SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		3 / 3 GLU A  43
ASP A  41
TYR A 109
 PEG  A 302 (-3.2A)
MET  A 301 ( 4.7A)
None
 0.79A 2yvlB-4qhqA:
undetectable		 2yvlB-4qhqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		4 / 8 THR A 108
LEU A 107
ALA A 105
SER A 104
 None
 1.01A 3kp6A-4qhqA:
undetectable		 3kp6A-4qhqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A 148
ALA A 198
ASN A 175
ILE A 154
ALA A 130
 None
 1.01A 4nkxA-4qhqA:
undetectable		 4nkxA-4qhqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A 148
ALA A 198
ASN A 175
ILE A 154
ALA A 130
 None
 0.96A 4nkxD-4qhqA:
undetectable		 4nkxD-4qhqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		4 / 8 ASN A 204
PHE A  85
SER A  84
TYR A 250
 MET  A 301 (-4.3A)
MET  A 301 (-4.7A)
None
None
 1.20A 5amiB-4qhqA:
undetectable		 5amiB-4qhqA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		5 / 12 SER A 111
ASN A 229
GLU A 221
SER A 225
VAL A 200
 MET  A 301 (-3.2A)
MET  A 301 (-3.0A)
None
None
None
 1.33A 5iqdC-4qhqA:
0.9		 5iqdC-4qhqA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		4 / 6 SER A  84
PHE A  85
ASP A  41
HIS A  87
 None
MET  A 301 (-4.7A)
MET  A 301 ( 4.7A)
MET  A 301 (-3.5A)
 1.18A 5om3A-4qhqA:
undetectable
5om3B-4qhqA:
undetectable		 5om3A-4qhqA:
15.77
5om3B-4qhqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4qhq LIPOPROTEIN
(Burkholderia
cenocepacia) 		4 / 4 VAL A  69
ALA A  73
PHE A  85
PHE A  65
 None
None
MET  A 301 (-4.7A)
None
 1.48A 6cbdA-4qhqA:
1.8		 6cbdA-4qhqA:
13.54