SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4qks DE NOVO PROTEIN
6XTRP/PV2
(synthetic
construct) 		5 / 10 ILE A 130
TRP A 132
LEU A  23
ASP A 118
GLY A 119
 None
None
None
None
SO4  A 201 (-4.8A)
 1.39A 6r2eB-4qksA:
undetectable		 6r2eB-4qksA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4qks DE NOVO PROTEIN
6XTRP/PV2
(synthetic
construct) 		5 / 10 ILE A 130
TRP A 132
LEU A  23
ASP A 118
GLY A 119
 None
None
None
None
SO4  A 201 (-4.8A)
 1.48A 6r2eC-4qksA:
undetectable		 6r2eC-4qksA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4qks DE NOVO PROTEIN
6XTRP/PV2
(synthetic
construct) 		5 / 10 ILE A 130
TRP A 132
LEU A  23
ASP A 118
GLY A 119
 None
None
None
None
SO4  A 201 (-4.8A)
 1.48A 6r2eD-4qksA:
undetectable		 6r2eD-4qksA:
19.94