SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 116
PRO H 146
THR H 115
PRO H 117
 None
 1.30A 1dsdC-4qexH:
undetectable		 1dsdC-4qexH:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 116
PRO H 146
THR H 115
PRO H 117
 None
 1.30A 1dsdC-4qexH:
undetectable		 1dsdC-4qexH:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 8 ASN H  52
ILE H  51
GLY H  50
GLY H  95
 None
 0.78A 1me7A-4qexH:
undetectable		 1me7A-4qexH:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		4 / 8 SER A  68
LEU A  96
ASP A  97
GLU A 173
 None
 1.20A 1mxgA-4qexA:
undetectable		 1mxgA-4qexA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		4 / 6 LEU A  91
GLU A 153
ILE A 169
PRO A 170
 None
 1.03A 2fcnA-4qexA:
undetectable
2fcnB-4qexA:
undetectable		 2fcnA-4qexA:
7.86
2fcnB-4qexA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		4 / 5 TYR A 277
GLU A 370
ARG A 223
ASP A 312
 None
 1.46A 2yqzA-4qexA:
undetectable		 2yqzA-4qexA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		4 / 5 TYR A 277
GLU A 370
ARG A 223
ASP A 312
 None
 1.43A 2yqzB-4qexA:
undetectable		 2yqzB-4qexA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		5 / 9 ARG A 348
LEU A 383
VAL A 323
ILE A 375
ILE A 382
 None
 1.07A 3ekqB-4qexA:
undetectable		 3ekqB-4qexA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 160
SER H 159
HIS H 163
 None
 0.82A 3mzeA-4qexH:
undetectable		 3mzeA-4qexH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		3 / 3 TYR H  96
TYR H 101
GLU H  31
 None
 0.94A 3pfgA-4qexH:
undetectable		 3pfgA-4qexH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 4 ASN H 195
SER H 160
LEU H 158
THR H 150
 None
 1.35A 4an2A-4qexH:
undetectable		 4an2A-4qexH:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 202
ALA H 197
VAL H 196
 None
 0.60A 4x1iA-4qexH:
undetectable		 4x1iA-4qexH:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		4 / 7 HIS A 371
GLY A 317
ASN A 356
HIS A 285
 None
 1.11A 5a5zC-4qexA:
undetectable		 5a5zC-4qexA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 202
ALA H 197
VAL H 196
 None
 0.57A 5eypA-4qexH:
undetectable		 5eypA-4qexH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4qex ERYTHROCYTE-BINDING
ANTIGEN-175
(Plasmodium
falciparum) 		3 / 3 TRP A 463
ILE A 377
SER A 380
 None
 0.84A 5gqbA-4qexA:
undetectable		 5gqbA-4qexA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		4 / 4 VAL H 120
LEU H 123
ASN H 195
ASP H 206
 None
 1.34A 5vcyA-4qexH:
undetectable		 5vcyA-4qexH:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4qex ANTIBODY HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER H 202
ALA H 197
VAL H 196
 None
 0.51A 5xiwC-4qexH:
undetectable		 5xiwC-4qexH:
16.06