SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 11 ALA A 237
LEU A 168
LEU A 151
GLY A 225
ALA A 183
 None
 0.98A 1b02A-4qlaA:
undetectable		 1b02A-4qlaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 8 SER A 157
HIS A 131
SER A 185
HIS A 152
 None
 1.14A 1eqbA-4qlaA:
undetectable
1eqbB-4qlaA:
2.0		 1eqbA-4qlaA:
21.97
1eqbB-4qlaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 8 SER A 157
HIS A 131
SER A 185
HIS A 152
 None
 1.15A 1eqbA-4qlaA:
undetectable
1eqbB-4qlaA:
2.0		 1eqbA-4qlaA:
21.97
1eqbB-4qlaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 8 SER A 157
HIS A 131
SER A 185
HIS A 152
 None
 1.15A 1eqbC-4qlaA:
undetectable
1eqbD-4qlaA:
undetectable		 1eqbC-4qlaA:
21.97
1eqbD-4qlaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 8 SER A 157
HIS A 131
SER A 185
HIS A 152
 None
 1.16A 1eqbC-4qlaA:
undetectable
1eqbD-4qlaA:
undetectable		 1eqbC-4qlaA:
21.97
1eqbD-4qlaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 LEU A  67
LEU A  99
ARG A  74
MET A 358
ILE A 354
 None
 1.15A 1g50B-4qlaA:
undetectable		 1g50B-4qlaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 11 LEU A  67
LEU A  99
ARG A  74
MET A 358
ILE A 354
 None
 1.15A 1g50C-4qlaA:
undetectable		 1g50C-4qlaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		3 / 3 ALA A 203
VAL A 205
TRP A  39
 None
 0.91A 1grmA-4qlaA:
undetectable		 1grmA-4qlaA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		3 / 3 ALA A 203
VAL A 205
TRP A  39
 None
 0.91A 1grmB-4qlaA:
undetectable		 1grmB-4qlaA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 SER A 365
TYR A 360
SER A 192
PHE A 209
HIS A 152
 None
 1.26A 1q23D-4qlaA:
undetectable
1q23E-4qlaA:
undetectable		 1q23D-4qlaA:
19.36
1q23E-4qlaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 8 SER A 157
HIS A 131
SER A 185
HIS A 152
 None
 1.12A 2vmyA-4qlaA:
undetectable
2vmyB-4qlaA:
undetectable		 2vmyA-4qlaA:
23.09
2vmyB-4qlaA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 5 ARG A 347
ASP A 427
ILE A 425
GLU A 435
 None
 1.36A 2xrzA-4qlaA:
undetectable
2xrzB-4qlaA:
undetectable		 2xrzA-4qlaA:
23.99
2xrzB-4qlaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 ALA A 252
THR A 395
ASN A 250
GLY A 225
LEU A 432
 None
 1.38A 3aodC-4qlaA:
undetectable		 3aodC-4qlaA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 GLY A 156
GLY A 226
GLY A 153
LEU A 398
VAL A 444
 None
 1.01A 3gczA-4qlaA:
undetectable		 3gczA-4qlaA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 LEU A 386
SER A 234
ILE A 389
PHE A 247
SER A 249
 None
 1.39A 3ko0G-4qlaA:
undetectable
3ko0H-4qlaA:
undetectable
3ko0I-4qlaA:
undetectable
3ko0J-4qlaA:
undetectable		 3ko0G-4qlaA:
12.02
3ko0H-4qlaA:
12.02
3ko0I-4qlaA:
12.02
3ko0J-4qlaA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 GLY A 226
HIS A 152
LEU A 398
MET A 251
ASP A 443
 None
 1.39A 3pfgA-4qlaA:
undetectable		 3pfgA-4qlaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 GLY A 188
GLY A 190
LEU A 149
VAL A 205
ALA A 206
 None
 1.14A 3t7vA-4qlaA:
undetectable		 3t7vA-4qlaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 9 LEU A 386
ALA A 203
LEU A  33
PHE A 239
THR A 238
 None
 1.22A 4ltwA-4qlaA:
undetectable		 4ltwA-4qlaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 10 GLY A 319
ILE A 366
LEU A 320
LEU A 313
TYR A 360
 None
 1.03A 4xj7A-4qlaA:
3.2
4xj7B-4qlaA:
3.5		 4xj7A-4qlaA:
22.29
4xj7B-4qlaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		4 / 5 ASN A 250
GLY A 246
HIS A 248
ASP A 443
 None
 0.92A 6gh9A-4qlaA:
undetectable		 6gh9A-4qlaA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 LEU A 168
LEU A 151
GLY A 225
ASN A 250
ALA A 183
 None
 1.20A 6r2eE-4qlaA:
undetectable		 6r2eE-4qlaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 11 LEU A 168
LEU A 151
GLY A 225
ASN A 250
ALA A 183
 None
 1.17A 6r2eF-4qlaA:
undetectable		 6r2eF-4qlaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4qla JUVENILE HORMONE
EPOXIDE HYDROLASE
(Bombyx
mori) 		5 / 12 LEU A 168
LEU A 151
GLY A 225
ASN A 250
ALA A 183
 None
 1.11A 6r2eH-4qlaA:
undetectable		 6r2eH-4qlaA:
22.48