		 6bniB-4qeiA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 415
ILE A 250
ALA A 428
CYH A 126
LEU A 265
 None
 1.32A 6ie8A-4qeiA:
undetectable		 6ie8A-4qeiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4qei GLYCINE--TRNA LIGASE
(Homo
sapiens) 		4 / 8 ASP A  66
HIS A 537
ARG A  67
GLU A 536
 None
None
C  C  70 ( 4.5A)
None
 1.24A 6mn4B-4qeiA:
undetectable		 6mn4B-4qeiA:
18.49