SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4qik ROQUIN-1
(Homo
sapiens)
4 / 6 ALA A 252
LEU A 204
GLU A 282
LEU A 307
None
0.92A 1mt1D-4qikA:
undetectable
1mt1E-4qikA:
undetectable
1mt1D-4qikA:
16.04
1mt1E-4qikA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)
4qik ROQUIN-1
(Homo
sapiens)
5 / 12 LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
None
1.33A 2bxfB-4qikA:
2.5
2bxfB-4qikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
4qik ROQUIN-1
(Homo
sapiens)
3 / 3 ARG A 280
GLU A 201
GLN A 200
None
1.09A 2p16A-4qikA:
undetectable
2p16A-4qikA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4qik ROQUIN-1
(Homo
sapiens)
5 / 11 ASN A 351
ALA A 291
LEU A 171
GLN A 174
THR A 344
None
1.48A 3jwqB-4qikA:
undetectable
3jwqC-4qikA:
undetectable
3jwqB-4qikA:
23.10
3jwqC-4qikA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)
4qik ROQUIN-1
(Homo
sapiens)
5 / 10 SER A 304
ASP A 310
HIS A 313
ASP A 284
TRP A 184
None
None
None
None
CL  A 501 (-4.8A)
1.48A 4dfbB-4qikA:
0.5
4dfbB-4qikA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)
4qik ROQUIN-1
(Homo
sapiens)
5 / 12 SER A 304
ASP A 310
HIS A 313
ASP A 284
TRP A 184
None
None
None
None
CL  A 501 (-4.8A)
1.45A 4dfuB-4qikA:
undetectable
4dfuB-4qikA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)
4qik ROQUIN-1
(Homo
sapiens)
4 / 8 LEU A 137
VAL A 388
VAL A 392
GLN A 396
None
0.78A 4em2A-4qikA:
undetectable
4em2A-4qikA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)
4qik ROQUIN-1
(Homo
sapiens)
5 / 12 MET A 155
ILE A 363
LEU A 360
LEU A 106
LEU A 140
None
1.28A 4qynB-4qikA:
undetectable
4qynB-4qikA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)
4qik ROQUIN-1
(Homo
sapiens)
5 / 9 LEU A 381
LEU A 360
ILE A 363
SER A 160
ALA A 157
None
None
None
A  D  17 ( 4.1A)
None
1.47A 4z69A-4qikA:
2.7
4z69A-4qikA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
4qik ROQUIN-1
(Homo
sapiens)
5 / 12 LEU A 204
TYR A 276
LEU A 324
ILE A 320
HIS A 316
None
1.16A 5dv4A-4qikA:
undetectable
5dv4A-4qikA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)
4qik ROQUIN-1
(Homo
sapiens)
5 / 12 LEU A 183
SER A 305
SER A 304
LEU A 307
MET A 317
None
CL  A 505 (-3.7A)
None
None
None
1.11A 5mwyA-4qikA:
undetectable
5mwyA-4qikA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)
4qik ROQUIN-1
(Homo
sapiens)
5 / 10 LEU A 161
VAL A 387
LEU A 391
PHE A 330
GLU A 168
None
1.34A 5tixB-4qikA:
undetectable
5tixB-4qikA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
4qik ROQUIN-1
(Homo
sapiens)
4 / 6 TRP A 184
GLY A 295
ALA A 186
LEU A 183
CL  A 501 (-4.8A)
None
CL  A 508 (-3.7A)
None
0.96A 6fosA-4qikA:
undetectable
6fosA-4qikA:
15.11