SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.42A 1os2A-4qhiA:
5.8		 1os2A-4qhiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.37A 1os2D-4qhiA:
5.7		 1os2D-4qhiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.42A 1uttA-4qhiA:
6.1		 1uttA-4qhiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.41A 1utzA-4qhiA:
6.1		 1utzA-4qhiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.41A 1utzB-4qhiA:
6.1		 1utzB-4qhiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.39A 1y93A-4qhiA:
6.0		 1y93A-4qhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.38A 2hu6A-4qhiA:
6.0		 2hu6A-4qhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		5 / 9 HIS A  69
GLU A  70
HIS A  73
HIS A  80
LEU A  99
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
None
 0.73A 2jihA-4qhiA:
2.5		 2jihA-4qhiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.53A 2ow9A-4qhiA:
6.0		 2ow9A-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.49A 2ow9B-4qhiA:
6.0		 2ow9B-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.53A 2ozrC-4qhiA:
6.0		 2ozrC-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.52A 2ozrD-4qhiA:
5.9		 2ozrD-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.51A 2ozrE-4qhiA:
2.7		 2ozrE-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A  69
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.34A 2ozrF-4qhiA:
6.0		 2ozrF-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  67
LEU A  71
ILE A  63
ARG A  64
 None
 1.05A 2rlfA-4qhiA:
undetectable
2rlfB-4qhiA:
undetectable		 2rlfA-4qhiA:
21.50
2rlfB-4qhiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  14
ILE A  29
ILE A  66
ALA A  39
LEU A  55
 None
 1.06A 3a50A-4qhiA:
undetectable		 3a50A-4qhiA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  14
ILE A  29
ILE A  66
ALA A  39
LEU A  55
 None
 1.11A 3a51E-4qhiA:
undetectable		 3a51E-4qhiA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		5 / 9 HIS A  69
GLU A  70
HIS A  73
HIS A  80
LEU A  99
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
None
 1.00A 3hy7A-4qhiA:
2.5		 3hy7A-4qhiA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.48A 3kecA-4qhiA:
6.1		 3kecA-4qhiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.42A 3likA-4qhiA:
6.1		 3likA-4qhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.42A 3lilA-4qhiA:
6.1		 3lilA-4qhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.37A 3ljgA-4qhiA:
5.9		 3ljgA-4qhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.42A 3lkaA-4qhiA:
6.0		 3lkaA-4qhiA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.60A 4a7bA-4qhiA:
5.4		 4a7bA-4qhiA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  71
LEU A  67
GLU A  70
ILE A  29
 None
None
GOL  A 202 (-3.1A)
None
 0.91A 4ww7A-4qhiA:
undetectable		 4ww7A-4qhiA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.41A 5n5jA-4qhiA:
6.0		 5n5jA-4qhiA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.42A 5n5kA-4qhiA:
6.1		 5n5kA-4qhiA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4qhi UNCHARACTERIZED
PROTEIN MJ1213
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  72
PHE A  84
LEU A  88
PHE A  65
 None
 0.96A 5x19C-4qhiA:
undetectable
5x19J-4qhiA:
undetectable		 5x19C-4qhiA:
16.09
5x19J-4qhiA:
19.09