SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 7 ASN B 770
THR B 766
TRP B 776
GLY B 744
 None
 0.96A 1bu5A-4qj4B:
undetectable		 1bu5A-4qj4B:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 GLU B 778
VAL B 732
ILE B 840
VAL B 813
ILE B 816
 None
 0.85A 1c9hA-4qj4B:
undetectable		 1c9hA-4qj4B:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 8 VAL B 365
ASN B 414
ASN B 467
LEU B 437
 None
 0.54A 1dzmA-4qj4B:
undetectable		 1dzmA-4qj4B:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 PHE B 805
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 1.29A 2e7fA-4qj4B:
5.8		 2e7fA-4qj4B:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 PHE B 805
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 1.32A 2e7fB-4qj4B:
3.5		 2e7fB-4qj4B:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 TYR B 326
LEU B 315
SER B 696
LEU B 308
LEU B 143
 None
 1.36A 2hc4A-4qj4B:
undetectable		 2hc4A-4qj4B:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 5 LEU B 788
LEU B 791
LEU B 663
MET B 705
 None
 1.07A 2oaxF-4qj4B:
undetectable		 2oaxF-4qj4B:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		3 / 3 LEU B 453
PRO B 454
LEU B 323
 None
 0.56A 2po7B-4qj4B:
undetectable		 2po7B-4qj4B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 PHE B 805
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 1.32A 2ycjA-4qj4B:
8.1		 2ycjA-4qj4B:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 LEU B 354
LEU B 355
GLN B 352
VAL B 347
ARG B  73
 None
 1.42A 2yloA-4qj4B:
undetectable		 2yloA-4qj4B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 TYR B 326
LEU B 315
SER B 696
LEU B 308
LEU B 143
 None
 1.33A 2zlcA-4qj4B:
undetectable		 2zlcA-4qj4B:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 VAL B 106
VAL B 107
GLN B 831
ARG B  73
 None
 1.26A 3bjwF-4qj4B:
undetectable		 3bjwF-4qj4B:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 ILE B 796
ALA B 798
LEU B 738
LYS B 731
VAL B 823
 None
 1.10A 3ix9A-4qj4B:
undetectable		 3ix9A-4qj4B:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 ILE B 796
ALA B 798
LEU B 738
LYS B 731
VAL B 823
 None
 1.11A 3ix9B-4qj4B:
undetectable		 3ix9B-4qj4B:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 5 SER B 734
ARG B 223
GLY B 301
GLU B 303
 None
 1.02A 3k9fA-4qj4B:
2.5
3k9fB-4qj4B:
2.5
3k9fC-4qj4B:
undetectable		 3k9fA-4qj4B:
20.38
3k9fB-4qj4B:
20.38
3k9fC-4qj4B:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 ARG B 223
SER B 734
GLY B 301
GLU B 303
 None
 1.02A 3k9fA-4qj4B:
2.5
3k9fB-4qj4B:
2.5
3k9fD-4qj4B:
undetectable		 3k9fA-4qj4B:
20.38
3k9fB-4qj4B:
20.38
3k9fD-4qj4B:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 ARG B 646
HIS B 332
ASP B 364
TYR B 350
LEU B 354
 I3P  B 902 (-3.7A)
I3P  B 902 (-4.1A)
CA  B 901 (-2.0A)
None
None
 1.49A 3lmyA-4qj4B:
4.3		 3lmyA-4qj4B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 5 LEU B 308
ARG B 826
LEU B 811
PRO B 812
 None
 1.16A 3onnA-4qj4B:
undetectable		 3onnA-4qj4B:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 TYR B 279
GLY B 302
LEU B 300
GLU B 303
 None
 0.86A 3ps9A-4qj4B:
undetectable		 3ps9A-4qj4B:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 TYR B 157
ARG B 154
ASP B  46
ASN B  48
 None
 1.28A 3wfaA-4qj4B:
2.0
3wfaB-4qj4B:
undetectable		 3wfaA-4qj4B:
22.66
3wfaB-4qj4B:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 LEU B 354
LEU B 355
GLN B 352
VAL B 347
ARG B  73
 None
 1.38A 3zqtA-4qj4B:
undetectable		 3zqtA-4qj4B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 11 ASP B 851
GLU B 717
VAL B 718
ILE B 719
TYR B 847
 None
 1.29A 4drjA-4qj4B:
undetectable		 4drjA-4qj4B:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 8 ILE B 432
ILE B 463
LEU B 410
ILE B 396
 None
 0.92A 4dtaB-4qj4B:
undetectable		 4dtaB-4qj4B:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 GLY B 688
ASN B 146
GLU B 691
GLN B 662
 None
 1.19A 4g0vB-4qj4B:
undetectable		 4g0vB-4qj4B:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		3 / 3 LEU B 162
LYS B 159
THR B 158
 None
 0.51A 4lj0A-4qj4B:
undetectable		 4lj0A-4qj4B:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 GLU B 214
ASN B 150
GLY B 301
LEU B 300
TYR B 822
 None
 1.15A 4oadA-4qj4B:
undetectable		 4oadA-4qj4B:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 10 ASP B 851
GLU B 717
VAL B 718
ILE B 719
TYR B 847
 None
 1.41A 4qt2A-4qj4B:
undetectable		 4qt2A-4qj4B:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 LEU B 464
LEU B 315
GLY B 461
ALA B 436
LEU B 354
 None
 1.24A 4retA-4qj4B:
undetectable		 4retA-4qj4B:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 LEU B 464
LEU B 315
GLY B 461
ALA B 436
LEU B 354
 None
 1.24A 4retC-4qj4B:
undetectable		 4retC-4qj4B:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 VAL B 672
LEU B 674
GLU B 622
VAL B 689
PHE B 690
 None
 1.04A 4y0rA-4qj4B:
undetectable		 4y0rA-4qj4B:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 LEU B 389
VAL B 392
ILE B 396
ASN B 467
LEU B 593
 None
 1.34A 4yvpB-4qj4B:
6.2		 4yvpB-4qj4B:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 5 SER B 734
GLY B 301
GLU B 303
ARG B 223
 None
 1.17A 5cdqA-4qj4B:
undetectable
5cdqB-4qj4B:
undetectable
5cdqC-4qj4B:
undetectable		 5cdqA-4qj4B:
19.33
5cdqB-4qj4B:
13.83
5cdqC-4qj4B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 5 SER B 734
GLY B 301
GLU B 303
ARG B 223
 None
 1.17A 5cdqR-4qj4B:
undetectable
5cdqS-4qj4B:
undetectable
5cdqT-4qj4B:
undetectable		 5cdqR-4qj4B:
19.33
5cdqS-4qj4B:
13.83
5cdqT-4qj4B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 GLU B 778
VAL B 732
ILE B 840
VAL B 813
ILE B 816
 None
 0.82A 5hkgA-4qj4B:
undetectable		 5hkgA-4qj4B:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 11 ASP B 851
VAL B 718
ILE B 719
TYR B 847
ILE B 848
 None
 1.07A 5hw8D-4qj4B:
undetectable		 5hw8D-4qj4B:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 PRO B 836
LEU B 835
PHE B 152
LEU B 825
 None
 1.18A 5tl8A-4qj4B:
undetectable		 5tl8A-4qj4B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 7 LEU B 210
TYR B 279
GLU B 303
SER B 148
 None
 1.21A 5umwA-4qj4B:
undetectable
5umwF-4qj4B:
undetectable		 5umwA-4qj4B:
7.84
5umwF-4qj4B:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 PHE B  50
SER B 148
ASN B 150
ARG B 298
GLU B 214
 None
 1.49A 5v1tA-4qj4B:
undetectable		 5v1tA-4qj4B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 5 VAL B 747
THR B 764
LEU B 825
LEU B 811
 None
 1.00A 6bqgA-4qj4B:
undetectable		 6bqgA-4qj4B:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 LEU B 685
VAL B 823
THR B 842
VAL B 730
LEU B 791
 None
 1.05A 6djzA-4qj4B:
undetectable		 6djzA-4qj4B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 GLY B 301
LEU B 300
PHE B 737
PHE B 179
 None
 0.71A 6h7lA-4qj4B:
undetectable		 6h7lA-4qj4B:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		4 / 6 GLY B 301
LEU B 300
PHE B 737
PHE B 179
 None
 0.71A 6h7lB-4qj4B:
undetectable		 6h7lB-4qj4B:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens) 		5 / 12 ASP B 851
VAL B 718
ILE B 719
TYR B 847
ILE B 848
 None
 1.11A 6mkeB-4qj4B:
undetectable
6mkeC-4qj4B:
undetectable		 6mkeB-4qj4B:
8.25
6mkeC-4qj4B:
8.25