SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A  72
GLU A 184
LEU A 180
GLU A 178
PRO A 120
 None
 1.34A 1cmcA-4qkfA:
undetectable
1cmcB-4qkfA:
undetectable		 1cmcA-4qkfA:
19.60
1cmcB-4qkfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 123
HIS A 177
ILE A  70
HIS A 121
 MN  A 300 (-2.9A)
MN  A 300 ( 3.5A)
None
MN  A 300 ( 3.4A)
 1.00A 1ei6C-4qkfA:
undetectable		 1ei6C-4qkfA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 168
GLY A  98
PRO A  99
 None
 0.59A 2hreD-4qkfA:
undetectable		 2hreD-4qkfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 192
ARG A 194
PRO A 120
SER A 176
 None
 1.27A 2qd3B-4qkfA:
undetectable		 2qd3B-4qkfA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 135
GLY A 162
SER A 136
LEU A 159
LEU A  40
 None
 1.11A 3e23A-4qkfA:
undetectable		 3e23A-4qkfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 111
ARG A  74
ARG A 194
 None
 1.03A 3k37A-4qkfA:
undetectable		 3k37A-4qkfA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 110
HIS A 121
ASP A 123
HIS A 177
ILE A 179
 OGA  A 301 ( 4.6A)
MN  A 300 ( 3.4A)
MN  A 300 (-2.9A)
MN  A 300 ( 3.5A)
None
 1.10A 3kcxA-4qkfA:
8.9		 3kcxA-4qkfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 107
TRP A  81
LEU A 137
LEU A  48
 None
 1.04A 4jtrA-4qkfA:
undetectable		 4jtrA-4qkfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 110
LEU A 145
ILE A 179
ILE A  70
ALA A  69
 OGA  A 301 ( 4.6A)
None
None
None
None
 1.09A 4ltwA-4qkfA:
undetectable		 4ltwA-4qkfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ARG A 191
ARG A 197
ALA A 114
ILE A 179
 None
OGA  A 301 (-3.0A)
None
None
 0.95A 6ma7A-4qkfA:
undetectable		 6ma7A-4qkfA:
13.76