SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.02A 1os2A-4qgnA:
undetectable		 1os2A-4qgnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.02A 1os2D-4qgnA:
undetectable		 1os2D-4qgnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.05A 1utzA-4qgnA:
undetectable		 1utzA-4qgnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.08A 1utzB-4qgnA:
undetectable		 1utzB-4qgnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.03A 2hu6A-4qgnA:
undetectable		 2hu6A-4qgnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.05A 2ow9B-4qgnA:
undetectable		 2ow9B-4qgnA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.03A 2ozrC-4qgnA:
undetectable		 2ozrC-4qgnA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.01A 2ozrD-4qgnA:
undetectable		 2ozrD-4qgnA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.05A 3likA-4qgnA:
undetectable		 3likA-4qgnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.06A 3lilA-4qgnA:
undetectable		 3lilA-4qgnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.02A 3lkaA-4qgnA:
undetectable		 3lkaA-4qgnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.06A 5n5jA-4qgnA:
undetectable		 5n5jA-4qgnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.02A 5n5kA-4qgnA:
undetectable		 5n5kA-4qgnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 LYS A 204
HIS A 133
HIS A  88
 FE  A 201 (-2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.38A 5oexD-4qgnA:
undetectable		 5oexD-4qgnA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens) 		3 / 3 HIS A  88
HIS A 133
HIS A  90
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 201 (-3.3A)
 0.54A 5zrdA-4qgnA:
undetectable		 5zrdA-4qgnA:
16.21