SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qlo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 10 LEU A 140
LEU A 141
ILE A 241
HIS A 239
LEU A 105
 None
 1.39A 1a52A-4qloA:
undetectable		 1a52A-4qloA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 9 LEU A 189
LEU A 233
GLU A 169
ILE A 175
PHE A 220
 None
 1.28A 1gx8A-4qloA:
undetectable		 1gx8A-4qloA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 GLY A 190
SER A 164
ASP A 237
THR A 160
 None
 0.89A 1m4iA-4qloA:
undetectable		 1m4iA-4qloA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 LEU A  39
ASN A 125
GLU A 147
THR A 257
ILE A 126
 None
 1.10A 2vn0A-4qloA:
undetectable		 2vn0A-4qloA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 THR A  16
ILE A  22
ASP A 107
SER A  18
 None
 1.09A 2xytH-4qloA:
undetectable		 2xytH-4qloA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 THR A  16
ILE A  22
ASP A 107
SER A  18
 None
 1.09A 2xytI-4qloA:
undetectable		 2xytI-4qloA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 8 ILE A  65
ASN A  49
HIS A  44
GLY A 129
 None
 0.88A 3em0B-4qloA:
undetectable		 3em0B-4qloA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 PRO A  38
LEU A  39
GLN A  77
 None
 0.64A 3hznG-4qloA:
undetectable
3hznH-4qloA:
undetectable		 3hznG-4qloA:
21.37
3hznH-4qloA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 ASP A 267
TYR A 163
PRO A 271
GLN A 274
 None
 1.25A 3s3oA-4qloA:
undetectable		 3s3oA-4qloA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 4 PRO A  59
LEU A  51
HIS A  44
LEU A 132
 None
 1.27A 3vw7A-4qloA:
undetectable		 3vw7A-4qloA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ARG A 114
GLU A 113
PHE A 146
 None
 0.99A 4kszA-4qloA:
undetectable		 4kszA-4qloA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 SER A 131
MET A 135
ASP A 272
 None
 0.91A 4mm4B-4qloA:
undetectable		 4mm4B-4qloA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 7 GLY A 263
PHE A 288
ASP A 272
ASN A 293
 None
 1.04A 5n5dB-4qloA:
2.7		 5n5dB-4qloA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ARG A 276
MET A 262
THR A 261
LEU A 260
 None
 1.35A 5x19J-4qloA:
undetectable		 5x19J-4qloA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 ARG A 276
MET A 262
THR A 261
LEU A 260
 None
 1.31A 5x1bJ-4qloA:
undetectable		 5x1bJ-4qloA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 4 VAL A 290
GLY A 263
ASP A 272
ASP A 267
 None
 1.11A 6cjkC-4qloA:
undetectable		 6cjkC-4qloA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 4qlo HOMOSERINE
O-ACETYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 HIS A 296
SER A 161
THR A 160
TYR A 163
PHE A 167
 None
 1.41A 6d6tD-4qloA:
undetectable
6d6tE-4qloA:
undetectable		 6d6tD-4qloA:
23.57
6d6tE-4qloA:
19.72