SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		3 / 3 GLU A 322
TYR A 191
PHE A 324
 SO4  A 508 (-3.6A)
None
PEG  A 520 (-3.7A)
 0.96A 1eqbB-4qhxA:
undetectable		 1eqbB-4qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		3 / 3 GLU A 322
TYR A 191
PHE A 324
 SO4  A 508 (-3.6A)
None
PEG  A 520 (-3.7A)
 0.96A 1eqbA-4qhxA:
undetectable		 1eqbA-4qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		3 / 3 GLU A 322
TYR A 191
PHE A 324
 SO4  A 508 (-3.6A)
None
PEG  A 520 (-3.7A)
 0.97A 1eqbD-4qhxA:
undetectable		 1eqbD-4qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		3 / 3 GLU A 322
TYR A 191
PHE A 324
 SO4  A 508 (-3.6A)
None
PEG  A 520 (-3.7A)
 0.97A 1eqbC-4qhxA:
undetectable		 1eqbC-4qhxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 10 CYH A 401
ASN A 375
LEU A 321
VAL A 335
ALA A 355
 None
 1.48A 1fpqA-4qhxA:
undetectable		 1fpqA-4qhxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 10 CYH A 401
GLY A 373
ASN A 375
LEU A 321
ALA A 355
 None
 1.42A 1fpqA-4qhxA:
undetectable		 1fpqA-4qhxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 6 ALA A 414
TRP A 349
ARG A 343
LEU A 415
 None
SO4  A 502 (-4.3A)
SO4  A 502 (-3.8A)
None
 1.21A 1gahA-4qhxA:
undetectable		 1gahA-4qhxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 5 PRO A  66
ILE A 109
ARG A 110
ASP A 108
 None
 1.33A 2rhmB-4qhxA:
undetectable		 2rhmB-4qhxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 8 ILE A  56
TYR A  60
VAL A  33
TYR A 330
 None
 1.16A 2xz5A-4qhxA:
undetectable
2xz5C-4qhxA:
undetectable		 2xz5A-4qhxA:
19.53
2xz5C-4qhxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 8 ILE A  56
TYR A  60
VAL A  33
TYR A 330
 None
 1.14A 2xz5C-4qhxA:
undetectable
2xz5D-4qhxA:
undetectable		 2xz5C-4qhxA:
19.53
2xz5D-4qhxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 7 ILE A  56
TYR A  60
VAL A  33
TYR A 330
 None
 1.15A 2xz5D-4qhxA:
undetectable
2xz5E-4qhxA:
undetectable		 2xz5D-4qhxA:
19.53
2xz5E-4qhxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 6 TYR A 314
PHE A 197
PHE A 216
PHE A 202
 None
 1.50A 3af3A-4qhxA:
undetectable		 3af3A-4qhxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 12 SER A 123
GLY A 128
GLY A 126
LEU A  94
GLY A 130
 None
CL  A 501 (-4.2A)
CL  A 501 ( 4.9A)
None
None
 1.06A 3axzA-4qhxA:
undetectable		 3axzA-4qhxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 7 GLY A 198
PHE A 197
PHE A 305
PHE A 216
 PEG  A 518 (-4.6A)
None
None
None
 1.15A 3ko0D-4qhxA:
undetectable
3ko0E-4qhxA:
undetectable		 3ko0D-4qhxA:
13.59
3ko0E-4qhxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 8 PHE A 305
PHE A 216
GLY A 198
PHE A 197
 None
None
PEG  A 518 (-4.6A)
None
 0.96A 3ko0O-4qhxA:
undetectable
3ko0Q-4qhxA:
undetectable		 3ko0O-4qhxA:
13.59
3ko0Q-4qhxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 10 HIS A 318
GLY A 164
TYR A 165
GLY A 203
ALA A 194
 PEG  A 518 (-4.5A)
None
None
None
None
 1.24A 3pp7B-4qhxA:
undetectable		 3pp7B-4qhxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 12 ARG A 157
GLY A 158
LEU A 369
SER A 392
GLU A 322
 PEG  A 520 ( 4.4A)
None
None
SO4  A 503 ( 4.4A)
SO4  A 508 (-3.6A)
 1.22A 3sxjA-4qhxA:
undetectable		 3sxjA-4qhxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 12 ARG A 157
GLY A 158
LEU A 369
SER A 392
GLU A 322
 PEG  A 520 ( 4.4A)
None
None
SO4  A 503 ( 4.4A)
SO4  A 508 (-3.6A)
 1.22A 3sxjB-4qhxA:
undetectable		 3sxjB-4qhxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		3 / 3 SER A 255
PHE A 222
LYS A 235
 None
 0.87A 3u88A-4qhxA:
undetectable		 3u88A-4qhxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 8 TYR A  60
VAL A  33
TYR A 330
ILE A  56
 None
 1.14A 4aftD-4qhxA:
undetectable
4aftE-4qhxA:
undetectable		 4aftD-4qhxA:
19.27
4aftE-4qhxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 8 TYR A  60
VAL A  33
TYR A 330
ILE A  56
 None
 1.13A 4bqtC-4qhxA:
undetectable
4bqtD-4qhxA:
undetectable		 4bqtC-4qhxA:
19.27
4bqtD-4qhxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 12 ILE A 132
LEU A 119
VAL A  83
LEU A 135
ILE A 107
 None
 0.91A 4g1bD-4qhxA:
undetectable		 4g1bD-4qhxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		5 / 12 ILE A 132
LEU A  73
VAL A  47
GLY A  46
GLY A  31
 None
 1.25A 5nnaA-4qhxA:
undetectable		 5nnaA-4qhxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4qhx UNCHARACTERIZED
PROTEIN
(Bacteroides
caccae) 		4 / 6 ARG A 157
GLY A 155
THR A 362
SER A 160
 PEG  A 520 ( 4.4A)
None
PEG  A 519 (-4.2A)
SO4  A 508 (-3.8A)
 1.06A 5ny7A-4qhxA:
undetectable		 5ny7A-4qhxA:
21.62