SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 350
GLY A 353
VAL A 338
ALA A 542
SER A 329
 None
 1.13A 1eqbA-4qfhA:
undetectable		 1eqbA-4qfhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 350
GLY A 353
VAL A 338
ALA A 542
SER A 329
 None
 1.14A 1eqbB-4qfhA:
undetectable		 1eqbB-4qfhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 350
GLY A 353
VAL A 338
ALA A 542
SER A 329
 None
 1.13A 1eqbC-4qfhA:
undetectable		 1eqbC-4qfhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 350
GLY A 353
VAL A 338
ALA A 542
SER A 329
 None
 1.14A 1eqbD-4qfhA:
undetectable		 1eqbD-4qfhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		6 / 12 SER A 337
VAL A 338
GLY A 335
LEU A 330
TYR A 405
LEU A 402
 None
 1.40A 1fduA-4qfhA:
undetectable		 1fduA-4qfhA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		6 / 12 ILE A 356
ALA A 542
ALA A 354
LEU A 350
LEU A  92
ALA A 539
 None
 1.45A 1fm9A-4qfhA:
undetectable		 1fm9A-4qfhA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 7 PHE A 347
SER A 182
SER A 341
ILE A 342
 None
 1.06A 1fxhA-4qfhA:
undetectable
1fxhB-4qfhA:
undetectable		 1fxhA-4qfhA:
17.23
1fxhB-4qfhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		6 / 12 ILE A 356
ALA A 542
ALA A 354
LEU A 350
LEU A  92
ALA A 539
 None
 1.46A 1k74A-4qfhA:
undetectable		 1k74A-4qfhA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 ALA A 375
VAL A 377
TRP A 380
 None
 0.87A 1tkqB-4qfhA:
undetectable		 1tkqB-4qfhA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 10 GLU A 123
LEU A 120
ILE A  66
GLU A  62
LEU A  60
 None
 1.25A 1wopA-4qfhA:
undetectable		 1wopA-4qfhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.33A 2dcfA-4qfhA:
undetectable		 2dcfA-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 VAL A 147
ASN A 561
TRP A 566
 None
 0.74A 2y00B-4qfhA:
undetectable		 2y00B-4qfhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 10 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.33A 2zm7A-4qfhA:
undetectable		 2zm7A-4qfhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 11 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.36A 2zmaA-4qfhA:
undetectable		 2zmaA-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.29A 3a65A-4qfhA:
undetectable		 3a65A-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 10 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.30A 3a66A-4qfhA:
undetectable		 3a66A-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 MET A 230
ILE A 340
PHE A 232
LEU A 399
GLU A 548
 None
 1.43A 3aocC-4qfhA:
undetectable		 3aocC-4qfhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 4 ILE A 334
GLN A 319
ILE A 256
LEU A 170
 None
 1.17A 3dzyD-4qfhA:
1.3		 3dzyD-4qfhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 THR A 419
ALA A 418
ALA A 556
GLY A 555
ASP A 564
 None
 0.89A 3mg0Y-4qfhA:
undetectable
3mg0Z-4qfhA:
undetectable		 3mg0Y-4qfhA:
16.39
3mg0Z-4qfhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		6 / 12 LEU A 535
LEU A 350
ILE A 543
GLY A 541
ALA A 542
LEU A  92
 None
 1.32A 3n8zB-4qfhA:
0.6		 3n8zB-4qfhA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 10 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.32A 3vwpA-4qfhA:
undetectable		 3vwpA-4qfhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.30A 3vwqA-4qfhA:
undetectable		 3vwqA-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 11 MET A 489
ASP A 103
TYR A 381
GLY A 524
ILE A  72
 None
 1.34A 3vwrA-4qfhA:
undetectable		 3vwrA-4qfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 5 GLU A 436
GLY A 441
TYR A 395
GLN A 484
 None
 1.39A 3w9tG-4qfhA:
undetectable		 3w9tG-4qfhA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 399
LEU A 406
GLN A 390
ILE A 543
TYR A 547
 None
 1.40A 4a79A-4qfhA:
undetectable		 4a79A-4qfhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 399
LEU A 406
GLN A 390
ILE A 543
TYR A 547
 None
 1.38A 4a79B-4qfhA:
undetectable		 4a79B-4qfhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 370
VAL A 100
ASP A 459
ILE A 461
 None
 0.90A 4l4cB-4qfhA:
undetectable		 4l4cB-4qfhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 6 LEU A  88
MET A 357
MET A 546
LEU A 530
 None
 1.15A 4okxA-4qfhA:
undetectable		 4okxA-4qfhA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 207
PHE A 232
GLY A 205
ILE A 256
PRO A 213
 G6P  A 700 ( 4.3A)
None
None
None
None
 1.05A 4rtmA-4qfhA:
3.2		 4rtmA-4qfhA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 TRP A 190
GLY A 192
PHE A 297
ILE A 312
ASN A 316
 None
 1.20A 4rtsA-4qfhA:
undetectable		 4rtsA-4qfhA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 181
GLU A 183
ILE A 340
MET A 339
 None
 0.96A 4ww7A-4qfhA:
undetectable		 4ww7A-4qfhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		3 / 3 GLY A 325
GLY A 326
GLN A 565
 None
G6P  A 700 ( 4.0A)
G6P  A 700 ( 4.7A)
 0.39A 5imsA-4qfhA:
4.5		 5imsA-4qfhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 535
GLY A 212
ALA A 219
LEU A 399
GLY A 335
 None
 1.00A 5kb5A-4qfhA:
undetectable		 5kb5A-4qfhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 555
ILE A 557
THR A 427
VAL A 425
LEU A 376
 None
 1.06A 5nz0A-4qfhA:
undetectable		 5nz0A-4qfhA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 338
GLY A 335
SER A 329
ALA A 216
ASN A 203
 None
 1.24A 5x6yA-4qfhA:
2.8		 5x6yA-4qfhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 353
ALA A 545
HIS A 549
PRO A 537
THR A 352
 None
 1.07A 5x6yC-4qfhA:
undetectable		 5x6yC-4qfhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		6 / 12 ILE A 356
ALA A 542
ALA A 354
LEU A 350
LEU A  92
ALA A 539
 None
 1.39A 5z12B-4qfhA:
undetectable		 5z12B-4qfhA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE
(Trypanosoma
cruzi) 		4 / 6 SER A 209
ALA A 333
SER A 332
ALA A 258
 G6P  A 700 (-2.7A)
None
None
None
 0.79A 6bocA-4qfhA:
undetectable
6bocB-4qfhA:
undetectable
6bocC-4qfhA:
undetectable
6bocD-4qfhA:
undetectable		 6bocA-4qfhA:
3.55
6bocB-4qfhA:
3.55
6bocC-4qfhA:
3.55
6bocD-4qfhA:
3.55