SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  73
VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 1.03A 1e7bA-4qjkA:
undetectable		 1e7bA-4qjkA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
None
None
SO4  A 303 ( 4.9A)
None
 1.41A 1hrkB-4qjkA:
undetectable		 1hrkB-4qjkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  19
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
None
None
COA  A 301 ( 4.9A)
None
 1.10A 2vmyB-4qjkA:
undetectable		 2vmyB-4qjkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  19
LEU A  11
VAL A   7
ALA A 107
SER A  90
GLY A 112
 None
None
None
None
COA  A 301 ( 4.9A)
None
 1.44A 2vmyA-4qjkA:
undetectable		 2vmyA-4qjkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
None
None
SO4  A 303 ( 4.9A)
None
 1.37A 3w1wA-4qjkA:
undetectable		 3w1wA-4qjkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 210
LEU A 227
ILE A 178
PRO A  12
VAL A  15
 None
None
None
SO4  A 303 ( 4.9A)
None
 1.39A 3w1wB-4qjkA:
undetectable		 3w1wB-4qjkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		5 / 7 LYS A 156
LEU A 152
THR A 159
ALA A 155
THR A 223
 None
None
COA  A 301 ( 3.8A)
None
None
 1.48A 4ik7A-4qjkA:
undetectable		 4ik7A-4qjkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 156
LEU A 152
ALA A 155
 None
 0.59A 4ikiA-4qjkA:
undetectable		 4ikiA-4qjkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4qjk PHOSPHOPANTETHEINYL
TRANSFERASE PPTT
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 210
THR A 167
LEU A 166
LEU A 207
 None
 0.72A 4z90F-4qjkA:
undetectable
4z90G-4qjkA:
undetectable
4z90H-4qjkA:
undetectable
4z90I-4qjkA:
undetectable
4z90J-4qjkA:
undetectable		 4z90F-4qjkA:
21.60
4z90G-4qjkA:
21.60
4z90H-4qjkA:
21.60
4z90I-4qjkA:
21.60
4z90J-4qjkA:
21.60