SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 6 TYR A   2
GLU A 105
ILE A 158
GLY A  30
 None
None
None
NO3  A 302 (-3.4A)
 1.14A 1maaB-4qi8A:
undetectable
1maaD-4qi8A:
undetectable		 1maaB-4qi8A:
18.30
1maaD-4qi8A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 12 VAL A 147
GLY A 144
TYR A 157
TYR A   2
HIS A 142
 None
None
CU  A 301 (-4.8A)
None
None
 1.34A 3hgiA-4qi8A:
undetectable		 3hgiA-4qi8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ARG A 139
ARG A  41
TRP A  99
 None
 1.39A 4b7nA-4qi8A:
undetectable		 4b7nA-4qi8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 11 ALA A 153
SER A 150
ILE A 196
ASN A 197
HIS A  72
 None
None
None
None
CU  A 301 (-3.2A)
 1.15A 4bb2A-4qi8A:
undetectable
4bb2B-4qi8A:
undetectable		 4bb2A-4qi8A:
20.94
4bb2B-4qi8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 TRP A  99
TRP A  92
THR A  93
 None
 1.16A 4bboB-4qi8A:
undetectable		 4bboB-4qi8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ARG A 139
ARG A  41
TRP A  99
 None
 1.47A 4cpzC-4qi8A:
undetectable		 4cpzC-4qi8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ARG A 139
ARG A  41
TRP A  99
 None
 1.43A 4cpzF-4qi8A:
undetectable		 4cpzF-4qi8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ARG A 139
ARG A  41
TRP A  99
 None
 1.40A 4cpzG-4qi8A:
undetectable		 4cpzG-4qi8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ARG A 139
ARG A  41
TRP A  99
 None
 1.48A 4cpzH-4qi8A:
undetectable		 4cpzH-4qi8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 6 PRO A 207
ILE A  40
TYR A  79
PHE A 181
 None
 1.17A 4g10A-4qi8A:
undetectable		 4g10A-4qi8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A  72
GLN A 155
TYR A 157
 CU  A 301 ( 3.1A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.6A)
CU  A 301 (-4.8A)
 0.83A 4gboA-4qi8A:
8.5		 4gboA-4qi8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		3 / 3 ASN A 176
PHE A 100
TYR A  79
 None
 0.85A 4u15A-4qi8A:
undetectable		 4u15A-4qi8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		4 / 5 HIS A   1
HIS A  72
GLN A 155
TYR A 157
 CU  A 301 ( 3.1A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.6A)
CU  A 301 (-4.8A)
 0.80A 5uizA-4qi8A:
8.4		 5uizA-4qi8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE
(Neurospora
crassa) 		5 / 11 PHE A   4
VAL A  70
THR A  63
ILE A  62
VAL A 125
 None
 1.19A 6hcoA-4qi8A:
undetectable
6hcoB-4qi8A:
undetectable		 6hcoA-4qi8A:
15.02
6hcoB-4qi8A:
15.02