SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qgo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 12 SER A 100
THR A 211
VAL A 210
LEU A 154
ILE A 150
None
1.27A 2fj1A-4qgoA:
undetectable
2fj1A-4qgoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 12 ARG A 215
TYR A 249
GLY A 130
LEU A 149
TYR A 214
None
1.30A 2nyrB-4qgoA:
undetectable
2nyrB-4qgoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 ASN A 244
VAL A 221
GLY A 130
ILE A 258
THR A 175
None
1.39A 3bexC-4qgoA:
undetectable
3bexD-4qgoA:
undetectable
3bexC-4qgoA:
18.55
3bexD-4qgoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 THR A 175
ASN A 244
VAL A 221
GLY A 130
ILE A 258
None
1.38A 3bexE-4qgoA:
undetectable
3bexF-4qgoA:
undetectable
3bexE-4qgoA:
18.55
3bexF-4qgoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 ASN A 244
VAL A 221
GLY A 130
ILE A 258
THR A 175
None
1.39A 3bf1A-4qgoA:
undetectable
3bf1B-4qgoA:
undetectable
3bf1A-4qgoA:
18.55
3bf1B-4qgoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 THR A 175
ASN A 244
VAL A 221
GLY A 130
ILE A 258
None
1.38A 3bf1C-4qgoA:
undetectable
3bf1D-4qgoA:
undetectable
3bf1C-4qgoA:
18.55
3bf1D-4qgoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 ASN A 244
VAL A 221
GLY A 130
ILE A 258
THR A 175
None
1.40A 3bf1E-4qgoA:
undetectable
3bf1F-4qgoA:
undetectable
3bf1E-4qgoA:
18.55
3bf1F-4qgoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 THR A 175
ASN A 244
VAL A 221
GLY A 130
ILE A 258
None
1.37A 3bf1E-4qgoA:
undetectable
3bf1F-4qgoA:
undetectable
3bf1E-4qgoA:
18.55
3bf1F-4qgoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 VAL A 171
ALA A 148
TYR A 152
ALA A 104
ASN A 170
None
None
SO4  A 303 (-4.7A)
None
None
1.41A 3qxyB-4qgoA:
undetectable
3qxyQ-4qgoA:
undetectable
3qxyB-4qgoA:
19.14
3qxyQ-4qgoA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
4 / 6 ASN A  75
TYR A 191
TYR A 192
LEU A 195
None
1.23A 4f8yA-4qgoA:
undetectable
4f8yB-4qgoA:
undetectable
4f8yA-4qgoA:
20.08
4f8yB-4qgoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
4 / 7 TYR A 191
TYR A 192
LEU A 195
ASN A  75
None
1.27A 4f8yC-4qgoA:
undetectable
4f8yD-4qgoA:
undetectable
4f8yC-4qgoA:
20.08
4f8yD-4qgoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
4 / 7 TYR A 192
TYR A 191
ASN A  67
TYR A  65
None
1.37A 4f8yC-4qgoA:
undetectable
4f8yD-4qgoA:
undetectable
4f8yC-4qgoA:
20.08
4f8yD-4qgoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 11 GLY A  68
ASN A  67
VAL A  66
GLN A  64
PRO A 243
None
1.30A 4j4vA-4qgoA:
undetectable
4j4vA-4qgoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 10 GLY A  68
ASN A  67
VAL A  66
GLN A  64
PRO A 243
None
1.27A 4j4vB-4qgoA:
undetectable
4j4vB-4qgoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae)
5 / 12 TYR A 192
GLY A 188
LEU A 154
LEU A 106
ALA A 229
None
1.11A 4wcxC-4qgoA:
undetectable
4wcxC-4qgoA:
19.25