SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ql6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 11 VAL A  38
ILE A 221
ALA A 225
SER A 227
LEU A 228
 None
 1.00A 1eqgB-4ql6A:
undetectable		 1eqgB-4ql6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 12 ILE A 220
LEU A 103
PHE A 100
LEU A  88
PRO A  87
 None
 0.78A 1jolB-4ql6A:
undetectable		 1jolB-4ql6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 5 SER A 223
SER A 227
PHE A 100
VAL A  34
 None
 1.28A 1oipA-4ql6A:
3.1		 1oipA-4ql6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 12 ILE A 220
LEU A 103
PHE A 100
LEU A  88
PRO A  87
 None
 0.89A 1rx8A-4ql6A:
undetectable		 1rx8A-4ql6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 6 ASP A 394
LEU A 448
VAL A 447
ILE A 472
 None
 0.91A 1s9qA-4ql6A:
undetectable		 1s9qA-4ql6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 12 ILE A 220
LEU A 103
PHE A 100
LEU A  88
PRO A  87
 None
 0.92A 2d0kA-4ql6A:
undetectable		 2d0kA-4ql6A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 7 LEU A  37
ILE A  51
ARG A  54
SER A  55
 None
 0.94A 2hc4A-4ql6A:
undetectable		 2hc4A-4ql6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 11 GLU A 238
TYR A 234
THR A  33
VAL A 218
ASN A 214
 None
 1.22A 2z9wA-4ql6A:
undetectable		 2z9wA-4ql6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 11 GLU A 238
TYR A 234
THR A  33
VAL A 218
ASN A 214
 None
 1.25A 2z9wB-4ql6A:
undetectable		 2z9wB-4ql6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 5 GLN A 477
THR A 478
THR A 483
HIS A 231
 None
 1.26A 2zj0B-4ql6A:
undetectable		 2zj0B-4ql6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 5 GLN A 477
THR A 478
THR A 483
HIS A 231
 None
 1.31A 2zj0C-4ql6A:
undetectable		 2zj0C-4ql6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 7 LEU A 403
LEU A 559
VAL A 429
LEU A 575
 None
 0.89A 3g8iA-4ql6A:
undetectable		 3g8iA-4ql6A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 11 LEU A 471
ASP A 394
GLY A 356
ILE A 355
PRO A 444
 None
 1.12A 3spkA-4ql6A:
undetectable		 3spkA-4ql6A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 6 GLY A 474
ILE A 525
GLN A 626
SER A 630
 None
 1.04A 4d39B-4ql6A:
undetectable		 4d39B-4ql6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		3 / 3 TYR A 541
PHE A  80
ARG A  61
 None
 0.98A 4g19D-4ql6A:
undetectable		 4g19D-4ql6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 6 ASN A 398
ALA A 454
TYR A 479
ASP A 475
 None
 0.87A 4mdaA-4ql6A:
undetectable		 4mdaA-4ql6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 9 LEU A 360
GLY A 400
VAL A 449
ILE A 459
ILE A 395
 None
 0.89A 4rvjB-4ql6A:
undetectable		 4rvjB-4ql6A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 9 LEU A 360
GLY A 400
VAL A 449
ILE A 459
ILE A 395
 None
 0.90A 4rvjD-4ql6A:
undetectable		 4rvjD-4ql6A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 7 LEU A  70
SER A  77
THR A  85
VAL A  60
 None
 1.04A 4wnvD-4ql6A:
undetectable		 4wnvD-4ql6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		5 / 12 ILE A 220
LEU A 103
PHE A 100
LEU A  88
PRO A  87
 None
 0.76A 5eajB-4ql6A:
undetectable		 5eajB-4ql6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 6 ASP A  58
HIS A 226
ILE A 224
TYR A 197
 None
 1.10A 5ih0A-4ql6A:
undetectable		 5ih0A-4ql6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 8 THR A 359
SER A 453
ASP A 475
SER A 527
 None
 1.10A 5l5fY-4ql6A:
undetectable
5l5fZ-4ql6A:
undetectable		 5l5fY-4ql6A:
17.14
5l5fZ-4ql6A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		3 / 3 LEU A 228
VAL A  34
ASP A  35
 None
 0.58A 5x23A-4ql6A:
undetectable		 5x23A-4ql6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE
(Chlamydia
trachomatis) 		4 / 7 ASP A 466
GLN A 465
SER A 510
GLY A 511
 None
 0.94A 6ekzA-4ql6A:
undetectable		 6ekzA-4ql6A:
8.95