SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 PHE A 418
GLY A 403
PHE A 363
VAL A 344
ALA A 325
 None
 1.41A 1e3vA-4qg5A:
undetectable		 1e3vA-4qg5A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 ILE A 407
VAL A 200
ILE A 307
ILE A 233
VAL A 296
 None
 0.72A 1oipA-4qg5A:
undetectable		 1oipA-4qg5A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 LEU A  88
HIS A 170
ILE A 169
 None
 0.49A 1s9pB-4qg5A:
undetectable		 1s9pB-4qg5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 5 MET A 197
ALA A 194
TYR A 229
ILE A 233
 None
 1.10A 1upfA-4qg5A:
undetectable		 1upfA-4qg5A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 ASP A 260
GLU A 458
ARG A 523
 None
 0.81A 1wopA-4qg5A:
0.7		 1wopA-4qg5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 PHE A  39
ASN A 133
THR A  38
GLY A  87
LEU A  89
 None
 1.06A 2hw2A-4qg5A:
undetectable		 2hw2A-4qg5A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 10 ASP A 301
ILE A 233
THR A  91
ILE A 206
GLY A 403
 MG  A 601 (-2.4A)
None
None
None
None
 1.37A 2v0mA-4qg5A:
undetectable		 2v0mA-4qg5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 PHE A 313
ASN A 280
PHE A 312
 None
 0.91A 2zbuD-4qg5A:
undetectable		 2zbuD-4qg5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 TYR A 265
ASP A 260
HIS A 223
 None
 0.94A 3e23A-4qg5A:
undetectable		 3e23A-4qg5A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		6 / 12 TRP A 419
LEU A 417
LEU A 238
GLN A 211
LEU A 245
VAL A 296
 None
 1.44A 3ix9A-4qg5A:
undetectable		 3ix9A-4qg5A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 ASP A 301
SER A 118
ARG A 304
 MG  A 601 (-2.4A)
MG  A 601 (-1.9A)
MG  A 601 ( 4.7A)
 0.73A 3loqA-4qg5A:
undetectable		 3loqA-4qg5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 TYR A 229
ASP A 411
ASP A 299
 None
None
MG  A 601 (-2.9A)
 0.88A 3ou7B-4qg5A:
undetectable		 3ou7B-4qg5A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 10 PHE A 113
ASN A 133
ALA A 140
ILE A 148
PHE A  34
 None
 1.48A 3t3qB-4qg5A:
undetectable		 3t3qB-4qg5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 10 PHE A 113
ASN A 133
ALA A 140
ILE A 148
PHE A  34
 None
 1.49A 3t3qC-4qg5A:
undetectable		 3t3qC-4qg5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 5 LEU A 394
GLY A 403
MET A 379
PHE A 332
 None
 1.24A 3uq6B-4qg5A:
undetectable		 3uq6B-4qg5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 11 HIS A 406
SER A 404
ASP A 328
PHE A 333
VAL A 422
 None
 1.22A 4fogC-4qg5A:
undetectable		 4fogC-4qg5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 ASP A 303
ARG A 304
ASP A  57
 MG  A 601 (-1.7A)
MG  A 601 ( 4.7A)
None
 0.83A 4fzvA-4qg5A:
undetectable		 4fzvA-4qg5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 11 PRO A 369
LYS A 373
SER A 381
ASP A 501
ILE A 500
 None
 1.48A 4ktvC-4qg5A:
undetectable
4ktvD-4qg5A:
undetectable		 4ktvC-4qg5A:
21.11
4ktvD-4qg5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 PRO A 141
LEU A 144
HIS A  43
 None
 0.69A 4pevA-4qg5A:
undetectable		 4pevA-4qg5A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 7 THR A 402
GLY A 412
ALA A 415
ILE A 307
 None
 0.85A 4txnA-4qg5A:
undetectable		 4txnA-4qg5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 7 THR A 402
GLY A 412
ALA A 415
ILE A 307
 None
 0.90A 4txnB-4qg5A:
undetectable		 4txnB-4qg5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 7 THR A 402
GLY A 412
ALA A 415
ILE A 307
 None
 0.89A 4txnC-4qg5A:
undetectable		 4txnC-4qg5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 7 THR A 402
GLY A 412
ALA A 415
ILE A 307
 None
 0.87A 4txnD-4qg5A:
undetectable		 4txnD-4qg5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 TRP A 372
ILE A 407
SER A  95
 None
 1.03A 5gqbA-4qg5A:
undetectable		 5gqbA-4qg5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 LEU A 365
ALA A 364
LEU A 393
ILE A 500
GLY A 387
 None
 1.19A 5gs4A-4qg5A:
undetectable		 5gs4A-4qg5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 PRO A 261
SER A 118
GLU A 397
PHE A 400
GLY A 401
 None
MG  A 601 (-1.9A)
None
None
None
 1.36A 5il1A-4qg5A:
undetectable		 5il1A-4qg5A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 6 VAL A 250
LEU A 115
ILE A 130
PHE A 128
 None
 0.97A 5jw1A-4qg5A:
undetectable		 5jw1A-4qg5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 ILE A 407
VAL A 200
ILE A 307
ILE A 233
VAL A 296
 None
 0.63A 5mugA-4qg5A:
undetectable		 5mugA-4qg5A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 ILE A 307
GLY A 295
HIS A 218
PHE A 234
ALA A 415
 None
 1.28A 5n0xB-4qg5A:
undetectable		 5n0xB-4qg5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 7 ASP A 220
GLY A 227
GLY A 224
HIS A 223
 None
 0.98A 5n9xA-4qg5A:
3.0		 5n9xA-4qg5A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		3 / 3 ARG A 212
PHE A 294
LEU A 433
 None
 0.77A 5x1bC-4qg5A:
undetectable		 5x1bC-4qg5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		4 / 4 PHE A 298
LEU A 209
LEU A 417
VAL A 217
 None
 1.35A 5xxiA-4qg5A:
undetectable		 5xxiA-4qg5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 PHE A 234
VAL A 240
ILE A 307
VAL A 217
PHE A 294
 None
 1.32A 6ap6A-4qg5A:
undetectable		 6ap6A-4qg5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 PHE A 234
VAL A 240
ILE A 307
VAL A 217
PHE A 294
 None
 1.33A 6ap6B-4qg5A:
undetectable		 6ap6B-4qg5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 TYR A 132
LEU A  89
GLY A  56
SER A  73
VAL A  35
 None
 1.36A 6bxlB-4qg5A:
undetectable		 6bxlB-4qg5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 10 GLY A 227
GLY A 224
VAL A 219
ASP A 220
ILE A 233
 None
 1.13A 6exiA-4qg5A:
undetectable		 6exiA-4qg5A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 10 GLY A 227
GLY A 224
VAL A 219
ASP A 220
ILE A 233
 None
 1.10A 6exiB-4qg5A:
undetectable		 6exiB-4qg5A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 GLY A 227
GLY A 224
VAL A 219
ASP A 220
ILE A 233
 None
 1.11A 6exiC-4qg5A:
2.0
6exiD-4qg5A:
undetectable		 6exiC-4qg5A:
10.33
6exiD-4qg5A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 GLY A 227
GLY A 224
VAL A 219
ASP A 220
ILE A 233
 None
 1.10A 6exiC-4qg5A:
2.1
6exiD-4qg5A:
undetectable		 6exiC-4qg5A:
10.33
6exiD-4qg5A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE
(Leishmania
major) 		5 / 12 ASP A 501
ILE A 500
PRO A 369
LYS A 373
SER A 381
 None
 1.42A 6fbpA-4qg5A:
undetectable
6fbpB-4qg5A:
undetectable		 6fbpA-4qg5A:
9.84
6fbpB-4qg5A:
9.84