SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qeo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		4 / 7 PHE A 549
GLU A 492
TYR A 493
LYS A 456
 None
SAH  A 801 ( 3.2A)
SAH  A 801 (-4.0A)
SAH  A 801 (-4.7A)
 1.08A 1rmtB-4qeoA:
undetectable		 1rmtB-4qeoA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		3 / 3 LYS A 123
ASP A 391
CYH A 385
 None
None
ZN  A 804 (-2.4A)
 1.47A 2br4F-4qeoA:
undetectable		 2br4F-4qeoA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.37A 2r3aA-4qeoA:
27.6		 2r3aA-4qeoA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TYR A 493
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.75A 2r3aA-4qeoA:
27.6		 2r3aA-4qeoA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		4 / 6 PRO A 585
SER A 584
TYR A 465
CYH A 264
 None
 0.71A 2x7hA-4qeoA:
undetectable		 2x7hA-4qeoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.72A 3ooiA-4qeoA:
18.1		 3ooiA-4qeoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.54A 3ooiA-4qeoA:
18.1		 3ooiA-4qeoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 LYS A 456
GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.53A 3opeA-4qeoA:
17.1		 3opeA-4qeoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 9 GLY A 457
TRP A 458
TYR A 493
ASN A 551
TYR A 593
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
 0.45A 3opeB-4qeoA:
16.6		 3opeB-4qeoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 9 LYS A 456
GLY A 457
TRP A 458
TYR A 493
ASN A 551
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
 0.91A 3opeB-4qeoA:
16.6		 3opeB-4qeoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.91A 3qxyA-4qeoA:
5.8		 3qxyA-4qeoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.88A 3rc0B-4qeoA:
5.7		 3rc0B-4qeoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.40A 3rq4A-4qeoA:
2.2		 3rq4A-4qeoA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.45A 3s8pA-4qeoA:
8.1		 3s8pA-4qeoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		4 / 6 GLY A 261
VAL A 202
SER A 204
THR A 259
 None
 0.87A 3tj7A-4qeoA:
undetectable
3tj7B-4qeoA:
undetectable		 3tj7A-4qeoA:
17.72
3tj7B-4qeoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		4 / 6 GLY A 261
VAL A 202
SER A 204
THR A 259
 None
 0.87A 3tj7C-4qeoA:
undetectable
3tj7D-4qeoA:
undetectable		 3tj7C-4qeoA:
17.72
3tj7D-4qeoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		4 / 6 VAL A 202
SER A 204
THR A 259
GLY A 261
 None
 0.89A 3tj7C-4qeoA:
undetectable
3tj7D-4qeoA:
undetectable		 3tj7C-4qeoA:
17.72
3tj7D-4qeoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.45A 4bupA-4qeoA:
8.0		 4bupA-4qeoA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 10 LYS A 456
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-4.7A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.71A 4ij8A-4qeoA:
11.2
4ij8B-4qeoA:
10.9		 4ij8A-4qeoA:
15.38
4ij8B-4qeoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_B_SAMB501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 9 LYS A 456
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-4.7A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.73A 4ij8A-4qeoA:
11.2
4ij8B-4qeoA:
10.9		 4ij8A-4qeoA:
15.38
4ij8B-4qeoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 ILE A 370
LEU A 368
VAL A 563
ALA A 573
LEU A 572
 None
 1.39A 4m11C-4qeoA:
undetectable		 4m11C-4qeoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.54A 4ynmA-4qeoA:
17.1		 4ynmA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.56A 4ynmB-4qeoA:
17.0		 4ynmB-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.51A 4ynpA-4qeoA:
17.2		 4ynpA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TYR A 493
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.46A 4ynpA-4qeoA:
17.2		 4ynpA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 10 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.45A 4ynpB-4qeoA:
16.8		 4ynpB-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 10 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 1.45A 4ynpB-4qeoA:
16.8		 4ynpB-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.42A 4ypaA-4qeoA:
17.4		 4ypaA-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.38A 4ypaA-4qeoA:
17.4		 4ypaA-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.37A 4ypaB-4qeoA:
17.9		 4ypaB-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 LYS A 456
GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.41A 4ypaB-4qeoA:
17.9		 4ypaB-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.44A 4ypaC-4qeoA:
17.1		 4ypaC-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 LYS A 456
GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.49A 4ypaC-4qeoA:
17.1		 4ypaC-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 LYS A 456
GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.49A 4ypaD-4qeoA:
17.4		 4ypaD-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 1.42A 4ypaD-4qeoA:
17.4		 4ypaD-4qeoA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.53A 4ypeA-4qeoA:
17.6		 4ypeA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.44A 4ypeA-4qeoA:
17.6		 4ypeA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 11 LYS A 456
GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.55A 4ypeB-4qeoA:
17.4		 4ypeB-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.51A 4ypuA-4qeoA:
17.1		 4ypuA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.42A 4ypuA-4qeoA:
17.1		 4ypuA-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 11 LYS A 456
GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.35A 4ypuB-4qeoA:
16.7		 4ypuB-4qeoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		3 / 3 ASN A 582
ALA A 468
ARG A 414
 None
 0.48A 5cvtB-4qeoA:
undetectable		 5cvtB-4qeoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		3 / 3 ASP A 312
ARG A 350
ARG A 461
 None
 0.94A 5eajB-4qeoA:
undetectable		 5eajB-4qeoA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.49A 5jhnA-4qeoA:
19.6		 5jhnA-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.51A 5jhnB-4qeoA:
29.6		 5jhnB-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 0.55A 5jinA-4qeoA:
29.4		 5jinA-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.55A 5jinB-4qeoA:
29.7		 5jinB-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.52A 5jiyA-4qeoA:
29.3		 5jiyA-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.57A 5jiyB-4qeoA:
29.5		 5jiyB-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 0.57A 5jj0A-4qeoA:
29.3		 5jj0A-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.34A 5jj0B-4qeoA:
29.5		 5jj0B-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.43A 5jj0B-4qeoA:
29.5		 5jj0B-4qeoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		3 / 3 ARG A 419
PRO A 406
ASN A 437
 None
 1.04A 5jwaA-4qeoA:
undetectable
5jwaH-4qeoA:
undetectable		 5jwaA-4qeoA:
21.27
5jwaH-4qeoA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
ASN A 551
HIS A 552
TYR A 593
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-3.2A)
None
None
None
 0.90A 5kklB-4qeoA:
9.4		 5kklB-4qeoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
HIS A 552
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.66A 5lsuA-4qeoA:
18.3		 5lsuA-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
TYR A 493
HIS A 552
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
ZN  A 805 ( 2.4A)
None
 0.71A 5lsuB-4qeoA:
18.2		 5lsuB-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		3 / 3 ASN A 551
TYR A 593
CYH A 612
 SAH  A 801 (-3.2A)
None
ZN  A 805 ( 2.4A)
 0.20A 5lsuB-4qeoA:
18.2		 5lsuB-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.39A 5t0kA-4qeoA:
29.5		 5t0kA-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.39A 5t0kA-4qeoA:
29.5		 5t0kA-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.35A 5t0kA-4qeoA:
29.5		 5t0kA-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.31A 5t0kB-4qeoA:
29.1		 5t0kB-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.36A 5t0kB-4qeoA:
29.1		 5t0kB-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.54A 5t0mA-4qeoA:
29.5		 5t0mA-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.35A 5t0mB-4qeoA:
29.5		 5t0mB-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.51A 5t0mB-4qeoA:
29.5		 5t0mB-4qeoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 9 LYS A 456
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-4.7A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.57A 5tegA-4qeoA:
12.1
5tegD-4qeoA:
undetectable		 5tegA-4qeoA:
16.21
5tegD-4qeoA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 10 LYS A 456
GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.56A 5tegB-4qeoA:
8.9
5tegE-4qeoA:
undetectable		 5tegB-4qeoA:
16.21
5tegE-4qeoA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 10 GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
 0.37A 5tqrB-4qeoA:
11.7		 5tqrB-4qeoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.49A 5ttfA-4qeoA:
29.5		 5ttfA-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.53A 5ttfB-4qeoA:
29.2		 5ttfB-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.54A 5ttfC-4qeoA:
28.9		 5ttfC-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.60A 5ttfD-4qeoA:
19.6		 5ttfD-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.57A 5ttgA-4qeoA:
29.5		 5ttgA-4qeoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.58A 5ttgB-4qeoA:
19.5		 5ttgB-4qeoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.53A 5tuyA-4qeoA:
29.1		 5tuyA-4qeoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.52A 5tuyB-4qeoA:
18.8		 5tuyB-4qeoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.47A 5tuzA-4qeoA:
19.9		 5tuzA-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.45A 5tuzA-4qeoA:
19.9		 5tuzA-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.56A 5tuzB-4qeoA:
19.8		 5tuzB-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		9 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.62A 5updA-4qeoA:
17.7		 5updA-4qeoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 11 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 1.41A 5updA-4qeoA:
17.7		 5updA-4qeoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
LEU A 623
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
None
 0.59A 5v21A-4qeoA:
17.8		 5v21A-4qeoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 LYS A 456
GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.44A 5v21A-4qeoA:
17.8		 5v21A-4qeoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 LYS A 456
GLY A 457
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
LEU A 623
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
None
 0.38A 5v21A-4qeoA:
17.8		 5v21A-4qeoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.53A 5v9iA-4qeoA:
29.3		 5v9iA-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.55A 5v9iB-4qeoA:
29.2		 5v9iB-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.65A 5v9iC-4qeoA:
29.3		 5v9iC-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 0.74A 5v9iD-4qeoA:
29.1		 5v9iD-4qeoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.54A 5v9jA-4qeoA:
29.3		 5v9jA-4qeoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.57A 5v9jB-4qeoA:
29.4		 5v9jB-4qeoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 9 GLY A 242
LEU A 246
ILE A 201
GLY A 178
ILE A 147
 None
 0.96A 5vkqC-4qeoA:
2.1
5vkqD-4qeoA:
2.1		 5vkqC-4qeoA:
15.30
5vkqD-4qeoA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.48A 5vscA-4qeoA:
29.5		 5vscA-4qeoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.48A 5vscB-4qeoA:
29.1		 5vscB-4qeoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 1.49A 5vscB-4qeoA:
29.1		 5vscB-4qeoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.43A 5vsdA-4qeoA:
29.5		 5vsdA-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.44A 5vsdA-4qeoA:
29.5		 5vsdA-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.57A 5vsdB-4qeoA:
29.4		 5vsdB-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.49A 5vseA-4qeoA:
29.5		 5vseA-4qeoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.34A 5vseB-4qeoA:
29.3		 5vseB-4qeoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.50A 5vseB-4qeoA:
29.3		 5vseB-4qeoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.46A 5vsfA-4qeoA:
29.5		 5vsfA-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.47A 5vsfA-4qeoA:
29.5		 5vsfA-4qeoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
 0.55A 5vsfB-4qeoA:
29.4		 5vsfB-4qeoA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		9 / 12 GLY A 457
TRP A 458
GLU A 492
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 ( 3.2A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.49A 6a5kA-4qeoA:
38.4		 6a5kA-4qeoA:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 12 GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
 1.47A 6a5kA-4qeoA:
38.4		 6a5kA-4qeoA:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		9 / 12 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.56A 6a5mA-4qeoA:
37.6		 6a5mA-4qeoA:
40.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.76A 6agoA-4qeoA:
16.9		 6agoA-4qeoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 11 LYS A 456
GLY A 457
TRP A 458
TYR A 493
ASN A 551
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
ZN  A 805 ( 2.4A)
 1.13A 6agoA-4qeoA:
16.9		 6agoA-4qeoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		5 / 11 LYS A 456
GLY A 457
TRP A 458
TYR A 493
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
ZN  A 805 ( 2.4A)
 1.42A 6agoA-4qeoA:
16.9		 6agoA-4qeoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
ARG A 548
HIS A 552
TYR A 593
CYH A 614
LEU A 623
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.8A)
None
None
ZN  A 805 ( 2.4A)
None
 0.72A 6bp4A-4qeoA:
27.2		 6bp4A-4qeoA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		7 / 12 LYS A 456
GLY A 457
TRP A 458
HIS A 552
TYR A 593
CYH A 614
LEU A 623
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
None
None
ZN  A 805 ( 2.4A)
None
 0.56A 6bp4A-4qeoA:
27.2		 6bp4A-4qeoA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		9 / 12 LYS A 456
GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.66A 6bp4B-4qeoA:
27.0		 6bp4B-4qeoA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		9 / 11 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.61A 6cenA-4qeoA:
18.5		 6cenA-4qeoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 11 GLY A 457
TRP A 458
TYR A 493
HIS A 552
TYR A 593
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
None
ZN  A 805 ( 2.4A)
 1.45A 6cenA-4qeoA:
18.5		 6cenA-4qeoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		6 / 12 TRP A 458
TYR A 493
PHE A 549
ASN A 551
HIS A 552
LEU A 623
 SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
SAH  A 801 (-3.2A)
None
None
 0.75A 6chgC-4qeoA:
13.2		 6chgC-4qeoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4
(Arabidopsis
thaliana) 		8 / 12 LYS A 456
GLY A 457
TRP A 458
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-4.7A)
SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.30A 6ineA-4qeoA:
16.7		 6ineA-4qeoA:
21.92