SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.40A 1d4fA-4qiwB:
undetectable		 1d4fA-4qiwB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.40A 1d4fB-4qiwB:
undetectable		 1d4fB-4qiwB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.38A 1d4fC-4qiwB:
undetectable		 1d4fC-4qiwB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.37A 1d4fD-4qiwB:
undetectable		 1d4fD-4qiwB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		4 / 6 VAL C 300
VAL C  67
SER C  71
GLN C  70
 None
 1.11A 1e7aB-4qiwC:
2.7		 1e7aB-4qiwC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 4 GLU B 470
MET B 433
LEU B 436
SER B 437
 None
 1.31A 1ee2B-4qiwB:
undetectable		 1ee2B-4qiwB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 12 THR A 668
ALA A 747
ILE A 680
LEU B 928
ARG B 958
 None
 1.37A 1eiiA-4qiwA:
undetectable		 1eiiA-4qiwA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 GLY A 511
LEU A 514
THR A 515
VAL A 653
 None
 1.11A 1ekjF-4qiwA:
undetectable
1ekjG-4qiwA:
undetectable		 1ekjF-4qiwA:
13.60
1ekjG-4qiwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis) 		5 / 12 ILE C  58
VAL A 860
ARG H  65
ALA C  68
ILE C 286
 None
 1.02A 1epbB-4qiwC:
undetectable		 1epbB-4qiwC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 1.01A 1eqhA-4qiwB:
0.8		 1eqhA-4qiwB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 1.04A 1eqhB-4qiwB:
0.8		 1eqhB-4qiwB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 12 ILE C  72
ALA C  69
ALA C  68
LEU C 307
LEU A 845
 None
 0.96A 1fm9A-4qiwC:
undetectable		 1fm9A-4qiwC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 4 VAL B 628
TRP B 631
TRP B 463
 None
 1.35A 1gmkA-4qiwB:
undetectable
1gmkB-4qiwB:
undetectable		 1gmkA-4qiwB:
0.98
1gmkB-4qiwB:
0.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 4 VAL A 895
TRP A 883
TRP A 570
 None
 1.37A 1gmkA-4qiwA:
undetectable
1gmkB-4qiwA:
undetectable		 1gmkA-4qiwA:
2.30
1gmkB-4qiwA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis) 		4 / 7 TYR N  43
ILE B 992
GLU B 972
LEU B 961
 None
 1.08A 1j96B-4qiwN:
undetectable		 1j96B-4qiwN:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 12 ILE C  72
ALA C  69
ALA C  68
LEU C 307
LEU A 845
 None
 0.97A 1k74A-4qiwC:
undetectable		 1k74A-4qiwC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ARG B  93
ASP B  36
ASN B  39
GLU B 165
 None
 1.28A 1rjdA-4qiwB:
undetectable		 1rjdA-4qiwB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ARG B  93
ASP B  36
ASN B  39
GLU B 165
 None
 1.25A 1rjdB-4qiwB:
undetectable		 1rjdB-4qiwB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ARG B  93
ASP B  36
ASN B  39
GLU B 165
 None
 1.24A 1rjdC-4qiwB:
undetectable		 1rjdC-4qiwB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 8 SER B 746
ARG B 749
PHE N   8
ASN B 743
 None
 1.26A 1rs6B-4qiwB:
undetectable		 1rs6B-4qiwB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 8 SER B 746
ARG B 749
PHE N   8
ASN B 743
 None
 1.11A 1rs7B-4qiwB:
undetectable		 1rs7B-4qiwB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 10 GLY A 511
ASP A 506
ILE A 504
GLY A 754
ALA A 502
 None
 1.06A 1sh9B-4qiwA:
undetectable		 1sh9B-4qiwA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 TYR B  38
ARG B 136
GLN B  74
 None
 0.92A 1tw4A-4qiwB:
undetectable		 1tw4A-4qiwB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.33A 1v8bA-4qiwB:
undetectable		 1v8bA-4qiwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.31A 1v8bB-4qiwB:
undetectable		 1v8bB-4qiwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.33A 1v8bC-4qiwB:
undetectable		 1v8bC-4qiwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.37A 1v8bD-4qiwB:
undetectable		 1v8bD-4qiwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 GLN A 612
ILE A 611
TYR A 610
 None
 0.62A 1vifA-4qiwA:
undetectable		 1vifA-4qiwA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 12 ALA A 460
GLY A 464
ILE A 332
LEU B 997
TYR B 994
 None
 1.08A 1x1aA-4qiwA:
undetectable		 1x1aA-4qiwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 ALA B 745
ASN B 743
ILE B 742
ASP B 911
 None
 1.14A 1yc2D-4qiwB:
undetectable		 1yc2D-4qiwB:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ARG B 166
GLN B 425
ASP B 428
HIS B 438
ARG B 441
 None
 0.93A 1ynnC-4qiwB:
27.0		 1ynnC-4qiwB:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 GLY A 734
GLU A 738
ASN A 732
 None
 0.69A 1zq9A-4qiwA:
undetectable		 1zq9A-4qiwA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 8 SER B 746
ARG B 749
PHE N   8
ASN B 743
 None
 1.24A 1zzqA-4qiwB:
undetectable		 1zzqA-4qiwB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 8 SER B 746
ARG B 749
PHE N   8
ASN B 743
 None
 1.21A 1zzqB-4qiwB:
undetectable		 1zzqB-4qiwB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 8 SER B 746
ARG B 749
PHE N   8
ASP B 911
 None
 1.13A 1zzuA-4qiwB:
undetectable		 1zzuA-4qiwB:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 11 ARG B 166
GLN B 425
ASP B 428
HIS B 438
PRO B 472
 None
 0.69A 2a68C-4qiwB:
22.4
2a68F-4qiwB:
0.2		 2a68C-4qiwB:
31.05
2a68F-4qiwB:
18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 11 ARG B 166
GLN B 425
ASP B 428
HIS B 438
PRO B 472
 None
 0.80A 2a68M-4qiwB:
26.0		 2a68M-4qiwB:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 11 ARG B 166
GLN B 425
ASP B 428
HIS B 438
PRO B 472
 None
 0.71A 2a69C-4qiwB:
22.5
2a69F-4qiwB:
0.0		 2a69C-4qiwB:
31.05
2a69F-4qiwB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 12 ALA C  68
ALA C  69
ASN A 847
LEU A 845
LEU C 307
 None
 0.93A 2aclA-4qiwC:
undetectable
2aclE-4qiwC:
undetectable		 2aclA-4qiwC:
22.28
2aclE-4qiwC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 11 GLY A 734
ALA A 733
ILE A 687
GLY A 770
ILE A 683
 None
 0.89A 2b60B-4qiwA:
undetectable		 2b60B-4qiwA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 HIS A 438
PHE A 424
ARG A 441
GLY A 344
 None
 1.45A 2i30A-4qiwA:
2.9		 2i30A-4qiwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 MET B 974
PRO B 902
LEU B 939
ALA B 937
ILE B 989
 None
 1.24A 2jjpA-4qiwB:
undetectable		 2jjpA-4qiwB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		3 / 3 SER B 846
HIS B 999
ASP A 463
 None
None
MG  A1001 (-3.0A)
 0.82A 2oxtA-4qiwB:
undetectable		 2oxtA-4qiwB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 SER B 100
ARG B 122
ILE B 123
PHE B 359
 None
 1.13A 2q6hA-4qiwB:
undetectable		 2q6hA-4qiwB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 7 HIS F  47
ARG E 100
GLU E  88
PHE F  51
 None
 1.20A 2q6uA-4qiwF:
undetectable		 2q6uA-4qiwF:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 8 ARG C 282
PRO A 879
SER A 882
GLY A 873
 None
 1.06A 2qd3A-4qiwC:
undetectable		 2qd3A-4qiwC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		3 / 3 GLY D 109
ASP D 108
SER D 106
 None
 0.59A 2qhfA-4qiwD:
undetectable		 2qhfA-4qiwD:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 THR B 413
ALA B 410
LEU B 358
LEU B 355
ILE B 171
 None
 1.12A 2qxsA-4qiwB:
undetectable		 2qxsA-4qiwB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 THR B 413
ALA B 410
LEU B 358
LEU B 355
ILE B 171
 None
 1.11A 2qxsB-4qiwB:
undetectable		 2qxsB-4qiwB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 LEU B 215
ASP B 263
MET B 232
LEU B 320
 None
 1.32A 2qxsB-4qiwB:
undetectable		 2qxsB-4qiwB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		5 / 12 ASP E  39
VAL E  45
ILE F   2
GLY F   3
ILE E  37
 None
 1.01A 2r5pA-4qiwE:
undetectable		 2r5pA-4qiwE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		5 / 12 ASP E  39
VAL E  45
ILE F   2
GLY F   3
ILE E  37
 None
 1.00A 2r5pC-4qiwE:
undetectable		 2r5pC-4qiwE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 SER B 707
THR B 924
ILE B 709
GLY B 671
 None
 0.81A 2v0mB-4qiwB:
undetectable		 2v0mB-4qiwB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 HIS A 490
MET A 880
MET A 433
 None
 1.36A 2vj1A-4qiwA:
undetectable		 2vj1A-4qiwA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 THR B 430
GLY B 694
LEU B 426
THR B 692
 None
 1.03A 2vl2B-4qiwB:
undetectable		 2vl2B-4qiwB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		4 / 8 TYR E   2
LEU F  20
LEU E  75
ALA E  47
 None
 1.08A 2wekA-4qiwE:
undetectable		 2wekA-4qiwE:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 GLY A 824
ALA A 821
MET A 822
LEU B 458
 None
 0.81A 2wekB-4qiwA:
undetectable		 2wekB-4qiwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 PHE B 949
TYR A 817
ALA A 800
ALA B 647
MET A 822
 None
 1.26A 2x2nA-4qiwB:
undetectable		 2x2nA-4qiwB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 PHE B 949
TYR A 817
ALA A 800
ALA B 647
MET A 822
 None
 1.24A 2x2nB-4qiwB:
undetectable		 2x2nB-4qiwB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 ARG A 843
GLY A 839
SER A 434
 None
 0.64A 2xctB-4qiwA:
undetectable		 2xctB-4qiwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		4 / 6 ARG A 892
ILE C  45
GLU C  33
TYR C  35
 None
 1.30A 2ya7C-4qiwA:
undetectable		 2ya7C-4qiwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 6 ILE C  58
MET A 880
PRO A 879
VAL A 421
 None
 1.10A 2ygoA-4qiwC:
undetectable		 2ygoA-4qiwC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 10 GLY B 526
TYR B 569
ASN B 571
ARG B 347
THR B 179
 None
 1.10A 2z71A-4qiwB:
0.0
2z71C-4qiwB:
0.0		 2z71A-4qiwB:
15.20
2z71C-4qiwB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.34A 2zj0A-4qiwB:
undetectable		 2zj0A-4qiwB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 PRO B 468
GLU A 816
TYR A 817
 None
 0.71A 2zmbA-4qiwB:
undetectable		 2zmbA-4qiwB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 PHE B  41
TYR B  38
ILE B 407
GLU B 125
ALA B 134
 None
 1.35A 3apwA-4qiwB:
undetectable		 3apwA-4qiwB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 PRO A 199
LEU A 200
ARG A 105
 None
 0.65A 3aqiB-4qiwA:
undetectable		 3aqiB-4qiwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis) 		3 / 3 LEU C 314
VAL H  80
ARG H  77
 None
 0.74A 3b0wB-4qiwC:
undetectable		 3b0wB-4qiwC:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.31A 3ce6A-4qiwB:
undetectable		 3ce6A-4qiwB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.30A 3ce6C-4qiwB:
undetectable		 3ce6C-4qiwB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 4 THR B 443
VAL B 167
GLY B 414
THR B 413
 None
 1.08A 3cflA-4qiwB:
undetectable		 3cflA-4qiwB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 VAL A 279
THR A 280
ILE A 283
THR A 163
 None
 0.83A 3deuA-4qiwA:
undetectable		 3deuA-4qiwA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 TYR B 138
TYR B  99
ILE B 128
 None
 0.72A 3eteA-4qiwB:
undetectable
3eteB-4qiwB:
undetectable		 3eteA-4qiwB:
18.84
3eteB-4qiwB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.11A 3fhjA-4qiwC:
undetectable		 3fhjA-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.23A 3fhjA-4qiwC:
undetectable		 3fhjA-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.11A 3fhjB-4qiwC:
undetectable		 3fhjB-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.24A 3fhjB-4qiwC:
undetectable		 3fhjB-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.11A 3fhjC-4qiwC:
undetectable		 3fhjC-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.23A 3fhjC-4qiwC:
undetectable		 3fhjC-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.11A 3fhjD-4qiwC:
3.1		 3fhjD-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.24A 3fhjD-4qiwC:
3.1		 3fhjD-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.11A 3fhjE-4qiwC:
2.7		 3fhjE-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.24A 3fhjE-4qiwC:
2.7		 3fhjE-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.11A 3fhjF-4qiwC:
undetectable		 3fhjF-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.24A 3fhjF-4qiwC:
undetectable		 3fhjF-4qiwC:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.01A 3fi0A-4qiwC:
undetectable		 3fi0A-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.16A 3fi0A-4qiwC:
undetectable		 3fi0A-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.01A 3fi0C-4qiwC:
undetectable		 3fi0C-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.16A 3fi0C-4qiwC:
undetectable		 3fi0C-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.03A 3fi0D-4qiwC:
undetectable		 3fi0D-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.21A 3fi0D-4qiwC:
undetectable		 3fi0D-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 7 GLY C  65
HIS C 304
VAL A 854
GLN A 869
 None
 0.85A 3fi0E-4qiwC:
undetectable		 3fi0E-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.03A 3fi0F-4qiwC:
undetectable		 3fi0F-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.20A 3fi0F-4qiwC:
undetectable		 3fi0F-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.02A 3fi0H-4qiwC:
undetectable		 3fi0H-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.15A 3fi0H-4qiwC:
undetectable		 3fi0H-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.00A 3fi0J-4qiwC:
undetectable		 3fi0J-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.16A 3fi0J-4qiwC:
undetectable		 3fi0J-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.03A 3fi0K-4qiwC:
undetectable		 3fi0K-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.17A 3fi0K-4qiwC:
undetectable		 3fi0K-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.09A 3fi0L-4qiwC:
undetectable		 3fi0L-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.18A 3fi0L-4qiwC:
undetectable		 3fi0L-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.07A 3fi0M-4qiwC:
undetectable		 3fi0M-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.17A 3fi0M-4qiwC:
undetectable		 3fi0M-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 0.98A 3fi0N-4qiwC:
undetectable		 3fi0N-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.13A 3fi0N-4qiwC:
undetectable		 3fi0N-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.09A 3fi0O-4qiwC:
undetectable		 3fi0O-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.21A 3fi0O-4qiwC:
undetectable		 3fi0O-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 GLY C  65
HIS C 304
VAL A 854
VAL A 860
GLN A 869
 None
 1.10A 3fi0R-4qiwC:
undetectable		 3fi0R-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 9 HIS C 304
ILE C  58
VAL A 854
VAL A 860
GLN A 869
 None
 1.22A 3fi0R-4qiwC:
undetectable		 3fi0R-4qiwC:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		5 / 10 ALA D  93
LEU D 123
ILE D  59
LEU D  63
PHE D 131
 None
 0.95A 3fl9A-4qiwD:
undetectable		 3fl9A-4qiwD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		5 / 9 ALA D  93
LEU D 123
ILE D  59
LEU D  63
PHE D 131
 None
 1.01A 3fl9D-4qiwD:
undetectable		 3fl9D-4qiwD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		5 / 10 ALA D  93
LEU D 123
ILE D  59
LEU D  63
PHE D 131
 None
 0.95A 3fl9E-4qiwD:
undetectable		 3fl9E-4qiwD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		5 / 10 ALA D  93
LEU D 123
ILE D  59
LEU D  63
PHE D 131
 None
 0.97A 3fl9F-4qiwD:
undetectable		 3fl9F-4qiwD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.33A 3g1uC-4qiwB:
undetectable		 3g1uC-4qiwB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.26A 3glqA-4qiwB:
undetectable		 3glqA-4qiwB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.29A 3glqB-4qiwB:
undetectable		 3glqB-4qiwB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 749
THR A 753
LYS A 664
PHE A 666
LYS A 655
 None
 1.29A 3ijdB-4qiwA:
undetectable		 3ijdB-4qiwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.20A 3jx1A-4qiwD:
undetectable
3jx1B-4qiwD:
undetectable		 3jx1A-4qiwD:
20.75
3jx1B-4qiwD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis) 		4 / 5 ASP B 852
TYR P  36
PRO B 802
GLU B 803
 None
 1.16A 3l2uA-4qiwB:
undetectable		 3l2uA-4qiwB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis) 		4 / 5 ASP B 852
TYR P  36
PRO B 802
GLU B 803
 None
 1.16A 3l2wA-4qiwB:
undetectable		 3l2wA-4qiwB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.24A 3n58A-4qiwB:
undetectable		 3n58A-4qiwB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 7 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.23A 3n61A-4qiwD:
undetectable
3n61B-4qiwD:
undetectable		 3n61A-4qiwD:
20.52
3n61B-4qiwD:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 8 SER B 746
ARG B 749
PHE N   8
ASN B 743
ASP B 911
 None
 1.42A 3n62B-4qiwB:
undetectable		 3n62B-4qiwB:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 1.02A 3n8wA-4qiwB:
0.6		 3n8wA-4qiwB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 VAL B 868
VAL B 806
SER B 804
 None
 0.74A 3n8xB-4qiwB:
undetectable		 3n8xB-4qiwB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 8 PHE A 462
VAL B 891
GLY B 879
GLY A 464
 None
 0.72A 3n9jB-4qiwA:
undetectable		 3n9jB-4qiwA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.19A 3nlyA-4qiwD:
undetectable
3nlyB-4qiwD:
undetectable		 3nlyA-4qiwD:
20.75
3nlyB-4qiwD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 VAL B 914
ILE B 892
MET B 697
ARG B 667
 None
 1.23A 3oezA-4qiwB:
undetectable		 3oezA-4qiwB:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
(Thermococcus
kodakarensis) 		5 / 9 ASP E  63
GLY E  64
ALA E  65
ILE E  13
GLY K  23
 None
 1.00A 3ogpB-4qiwE:
undetectable		 3ogpB-4qiwE:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
(Thermococcus
kodakarensis) 		5 / 12 ASP E  63
GLY E  64
ALA E  65
ILE E  13
GLY K  23
 None
 0.92A 3ogqB-4qiwE:
undetectable		 3ogqB-4qiwE:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 5 SER H  67
ARG C 294
ASP C 301
THR A 887
 None
 1.46A 3okxA-4qiwH:
undetectable		 3okxA-4qiwH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 5 SER H  67
ARG C 294
ASP C 301
THR A 887
 None
 1.44A 3okxB-4qiwH:
undetectable		 3okxB-4qiwH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 340
ALA A 502
HIS A 431
GLY A 498
PRO A 499
 None
 1.06A 3ozwB-4qiwA:
2.6		 3ozwB-4qiwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 340
ALA A 502
LEU A 450
GLY A 498
PRO A 499
 None
 0.97A 3ozwB-4qiwA:
2.6		 3ozwB-4qiwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.17A 3rqlA-4qiwD:
undetectable
3rqlB-4qiwD:
undetectable		 3rqlA-4qiwD:
20.75
3rqlB-4qiwD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 0.98A 3rr3A-4qiwB:
undetectable		 3rr3A-4qiwB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 0.98A 3rr3B-4qiwB:
undetectable		 3rr3B-4qiwB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		3 / 3 PHE D  55
GLN D 127
PHE B 757
 None
 0.82A 3rv5A-4qiwD:
undetectable		 3rv5A-4qiwD:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		4 / 4 ASP F  88
ASP F  91
ARG F 119
ASP F 116
 None
 1.50A 3sdvA-4qiwF:
0.4		 3sdvA-4qiwF:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 TYR B 994
LEU B 681
ARG B 996
 None
 0.66A 3sufB-4qiwB:
undetectable		 3sufB-4qiwB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		5 / 10 PHE D  16
PHE D   4
ALA D 239
THR D  32
PHE D  25
 None
 1.44A 3t3qD-4qiwD:
undetectable		 3t3qD-4qiwD:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 812
HIS A 820
THR A 805
ARG A 799
 None
 1.46A 3thrB-4qiwA:
undetectable		 3thrB-4qiwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 LEU B 427
ARG B 429
ILE B 652
ARG B 440
 None
 1.16A 3ticA-4qiwB:
undetectable		 3ticA-4qiwB:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 11 ALA D 133
LEU D 104
LEU D  68
ILE D 118
ARG N   6
 None
 1.09A 3tqbA-4qiwD:
undetectable		 3tqbA-4qiwD:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 4 PRO A 199
LEU A 200
ILE A 106
ARG A 105
 None
 1.13A 3w1wA-4qiwA:
undetectable		 3w1wA-4qiwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 9 ALA C  63
GLY C  65
ASP A 851
LEU A 849
ILE A 846
 None
 1.40A 3wdmA-4qiwC:
undetectable		 3wdmA-4qiwC:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 637
TYR A 626
HIS A 507
VAL A 660
 None
 1.23A 4a97I-4qiwA:
2.6		 4a97I-4qiwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		3 / 3 TYR E   2
MET E   1
ILE F  77
 None
 0.57A 4c8bB-4qiwE:
undetectable		 4c8bB-4qiwE:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.26A 4capA-4qiwD:
undetectable
4capB-4qiwD:
undetectable		 4capA-4qiwD:
20.75
4capB-4qiwD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.23A 4d32A-4qiwD:
undetectable
4d32B-4qiwD:
undetectable		 4d32A-4qiwD:
20.75
4d32B-4qiwD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ASP B 911
TYR B 731
THR A 667
ILE B 908
VAL B 725
 None
 1.45A 4eb6B-4qiwB:
undetectable
4eb6C-4qiwB:
undetectable		 4eb6B-4qiwB:
18.16
4eb6C-4qiwB:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 8 GLU B 763
ASN B  96
GLY B 163
SER B 164
 None
 1.02A 4f93B-4qiwB:
undetectable		 4f93B-4qiwB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 THR B 669
GLY B 673
PRO B 472
GLY B 474
 None
 0.89A 4fjpA-4qiwB:
undetectable		 4fjpA-4qiwB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 GLN B 488
THR B 490
THR B 491
 None
 0.65A 4fu9A-4qiwB:
undetectable		 4fu9A-4qiwB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 GLN B 488
THR B 490
THR B 491
 None
 0.64A 4fufA-4qiwB:
undetectable		 4fufA-4qiwB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		3 / 3 PHE D  47
VAL P  46
GLU D  57
 None
 0.75A 4fvqA-4qiwD:
undetectable		 4fvqA-4qiwD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 661
THR A 657
VAL B 728
SER A 509
 None
 1.17A 4iaqA-4qiwA:
3.8		 4iaqA-4qiwA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 8 THR A 835
ALA A 832
LEU A 828
THR A 831
 None
 0.83A 4ik7B-4qiwA:
undetectable		 4ik7B-4qiwA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis) 		5 / 12 ILE C  20
TYR H  76
PHE A 870
LEU H  30
LEU H  40
 None
 1.36A 4j03A-4qiwC:
2.1		 4j03A-4qiwC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis) 		4 / 7 ARG B 792
VAL P  42
PHE B 801
GLU B 803
 None
 1.36A 4jseA-4qiwB:
1.3
4jseB-4qiwB:
undetectable		 4jseA-4qiwB:
15.90
4jseB-4qiwB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis) 		4 / 7 PHE B 801
GLU B 803
ARG B 792
VAL P  42
 None
 1.33A 4jseA-4qiwB:
1.3
4jseB-4qiwB:
undetectable		 4jseA-4qiwB:
15.90
4jseB-4qiwB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 10 PHE B1101
LEU C 358
GLY A   9
VAL B1064
VAL B1095
 None
 1.13A 4jx1B-4qiwB:
undetectable		 4jx1B-4qiwB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		6 / 12 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 0.88A 4kmuC-4qiwB:
19.6		 4kmuC-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		6 / 12 GLN B 425
HIS B 438
ARG B 441
ARG B 448
PRO B 472
ASN B 476
 None
 1.32A 4kmuC-4qiwB:
19.6		 4kmuC-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ASP B 428
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 0.83A 4kmuH-4qiwB:
28.5		 4kmuH-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 GLY B 671
GLU B 470
THR B 469
 None
 0.56A 4kouA-4qiwB:
undetectable		 4kouA-4qiwB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis) 		4 / 7 VAL N  59
ILE N  56
LEU D 129
LEU D 123
 None
 1.02A 4l1wA-4qiwN:
undetectable		 4l1wA-4qiwN:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		3 / 3 ASP A 851
VAL A 854
ASN C 364
 None
 0.65A 4lmnA-4qiwA:
undetectable		 4lmnA-4qiwA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 4lvcA-4qiwB:
undetectable		 4lvcA-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.29A 4lvcB-4qiwB:
undetectable		 4lvcB-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.28A 4lvcC-4qiwB:
undetectable		 4lvcC-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL B 991
VAL B 705
ALA B 937
SER B 938
LEU B 939
 None
 1.18A 4m11C-4qiwB:
undetectable		 4m11C-4qiwB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 9 ALA B 324
GLY B 213
ILE B 214
ILE B 243
VAL B 247
 None
 1.11A 4nptA-4qiwB:
undetectable		 4nptA-4qiwB:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B 354
LEU B 355
GLY B 352
VAL B 167
ILE B 489
 None
 1.30A 4oktA-4qiwB:
undetectable		 4oktA-4qiwB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		4 / 6 MET B1035
ILE C 101
ILE C 102
VAL C 105
 None
 0.90A 4olmA-4qiwB:
undetectable		 4olmA-4qiwB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ILE B 649
GLY B 460
VAL A 787
HIS A 790
 None
 1.07A 4oltB-4qiwB:
undetectable		 4oltB-4qiwB:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.31A 4pfjA-4qiwB:
undetectable		 4pfjA-4qiwB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.29A 4pgfA-4qiwB:
undetectable		 4pgfA-4qiwB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 10 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 0.95A 4ph9A-4qiwB:
undetectable		 4ph9A-4qiwB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 10 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 0.95A 4ph9B-4qiwB:
0.1		 4ph9B-4qiwB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 THR A 835
ALA A 832
LEU A 828
THR A 831
 None
 0.89A 4pwjB-4qiwA:
undetectable		 4pwjB-4qiwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 569
THR A 657
TYR A 626
LEU A 633
LEU A 616
 None
 1.46A 4qztC-4qiwA:
undetectable		 4qztC-4qiwA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 9 THR A 667
GLU B 972
LEU B 928
VAL B 991
ILE B 992
 None
 1.28A 4r38C-4qiwA:
undetectable		 4r38C-4qiwA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		4 / 5 GLU C  30
GLU C  33
TYR C  35
GLU C  41
 None
 1.13A 4r87E-4qiwC:
undetectable		 4r87E-4qiwC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis) 		4 / 4 ASN B  96
VAL B 690
THR B 857
ILE P  34
 None
 1.40A 4retA-4qiwB:
undetectable		 4retA-4qiwB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P
(Thermococcus
kodakarensis) 		4 / 4 ASN B  96
VAL B 690
THR B 857
ILE P  34
 None
 1.39A 4retC-4qiwB:
undetectable		 4retC-4qiwB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		5 / 12 LEU F  66
ILE F 112
ILE F  73
ILE F  95
PHE F  96
 None
 1.19A 4rp8C-4qiwF:
undetectable		 4rp8C-4qiwF:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 GLU D 188
SER D 162
VAL D 165
TRP D 168
 None
 1.24A 4v3yA-4qiwD:
undetectable
4v3yB-4qiwD:
undetectable		 4v3yA-4qiwD:
20.75
4v3yB-4qiwD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 11 ALA A 646
TYR A 641
LEU A 633
ARG A 896
LEU A 567
 None
 1.03A 4wg0K-4qiwA:
undetectable
4wg0L-4qiwA:
undetectable
4wg0M-4qiwA:
undetectable		 4wg0K-4qiwA:
2.06
4wg0L-4qiwA:
2.06
4wg0M-4qiwA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 LYS B 340
ARG B 335
VAL B 327
 None
 1.04A 4x3uA-4qiwB:
undetectable
4x3uB-4qiwB:
undetectable		 4x3uA-4qiwB:
4.90
4x3uB-4qiwB:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 10 ASP A 420
HIS A 438
VAL A 440
VAL A 343
LEU A 469
 None
 1.28A 4yhaB-4qiwA:
undetectable		 4yhaB-4qiwA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		3 / 3 ARG A 861
ASP A 857
TYR H  33
 None
 0.96A 4yo9B-4qiwA:
undetectable		 4yo9B-4qiwA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 LEU B 729
ASN B 915
PRO B 916
ARG A 516
 None
 1.41A 4yv5B-4qiwB:
undetectable		 4yv5B-4qiwB:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 LYS B 956
ARG B 958
HIS B 968
 None
 1.20A 4zbrA-4qiwB:
undetectable		 4zbrA-4qiwB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 332
HIS A 507
ILE A 501
VAL A 487
 None
 1.01A 4zj8A-4qiwA:
5.1		 4zj8A-4qiwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.29A 5axaA-4qiwB:
undetectable		 5axaA-4qiwB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.30A 5axaC-4qiwB:
undetectable		 5axaC-4qiwB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
(Thermococcus
kodakarensis) 		4 / 6 ARG A 414
THR K  35
GLU A 357
ARG A 391
 None
 1.09A 5btcA-4qiwA:
0.9
5btcB-4qiwA:
undetectable
5btcC-4qiwA:
undetectable		 5btcA-4qiwA:
21.56
5btcB-4qiwA:
14.93
5btcC-4qiwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 12 ILE E  59
PHE E  18
ILE E  13
ILE K  20
LEU K  27
 None
 1.06A 5e72A-4qiwE:
undetectable		 5e72A-4qiwE:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 12 GLY D 149
GLU D 229
GLU B 748
SER B 746
GLY B 750
 None
 1.15A 5f9zA-4qiwD:
undetectable		 5f9zA-4qiwD:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.34A 5hm8A-4qiwB:
undetectable		 5hm8A-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.35A 5hm8B-4qiwB:
undetectable		 5hm8B-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.35A 5hm8C-4qiwB:
undetectable		 5hm8C-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.35A 5hm8D-4qiwB:
undetectable		 5hm8D-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.35A 5hm8E-4qiwB:
undetectable		 5hm8E-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.35A 5hm8F-4qiwB:
undetectable		 5hm8F-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.34A 5hm8G-4qiwB:
undetectable		 5hm8G-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.35A 5hm8H-4qiwB:
undetectable		 5hm8H-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 ARG A 101
HIS A 179
ARG A 169
 None
 1.12A 5iaoC-4qiwA:
undetectable		 5iaoC-4qiwA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		3 / 3 ARG A 101
HIS A 179
ARG A 169
 None
 1.11A 5iaoF-4qiwA:
undetectable		 5iaoF-4qiwA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 GLY B 460
THR B 461
GLY B 951
LEU B 650
 None
 0.91A 5jlcA-4qiwB:
undetectable		 5jlcA-4qiwB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 PHE B 882
ILE B 742
GLN B 722
ARG B 996
 None
 1.31A 5jm4A-4qiwB:
undetectable		 5jm4A-4qiwB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		4 / 7 ILE A 867
VAL A 868
TYR H  75
ARG H  77
 None
 1.18A 5kkzK-4qiwA:
2.8
5kkzQ-4qiwA:
undetectable		 5kkzK-4qiwA:
17.93
5kkzQ-4qiwA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 7 GLY B 887
ASP A 463
GLY B 918
ILE B 919
 None
MG  A1001 (-3.0A)
None
None
 0.69A 5kqyB-4qiwB:
undetectable		 5kqyB-4qiwB:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.28A 5m5kA-4qiwB:
undetectable		 5m5kA-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.26A 5m5kB-4qiwB:
undetectable		 5m5kB-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.31A 5m5kC-4qiwB:
undetectable		 5m5kC-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.29A 5m66A-4qiwB:
undetectable		 5m66A-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 5m66B-4qiwB:
undetectable		 5m66B-4qiwB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 8 HIS B 732
SER A 333
LEU B 878
VAL B 896
 None
 1.03A 5m8rB-4qiwB:
undetectable		 5m8rB-4qiwB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 10 TYR A 626
ILE A 637
ILE A 636
ILE A 491
ILE A 492
 None
 1.02A 5murE-4qiwA:
4.4		 5murE-4qiwA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		5 / 10 ILE F  95
ILE F  84
ILE F 115
ILE F 111
ILE F 112
 None
 1.04A 5murE-4qiwF:
undetectable		 5murE-4qiwF:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		5 / 9 ILE F 112
ALA F 108
ILE F 111
ILE F  95
LEU F  81
 None
 0.96A 5mvmA-4qiwF:
undetectable
5mvmE-4qiwF:
undetectable		 5mvmA-4qiwF:
25.62
5mvmE-4qiwF:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		5 / 10 ILE F  95
LEU F  81
ILE F 112
ALA F 108
ILE F 111
 None
 0.99A 5mvmD-4qiwF:
undetectable
5mvmE-4qiwF:
undetectable		 5mvmD-4qiwF:
25.62
5mvmE-4qiwF:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F
(Thermococcus
kodakarensis) 		4 / 7 SER F  44
LEU E  46
ALA F  17
LEU E  49
 None
 0.79A 5te8A-4qiwF:
undetectable		 5te8A-4qiwF:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
 None
 0.92A 5uacC-4qiwB:
21.4		 5uacC-4qiwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B 366
LEU B 403
GLY B 124
LEU B 105
MET B 107
 None
 1.11A 5uc1A-4qiwB:
undetectable		 5uc1A-4qiwB:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B 366
LEU B 403
GLY B 124
LEU B 105
MET B 107
 None
 1.09A 5uc1B-4qiwB:
undetectable		 5uc1B-4qiwB:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 GLN B 425
ASP B 428
HIS B 438
ARG B 441
ASN B 476
 None
 0.98A 5uh6C-4qiwB:
28.2		 5uh6C-4qiwB:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 GLN B 425
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 1.05A 5uhcC-4qiwB:
28.5		 5uhcC-4qiwB:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		6 / 12 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
ASN B 476
 None
 1.05A 5uhgC-4qiwB:
25.7		 5uhgC-4qiwB:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
(Thermococcus
kodakarensis) 		4 / 8 SER D 162
VAL D 165
TRP D 168
GLU D 188
 None
 1.21A 5uo7A-4qiwD:
undetectable
5uo7B-4qiwD:
undetectable		 5uo7A-4qiwD:
20.09
5uo7B-4qiwD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.31A 5utuF-4qiwB:
undetectable		 5utuF-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.31A 5utuH-4qiwB:
2.0		 5utuH-4qiwB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 5v96A-4qiwB:
undetectable		 5v96A-4qiwB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 5v96B-4qiwB:
undetectable		 5v96B-4qiwB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.26A 5v96C-4qiwB:
undetectable		 5v96C-4qiwB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 5v96D-4qiwB:
undetectable		 5v96D-4qiwB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 12 MET N  60
ALA D 124
GLU D  49
ILE D  59
VAL D  99
 None
 1.29A 5vlmG-4qiwN:
undetectable		 5vlmG-4qiwN:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 12 ILE C  72
ALA C  69
ALA C  68
LEU C 307
LEU A 845
 None
 0.95A 5z12B-4qiwC:
undetectable		 5z12B-4qiwC:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		5 / 12 ILE B 741
PHE A 462
VAL A 440
LEU A 469
LEU B 878
 None
 1.24A 6a7pA-4qiwB:
undetectable		 6a7pA-4qiwB:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 12 THR C 245
VAL C 118
THR C 264
LEU C 254
SER C 227
 None
 1.19A 6ak3A-4qiwC:
undetectable		 6ak3A-4qiwC:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 6aphA-4qiwB:
undetectable		 6aphA-4qiwB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
(Thermococcus
kodakarensis) 		5 / 12 VAL C 333
GLU A  20
PRO B1084
VAL B1062
PHE A  13
 None
None
ZN  B1201 ( 4.0A)
None
None
 1.10A 6becA-4qiwC:
undetectable
6becB-4qiwC:
undetectable
6becC-4qiwC:
undetectable		 6becA-4qiwC:
20.54
6becB-4qiwC:
20.54
6becC-4qiwC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 GLN B 425
ASP B 428
HIS B 438
ARG B 441
ARG B 448
 None
 1.44A 6ccvC-4qiwB:
28.0		 6ccvC-4qiwB:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
 None
 0.77A 6ccvC-4qiwB:
28.0		 6ccvC-4qiwB:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 218
GLY A  75
GLY A  45
ILE A 248
ILE A  77
 None
 0.87A 6dh3A-4qiwA:
undetectable		 6dh3A-4qiwA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 5 ARG A 391
ARG A 390
GLY A 389
ASP A 386
 None
 1.37A 6dwjB-4qiwA:
undetectable
6dwjD-4qiwA:
2.4		 6dwjB-4qiwA:
20.24
6dwjD-4qiwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
(Thermococcus
kodakarensis) 		4 / 5 LEU B1049
ARG K  11
PRO E  61
ARG B1122
 None
 1.28A 6ew0B-4qiwB:
undetectable		 6ew0B-4qiwB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
(Thermococcus
kodakarensis) 		4 / 5 LEU B1049
ARG K  11
PRO E  61
ARG B1122
 None
 1.28A 6ew0D-4qiwB:
undetectable		 6ew0D-4qiwB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
(Thermococcus
kodakarensis) 		4 / 5 LEU B1049
ARG K  11
PRO E  61
ARG B1122
 None
 1.28A 6ew0H-4qiwB:
undetectable		 6ew0H-4qiwB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
(Thermococcus
kodakarensis) 		4 / 5 LEU B1049
ARG K  11
PRO E  61
ARG B1122
 None
 1.27A 6ew0I-4qiwB:
undetectable		 6ew0I-4qiwB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N
(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		3 / 3 PHE B 724
ARG N  47
GLN B 722
 None
 0.95A 6g1pB-4qiwB:
undetectable		 6g1pB-4qiwB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.28A 6gbnA-4qiwB:
undetectable		 6gbnA-4qiwB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.28A 6gbnB-4qiwB:
undetectable		 6gbnB-4qiwB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_1
(-)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU B1073
HIS A  73
LYS B1102
ASP B1106
GLY A  75
 None
ZN  A1002 (-3.1A)
None
None
None
 1.27A 6gbnD-4qiwB:
undetectable		 6gbnD-4qiwB:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4qiw DNA-DIRECTED RNA
POLYMERASE
(Thermococcus
kodakarensis) 		4 / 8 ASP B 428
HIS B 438
GLU B 470
GLU B 473
 None
 1.18A 6mn4C-4qiwB:
undetectable		 6mn4C-4qiwB:
13.62