SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 5 THR A 418
GLU A 207
THR A 184
HIS A 411
 None
 1.48A 1d4fA-4qgkA:
3.9		 1d4fA-4qgkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 ILE A 349
ALA A 348
ILE A 371
GLU A 377
ILE A 375
 None
 1.35A 2dm6A-4qgkA:
2.6
2dm6B-4qgkA:
4.6		 2dm6A-4qgkA:
21.67
2dm6B-4qgkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.12A 2q6hA-4qgkA:
undetectable		 2q6hA-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.16A 2q72A-4qgkA:
1.2		 2q72A-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.15A 2qb4A-4qgkA:
undetectable		 2qb4A-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.15A 2qeiA-4qgkA:
2.1		 2qeiA-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLU A 207
PHE A 182
GLN A 120
PRO A 121
 None
 1.05A 2qqtA-4qgkA:
undetectable		 2qqtA-4qgkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 GLY A 400
GLY A 412
GLN A 120
PHE A 182
 None
 0.86A 2qwxA-4qgkA:
3.0
2qwxB-4qgkA:
undetectable		 2qwxA-4qgkA:
19.17
2qwxB-4qgkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 PHE A 364
ILE A 216
THR A 384
GLY A 232
 None
 0.88A 2v0mB-4qgkA:
undetectable		 2v0mB-4qgkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 TYR A 279
GLU A 280
THR A 240
 None
 0.92A 2y7hB-4qgkA:
undetectable		 2y7hB-4qgkA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 5 LEU A  72
GLN A  25
LEU A  27
GLU A  28
 None
 1.00A 3h5gA-4qgkA:
undetectable
3h5gB-4qgkA:
undetectable		 3h5gA-4qgkA:
5.56
3h5gB-4qgkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ARG A 290
PRO A 338
GLY A 334
PRO A 335
 None
 0.87A 3hcrA-4qgkA:
2.2		 3hcrA-4qgkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 GLN A  98
PRO A  99
VAL A  79
GLU A  77
 None
 1.40A 3huoA-4qgkA:
undetectable		 3huoA-4qgkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 PRO A 335
ILE A 261
TYR A 279
PHE A 302
 None
 1.16A 4g10A-4qgkA:
undetectable		 4g10A-4qgkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ASN A 164
GLU A 141
GLU A 138
GLU A 169
 None
 1.26A 4mj8C-4qgkA:
undetectable		 4mj8C-4qgkA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 GLU A 250
ILE A 216
CYH A 214
ILE A 339
 None
 0.95A 4xumA-4qgkA:
undetectable		 4xumA-4qgkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 GLY A 303
THR A 240
PRO A 335
 None
 0.66A 5v5zA-4qgkA:
undetectable		 5v5zA-4qgkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 PHE A 178
ILE A 181
ILE A 163
ALA A 110
 None
 0.72A 6b5vA-4qgkA:
undetectable
6b5vC-4qgkA:
undetectable		 6b5vA-4qgkA:
11.28
6b5vC-4qgkA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 PHE A 178
ILE A 181
ILE A 163
ALA A 110
 None
 0.72A 6b5vC-4qgkA:
0.0
6b5vD-4qgkA:
undetectable		 6b5vC-4qgkA:
11.28
6b5vD-4qgkA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 ALA A 110
PHE A 178
ILE A 181
ILE A 163
 None
 0.72A 6b5vB-4qgkA:
undetectable
6b5vD-4qgkA:
undetectable		 6b5vB-4qgkA:
11.28
6b5vD-4qgkA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 PHE A 333
ARG A 290
ILE A 283
ASN A 284
 None
 1.35A 6dhbA-4qgkA:
undetectable		 6dhbA-4qgkA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A  65
THR A 118
ILE A 119
LEU A 147
LEU A  42
 None
 1.29A 6ie8A-4qgkA:
undetectable		 6ie8A-4qgkA:
20.22