SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		3 / 3 GLU A  50
TYR A  91
PHE A  28
 None
 0.97A 1eqbB-4qh6A:
undetectable		 1eqbB-4qh6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		3 / 3 GLU A  50
TYR A  91
PHE A  28
 None
 0.96A 1eqbA-4qh6A:
undetectable		 1eqbA-4qh6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		3 / 3 GLU A  50
TYR A  91
PHE A  28
 None
 0.96A 1eqbC-4qh6A:
undetectable		 1eqbC-4qh6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		4 / 7 VAL A  34
LEU A  48
THR A  46
LEU A  45
 None
 0.77A 1jgsA-4qh6A:
undetectable		 1jgsA-4qh6A:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		7 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 162
 33L  A 301 (-3.7A)
33L  A 301 (-3.7A)
None
None
None
None
33L  A 301 (-4.7A)
 0.31A 1stfE-4qh6A:
32.2
1stfI-4qh6A:
1.7		 1stfE-4qh6A:
38.29
1stfI-4qh6A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 33L  A 301 (-3.7A)
33L  A 301 (-3.7A)
33L  A 301 (-4.7A)
None
 0.28A 3ai8A-4qh6A:
27.2		 3ai8A-4qh6A:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		5 / 12 SER A 183
TYR A  91
SER A  93
SER A  98
TRP A  26
 None
 1.43A 3ugrA-4qh6A:
undetectable		 3ugrA-4qh6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		5 / 12 LEU A 118
LEU A 129
ASN A 132
VAL A 137
ALA A 209
 None
 1.23A 4x1iB-4qh6A:
undetectable		 4x1iB-4qh6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		5 / 12 TYR A  89
THR A  85
LEU A  53
ALA A  82
THR A  59
 None
 1.49A 5ewjC-4qh6A:
undetectable
5ewjD-4qh6A:
undetectable		 5ewjC-4qh6A:
20.91
5ewjD-4qh6A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		3 / 3 TRP A  26
MET A  68
ASN A  69
 None
33L  A 301 (-3.6A)
None
 1.23A 5uc1B-4qh6A:
undetectable		 5uc1B-4qh6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4qh6 CRUZIPAIN
(Trypanosoma
cruzi) 		3 / 3 TRP A  26
MET A  68
ASN A  69
 None
33L  A 301 (-3.6A)
None
 1.24A 5uc1A-4qh6A:
undetectable		 5uc1A-4qh6A:
19.02