SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qiq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 5 THR A 117
THR A 196
GLU A 106
THR A 110
 None
 1.36A 1d4fB-4qiqA:
undetectable		 1d4fB-4qiqA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 11 PHE A 363
ALA A 372
LEU A 373
ILE A 313
ALA A 314
 None
 0.90A 1ha2A-4qiqA:
undetectable		 1ha2A-4qiqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 11 PHE A 363
LEU A 373
SER A 310
ILE A 313
ALA A 314
 None
 0.94A 1ha2A-4qiqA:
undetectable		 1ha2A-4qiqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 TYR A 445
ILE A 293
ALA A 362
MET A 356
LEU A 307
 None
 0.96A 1kiaC-4qiqA:
undetectable		 1kiaC-4qiqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 TYR A 445
VAL A 380
ALA A 362
MET A 356
LEU A 307
 None
 1.18A 1kiaD-4qiqA:
undetectable		 1kiaD-4qiqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 9 GLY A 449
GLY A 442
PHE A 443
SER A 444
GLY A 360
 None
 1.29A 1l4nA-4qiqA:
undetectable		 1l4nA-4qiqA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 TYR A 445
ILE A 293
ALA A 362
MET A 356
LEU A 307
 None
 0.91A 1nbhB-4qiqA:
undetectable		 1nbhB-4qiqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 11 ASP A  27
GLY A  21
GLY A  20
SER A 147
PHE A 213
 None
 1.27A 1w76A-4qiqA:
undetectable		 1w76A-4qiqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 10 TYR A 298
TYR A 179
GLY A  25
THR A  28
ALA A  29
 None
 1.13A 2coiA-4qiqA:
undetectable
2coiB-4qiqA:
undetectable		 2coiA-4qiqA:
20.24
2coiB-4qiqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 10 TYR A 298
TYR A 179
GLY A  25
THR A  28
ALA A  29
 None
 1.16A 2coiA-4qiqA:
undetectable
2coiB-4qiqA:
undetectable		 2coiA-4qiqA:
20.24
2coiB-4qiqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 11 TYR A 179
GLY A  25
THR A  28
ALA A  29
VAL A 321
 None
 1.32A 2cojA-4qiqA:
undetectable
2cojB-4qiqA:
undetectable		 2cojA-4qiqA:
20.24
2cojB-4qiqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 11 TYR A 298
TYR A 179
GLY A  25
THR A  28
ALA A  29
 None
 1.19A 2cojA-4qiqA:
undetectable
2cojB-4qiqA:
undetectable		 2cojA-4qiqA:
20.24
2cojB-4qiqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 7 ILE A 280
ARG A 404
PHE A 399
ILE A 398
 None
 1.16A 2q6hA-4qiqA:
0.0		 2q6hA-4qiqA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 7 ILE A 134
LEU A  74
LEU A  94
GLY A 136
 None
 0.97A 2qqcD-4qiqA:
undetectable
2qqcE-4qiqA:
undetectable		 2qqcD-4qiqA:
14.36
2qqcE-4qiqA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 8 ILE A 134
LEU A  74
LEU A  94
GLY A 136
 None
 0.88A 2qqdB-4qiqA:
undetectable
2qqdC-4qiqA:
undetectable		 2qqdB-4qiqA:
14.09
2qqdC-4qiqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 6 LEU A  56
GLY A  58
LEU A  48
SER A  49
 None
 0.96A 3aiaA-4qiqA:
undetectable		 3aiaA-4qiqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 6 LEU A 142
GLY A 137
LEU A 146
SER A 147
 None
 0.92A 3aiaA-4qiqA:
undetectable		 3aiaA-4qiqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 THR A 425
VAL A 295
VAL A 291
GLY A 292
ILE A 447
 None
 1.06A 3bf1A-4qiqA:
undetectable
3bf1B-4qiqA:
undetectable		 3bf1A-4qiqA:
20.00
3bf1B-4qiqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 11 ILE A  90
ALA A  91
ALA A  92
LEU A 142
ALA A 143
 None
 1.00A 3fc6A-4qiqA:
undetectable		 3fc6A-4qiqA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 4 ILE A 112
SER A 111
ASP A 197
ASP A 190
 None
 1.48A 4krhB-4qiqA:
undetectable		 4krhB-4qiqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 ALA A 456
GLY A 351
GLY A 348
THR A 361
GLY A 449
 None
 1.03A 4n48B-4qiqA:
undetectable		 4n48B-4qiqA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 GLY A 139
GLY A  71
ILE A  90
SER A 144
ALA A 143
 None
 1.05A 4qtuD-4qiqA:
undetectable		 4qtuD-4qiqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 VAL A  30
GLY A 137
ILE A 138
ILE A  69
TRP A 416
 None
 1.31A 4xucA-4qiqA:
undetectable		 4xucA-4qiqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 VAL A  30
GLY A 137
ILE A 138
ILE A  69
TRP A 416
 None
 1.28A 4xudA-4qiqA:
undetectable		 4xudA-4qiqA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		4 / 4 VAL A 140
ILE A  69
ASN A 419
VAL A 412
 None
 1.28A 5ajqA-4qiqA:
undetectable		 5ajqA-4qiqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 GLY A  58
PHE A  42
VAL A  43
PHE A 129
ALA A  64
 None
 1.28A 5n0xB-4qiqA:
undetectable		 5n0xB-4qiqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4qiq D-XYLOSE-PROTON
SYMPORTER
(Escherichia
coli) 		5 / 12 ILE A  13
GLY A  20
ALA A  17
ALA A 143
PHE A  95
 None
 1.03A 5zw4A-4qiqA:
undetectable		 5zw4A-4qiqA:
17.93