SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 221
ILE A 220
PHE A 219
VAL A 181
ILE A 274
 None
 1.14A 1c9hA-4qkuA:
undetectable		 1c9hA-4qkuA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 PHE A  29
GLY A  53
TRP A 277
PHE A  36
 None
 0.85A 1fapB-4qkuA:
undetectable		 1fapB-4qkuA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A 312
HIS A 336
MET A 337
GLY A 362
LEU A 215
 None
 1.06A 2azyA-4qkuA:
undetectable		 2azyA-4qkuA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A 246
LEU A 360
PRO A 133
VAL A 134
 None
 1.12A 2dqyC-4qkuA:
undetectable		 2dqyC-4qkuA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 ASP A 248
LYS A 268
GLY A 362
GLU A 216
 NA  A 501 (-3.4A)
SO4  A 503 ( 2.6A)
None
None
 1.03A 2ys6A-4qkuA:
undetectable		 2ys6A-4qkuA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 ASP A 248
LYS A 268
GLY A 364
GLU A 216
 NA  A 501 (-3.4A)
SO4  A 503 ( 2.6A)
None
None
 0.89A 2ys6A-4qkuA:
undetectable		 2ys6A-4qkuA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 421
GLY A 409
ARG A 417
LEU A 407
GLU A 315
 None
 1.15A 3ckkA-4qkuA:
undetectable		 3ckkA-4qkuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 6 VAL A 134
LEU A  82
ILE A  86
VAL A 244
 None
 0.93A 4a9kA-4qkuA:
undetectable		 4a9kA-4qkuA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 408
LEU A 380
VAL A 388
ILE A 213
THR A 422
 None
 1.13A 4km2A-4qkuA:
undetectable		 4km2A-4qkuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A 358
THR A  81
LEU A 132
ASN A  83
 None
 1.17A 4m5mA-4qkuA:
undetectable		 4m5mA-4qkuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A  57
PHE A  36
ARG A  97
 None
 0.94A 4xr4B-4qkuA:
undetectable		 4xr4B-4qkuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A  77
LEU A 100
GLY A  49
VAL A  57
VAL A  50
 None
 1.35A 4yb6D-4qkuA:
undetectable
4yb6E-4qkuA:
undetectable		 4yb6D-4qkuA:
21.94
4yb6E-4qkuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 PHE A  29
GLY A  53
TRP A 277
PHE A  36
 None
 0.91A 5flcB-4qkuA:
undetectable		 5flcB-4qkuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 PHE A  29
GLY A  53
TRP A 277
PHE A  36
 None
 0.91A 5flcF-4qkuA:
undetectable		 5flcF-4qkuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 221
ILE A 220
PHE A 219
VAL A 181
ILE A 274
 None
 1.16A 5hkgA-4qkuA:
undetectable		 5hkgA-4qkuA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 134
ARG A  97
PRO A  48
GLY A  49
LEU A  59
 None
 1.26A 5ogcB-4qkuA:
undetectable		 5ogcB-4qkuA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
 None
 0.99A 6ebzA-4qkuA:
undetectable		 6ebzA-4qkuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
 None
 1.00A 6ebzB-4qkuA:
undetectable		 6ebzB-4qkuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
 None
 1.03A 6ebzC-4qkuA:
undetectable		 6ebzC-4qkuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
 None
 0.98A 6ebzD-4qkuA:
undetectable		 6ebzD-4qkuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
 None
 0.99A 6gp2A-4qkuA:
undetectable		 6gp2A-4qkuA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4qku HYDROLASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
 None
 1.07A 6gp2B-4qkuA:
undetectable		 6gp2B-4qkuA:
10.66