SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qko PYOCIN-S2
PYOCIN-S2 IMMUNITY
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLN B 646
ALA A  37
GLN A  36
HIS A  34
TYR A  55
 None
 1.18A 2c6nA-4qkoB:
undetectable		 2c6nA-4qkoB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4qko PYOCIN-S2 IMMUNITY
PROTEIN
PYOCIN-S2
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		5 / 12 VAL B 641
ILE A  35
VAL A  38
LEU A  39
PHE A  41
 BR  B 702 ( 4.1A)
None
None
None
None
 1.11A 3w68A-4qkoB:
undetectable		 3w68A-4qkoB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4qko PYOCIN-S2
PYOCIN-S2 IMMUNITY
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 628
ASP A  19
ILE A  20
VAL A  38
PHE A  41
 None
 1.07A 4dx5B-4qkoB:
undetectable		 4dx5B-4qkoB:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		4 / 8 LEU B 577
PHE B 625
PRO B 589
GLN B 591
 None
 1.16A 4j7uD-4qkoB:
undetectable		 4j7uD-4qkoB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 586
ALA B 593
ILE B 588
LEU B 621
GLN B 624
 None
 1.06A 4r38A-4qkoB:
undetectable		 4r38A-4qkoB:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 586
ALA B 593
ILE B 588
LEU B 621
GLN B 624
 None
 1.09A 4r38C-4qkoB:
undetectable		 4r38C-4qkoB:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 586
ALA B 593
ILE B 588
LEU B 621
GLN B 624
 None
 1.08A 4r38D-4qkoB:
undetectable		 4r38D-4qkoB:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		5 / 12 ALA B 586
ALA B 593
ILE B 588
LEU B 621
GLN B 624
 None
 1.17A 4r3aA-4qkoB:
undetectable		 4r3aA-4qkoB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4qko PYOCIN-S2
PYOCIN-S2 IMMUNITY
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 628
ASP A  19
ILE A  20
VAL A  38
PHE A  41
 None
 1.07A 4u8vB-4qkoB:
undetectable		 4u8vB-4qkoB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4qko PYOCIN-S2
PYOCIN-S2 IMMUNITY
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 628
ASP A  19
ILE A  20
VAL A  38
PHE A  41
 None
 1.07A 4u8yB-4qkoB:
undetectable		 4u8yB-4qkoB:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4qko PYOCIN-S2
PYOCIN-S2 IMMUNITY
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 628
ASP A  19
ILE A  20
VAL A  38
PHE A  41
 None
 1.09A 4u95B-4qkoB:
undetectable		 4u95B-4qkoB:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4qko PYOCIN-S2 IMMUNITY
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 PHE A  41
ASP A  52
TYR A  55
SER A  51
GLY A  50
 None
 1.26A 4xp1A-4qkoA:
undetectable		 4xp1A-4qkoA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4qko PYOCIN-S2 IMMUNITY
PROTEIN
PYOCIN-S2
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		3 / 3 ARG A  61
PRO A  57
ASN B 626
 None
 1.03A 5jwaA-4qkoA:
undetectable
5jwaH-4qkoA:
undetectable		 5jwaA-4qkoA:
11.90
5jwaH-4qkoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		4 / 8 ILE B 588
TRP B 612
VAL B 615
ASP B 594
 None
 1.16A 5vlmF-4qkoB:
undetectable		 5vlmF-4qkoB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4qko PYOCIN-S2
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 680
GLY B 583
GLU B 584
 None
 0.54A 6fgdA-4qkoB:
undetectable		 6fgdA-4qkoB:
16.03