SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 12 ILE A 309
GLN A 359
PRO A 277
ASN A 267
LEU A 270
 None
 1.25A 1dlsA-4qgrA:
undetectable		 1dlsA-4qgrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 12 GLY A 200
ILE A 167
LEU A 193
ASP A 162
VAL A  52
 None
None
None
PLP  A 403 (-2.7A)
None
 1.22A 1jg2A-4qgrA:
undetectable		 1jg2A-4qgrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 12 ILE A 309
GLN A 359
PRO A 277
ASN A 267
LEU A 270
 None
 1.17A 1u70A-4qgrA:
undetectable		 1u70A-4qgrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 12 GLY A 333
GLY A 334
SER A 340
LEU A 335
LEU A 321
 None
 1.19A 1ya4B-4qgrA:
undetectable		 1ya4B-4qgrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 8 MET A   1
LEU A 354
VAL A 365
GLY A 364
 None
 0.82A 2qd5A-4qgrA:
undetectable		 2qd5A-4qgrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 8 ILE A 366
HIS A 370
LEU A 270
ARG A 297
 None
 0.98A 2vdbA-4qgrA:
undetectable		 2vdbA-4qgrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 12 ILE A 309
GLN A 359
PRO A 277
ASN A 267
LEU A 270
 None
 1.13A 2w3mA-4qgrA:
undetectable		 2w3mA-4qgrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 ARG A 297
SER A 291
TYR A 108
PRO A 342
 None
 1.44A 3jqaC-4qgrA:
3.6		 3jqaC-4qgrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 ARG A 297
SER A 291
TYR A 108
PRO A 342
 None
 1.43A 3jqaD-4qgrA:
3.7		 3jqaD-4qgrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 GLY A 169
LEU A  47
TYR A  46
GLU A 253
 None
 1.13A 3w9tB-4qgrA:
undetectable		 3w9tB-4qgrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 GLY A 169
LEU A  47
TYR A  46
GLU A 253
 None
 1.12A 3w9tE-4qgrA:
undetectable		 3w9tE-4qgrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 GLY A 169
LEU A  47
TYR A  46
GLU A 253
 None
 1.12A 3w9tF-4qgrA:
undetectable		 3w9tF-4qgrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A 178
GLY A 183
LEU A  43
ASP A 137
ILE A 167
 None
 1.07A 3wdmD-4qgrA:
2.1		 3wdmD-4qgrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 7 GLY A 183
ILE A 160
VAL A 182
PRO A  65
 None
 1.08A 4e1vB-4qgrA:
undetectable		 4e1vB-4qgrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 7 PHE A 203
GLY A 200
THR A 185
ILE A 167
 None
 0.79A 4ejjA-4qgrA:
undetectable		 4ejjA-4qgrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 9 GLY A 199
ASP A  60
SER A 235
CYH A  55
GLY A 200
 None
 1.50A 4lb0A-4qgrA:
undetectable		 4lb0A-4qgrA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 7 PHE A  39
ALA A 201
LEU A  47
PHE A 203
 None
 1.08A 4uymB-4qgrA:
undetectable		 4uymB-4qgrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 ILE A 160
ALA A  86
THR A  87
VAL A  90
 None
PLP  A 403 ( 3.7A)
PLP  A 403 ( 4.9A)
None
 0.80A 5eclD-4qgrA:
undetectable		 5eclD-4qgrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 6 ILE A 160
ALA A  88
VAL A  90
VAL A 136
 None
None
None
PLP  A 403 ( 4.9A)
 0.89A 5eclD-4qgrA:
undetectable		 5eclD-4qgrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		5 / 12 LEU A  66
ILE A  71
GLY A  70
ILE A 160
VAL A 182
 None
 1.06A 6emuB-4qgrA:
undetectable		 6emuB-4qgrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE
(Brucella
abortus) 		4 / 5 ARG A 259
ALA A 258
TYR A 353
ILE A 251
 None
 1.44A 6g9bA-4qgrA:
undetectable
6g9bB-4qgrA:
0.0		 6g9bA-4qgrA:
17.31
6g9bB-4qgrA:
11.97