SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 8 THR A  24
TRP A  19
LEU A 221
MET A 217
 None
 1.24A 1uw6A-4qidA:
undetectable
1uw6B-4qidA:
undetectable		 1uw6A-4qidA:
19.07
1uw6B-4qidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 8 THR A  24
TRP A  19
LEU A 221
MET A 217
 None
 1.26A 1uw6D-4qidA:
undetectable
1uw6E-4qidA:
undetectable		 1uw6D-4qidA:
19.07
1uw6E-4qidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 8 THR A  24
TRP A  19
LEU A 221
MET A 217
 None
 1.25A 1uw6G-4qidA:
undetectable
1uw6H-4qidA:
undetectable		 1uw6G-4qidA:
19.07
1uw6H-4qidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 8 THR A  24
TRP A  19
LEU A 221
MET A 217
 None
 1.24A 1uw6P-4qidA:
undetectable
1uw6Q-4qidA:
undetectable		 1uw6P-4qidA:
19.07
1uw6Q-4qidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 8 TRP A  19
LEU A 221
MET A 217
THR A  24
 None
 1.24A 1uw6P-4qidA:
undetectable
1uw6T-4qidA:
undetectable		 1uw6P-4qidA:
19.07
1uw6T-4qidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 12 ALA A 111
ALA A 181
PHE A 164
THR A 178
LEU A 107
 None
 1.17A 2zifB-4qidA:
undetectable		 2zifB-4qidA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 9 ARG A 183
ALA A 223
ILE A  56
GLY A 228
ILE A 230
 ACT  A 303 (-3.4A)
RET  A 301 (-3.6A)
None
None
None
 1.07A 3el4B-4qidA:
undetectable		 3el4B-4qidA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 12 LEU A  78
GLU A  75
VAL A  76
THR A 201
GLY A 211
 None
None
ACT  A 302 ( 4.5A)
None
None
 1.33A 4q15A-4qidA:
undetectable		 4q15A-4qidA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 12 ALA A 167
PHE A 179
THR A 175
ASN A 184
LEU A 160
 None
None
None
ACT  A 303 ( 4.8A)
None
 1.48A 4z7fC-4qidA:
2.2		 4z7fC-4qidA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 4 VAL A 218
ALA A 223
ILE A 192
THR A 189
 None
RET  A 301 (-3.6A)
None
None
 1.01A 5e4dB-4qidA:
undetectable		 5e4dB-4qidA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 12 SER A 152
PHE A 216
ILE A 122
ALA A 191
ILE A 192
 None
 1.02A 5veuB-4qidA:
1.8		 5veuB-4qidA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 12 LEU A  78
GLU A  75
VAL A  76
THR A 201
GLU A 212
 None
None
ACT  A 302 ( 4.5A)
None
None
 1.42A 5xipD-4qidA:
undetectable		 5xipD-4qidA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 10 LEU A 135
GLY A 203
GLY A  81
ARG A  82
VAL A  83
 None
 1.22A 6eu9B-4qidA:
undetectable		 6eu9B-4qidA:
12.89