SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.10A 1l5qA-4qfeA:
undetectable		 1l5qA-4qfeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.13A 1l5qB-4qfeA:
undetectable		 1l5qB-4qfeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.12A 1l7xA-4qfeA:
undetectable		 1l7xA-4qfeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.07A 1l7xB-4qfeA:
undetectable		 1l7xB-4qfeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 113
MET A  85
LEU A 137
CYH A  61
THR A  59
 None
 1.49A 1ya3A-4qfeA:
undetectable		 1ya3A-4qfeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.16A 2ejfB-4qfeA:
undetectable		 2ejfB-4qfeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.20A 2ejgA-4qfeA:
undetectable		 2ejgA-4qfeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.20A 2ejgB-4qfeA:
undetectable		 2ejgB-4qfeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 113
MET A  85
LEU A 137
CYH A  61
THR A  59
 None
 1.46A 2oaxA-4qfeA:
undetectable		 2oaxA-4qfeA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 113
MET A  85
LEU A 137
CYH A  61
THR A  59
 None
 1.47A 2oaxF-4qfeA:
undetectable		 2oaxF-4qfeA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A  51
THR A  14
ALA A  48
ARG A   9
 None
 0.90A 2ql8A-4qfeA:
undetectable
2ql8B-4qfeA:
undetectable		 2ql8A-4qfeA:
19.69
2ql8B-4qfeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 111
GLY A 107
VAL A  16
ALA A  64
PRO A  87
 None
 1.24A 2vmyB-4qfeA:
undetectable		 2vmyB-4qfeA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.16A 2zgwB-4qfeA:
undetectable		 2zgwB-4qfeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.14A 3bcrA-4qfeA:
undetectable		 3bcrA-4qfeA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  53
VAL A  16
LEU A  92
ASP A  45
 None
None
EDO  A 303 (-4.0A)
None
 0.81A 3cs9D-4qfeA:
undetectable		 3cs9D-4qfeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.09A 3dd1A-4qfeA:
undetectable		 3dd1A-4qfeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.13A 3dd1B-4qfeA:
undetectable		 3dd1B-4qfeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.12A 3ddsA-4qfeA:
undetectable		 3ddsA-4qfeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.11A 3ddsB-4qfeA:
undetectable		 3ddsB-4qfeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.12A 3ddwA-4qfeA:
undetectable		 3ddwA-4qfeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 176
ALA A 175
GLY A 173
TYR A 170
 None
 1.11A 3ddwB-4qfeA:
undetectable		 3ddwB-4qfeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 113
ARG A 118
ILE A 172
ARG A 153
 None
 1.41A 3ticA-4qfeA:
undetectable		 3ticA-4qfeA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 PRO A  87
LEU A  35
ILE A  18
ARG A  20
 None
 1.40A 3w1wA-4qfeA:
undetectable		 3w1wA-4qfeA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  39
ALA A  51
ILE A   7
GLY A  55
LEU A 111
 None
 0.99A 5m24A-4qfeA:
undetectable		 5m24A-4qfeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TRP A 114
PHE A  39
ALA A  51
ILE A   7
GLY A  55
 EDO  A 303 (-3.6A)
None
None
None
None
 1.08A 5m24A-4qfeA:
undetectable		 5m24A-4qfeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_B_ACTB505_0
(ADENOSYLHOMOCYSTEINA
SE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A  19
ILE A  17
ARG A 185
ARG A   6
 None
 0.99A 5m67B-4qfeA:
1.5		 5m67B-4qfeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 111
GLY A 107
LYS A 136
GLU A 110
LEU A 145
 None
 1.34A 5nwvA-4qfeA:
undetectable		 5nwvA-4qfeA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4qfe ENOYL-COA HYDRATASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLY A  81
GLY A  83
PRO A  84
GLY A  86
 None
 0.77A 6ag0C-4qfeA:
undetectable		 6ag0C-4qfeA:
14.92