SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 TRP L  35
TYR L  34
LEU L  28
 None
 1.07A 1kxhA-4qf1L:
undetectable		 1kxhA-4qf1L:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		5 / 12 ASP L  85
LYS L 103
PRO L   7
GLY L  99
LEU L   4
 None
 1.39A 2nv4B-4qf1L:
undetectable		 2nv4B-4qf1L:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		5 / 7 TYR L  32
TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.81A 5aclA-4qf1L:
20.4		 5aclA-4qf1L:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 THR L  91
SER L  90
TYR L  89
 None
 0.82A 5jsdA-4qf1L:
2.5		 5jsdA-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 THR L  91
SER L  90
TYR L  89
 None
 0.82A 5jsdB-4qf1L:
undetectable		 5jsdB-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 THR L  91
SER L  90
TYR L  89
 None
 0.81A 5jsdC-4qf1L:
undetectable		 5jsdC-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 THR L  91
SER L  90
TYR L  89
 None
 0.84A 5jseA-4qf1L:
2.2		 5jseA-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 THR L  91
SER L  90
TYR L  89
 None
 0.83A 5jseB-4qf1L:
2.6		 5jseB-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		3 / 3 THR L  91
SER L  90
TYR L  89
 None
 0.83A 5jseC-4qf1L:
undetectable		 5jseC-4qf1L:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		4 / 8 THR L  74
SER L  63
THR L  72
SER L  65
 None
 1.00A 5l4eA-4qf1L:
undetectable
5l4eB-4qf1L:
undetectable
5l4eC-4qf1L:
undetectable
5l4eD-4qf1L:
undetectable
5l4eE-4qf1L:
undetectable		 5l4eA-4qf1L:
21.40
5l4eB-4qf1L:
21.40
5l4eC-4qf1L:
21.40
5l4eD-4qf1L:
21.40
5l4eE-4qf1L:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.00A 5l4iA-4qf1L:
undetectable		 5l4iA-4qf1L:
24.20