SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		5 / 12 ALA A 155
LEU A  11
PRO A  12
VAL A  15
ILE A 113
 None
 0.76A 1df7A-4qjlA:
undetectable		 1df7A-4qjlA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		5 / 9 ILE A  73
VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 0.87A 1e7bA-4qjlA:
undetectable		 1e7bA-4qjlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		4 / 6 VAL A 102
GLY A  89
ALA A  59
LEU A  63
 None
 0.78A 1e7bB-4qjlA:
undetectable		 1e7bB-4qjlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		4 / 7 LEU A  11
PRO A  81
VAL A 102
TRP A  83
 None
COA  A 301 (-3.9A)
None
None
 1.36A 2hrcA-4qjlA:
undetectable		 2hrcA-4qjlA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		5 / 10 VAL A  10
VAL A   7
VAL A 111
ILE A 225
VAL A 226
 None
 1.19A 2qboA-4qjlA:
undetectable		 2qboA-4qjlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		5 / 10 ALA A 158
PHE A 173
SER A 130
LEU A 121
THR A 159
 None
COA  A 301 (-3.2A)
None
None
COA  A 301 ( 3.3A)
 1.49A 4eilB-4qjlA:
undetectable		 4eilB-4qjlA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		3 / 3 LYS A 156
LEU A 152
ALA A 155
 None
 0.68A 4ikiA-4qjlA:
undetectable		 4ikiA-4qjlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		5 / 12 ALA A 155
LEU A  11
PRO A  12
VAL A  15
ILE A 113
 None
 0.88A 4m2xG-4qjlA:
undetectable		 4m2xG-4qjlA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		4 / 8 LEU A 210
THR A 167
LEU A 166
LEU A 207
 None
 0.69A 4z90F-4qjlA:
undetectable
4z90G-4qjlA:
undetectable
4z90H-4qjlA:
undetectable
4z90I-4qjlA:
undetectable
4z90J-4qjlA:
undetectable		 4z90F-4qjlA:
21.43
4z90G-4qjlA:
21.43
4z90H-4qjlA:
21.43
4z90I-4qjlA:
21.43
4z90J-4qjlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4qjl PHOSPHOPANTETHEINYL
TRANSFERASE, PPTII
(Mycobacterium
ulcerans) 		5 / 11 THR A  92
VAL A  15
LEU A  11
ALA A 115
VAL A 162
 COA  A 301 (-3.6A)
None
None
None
None
 1.23A 6dryA-4qjlA:
undetectable		 6dryA-4qjlA:
21.71