SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qlr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		6 / 12 LEU A   4
ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
 None
 0.64A 3qxtB-4qlrA:
22.9		 3qxtB-4qlrA:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		6 / 12 VAL A   2
LEU A   4
ALA A  24
ARG A  72
ALA A  98
TYR A 113
 None
 0.87A 3qxtB-4qlrA:
22.9		 3qxtB-4qlrA:
70.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		6 / 12 ALA A  24
ARG A  72
ASN A  74
VAL A  79
ALA A  98
TYR A 113
 None
 0.73A 3qxvA-4qlrA:
22.2		 3qxvA-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
 None
 0.78A 3qxvB-4qlrA:
22.3		 3qxvB-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		5 / 11 ALA A  24
ARG A  72
ASN A  74
VAL A  79
ALA A  98
 None
 0.76A 3qxvC-4qlrA:
22.5		 3qxvC-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
 None
 0.76A 3qxvD-4qlrA:
22.4		 3qxvD-4qlrA:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		5 / 12 ALA A  24
ARG A  72
VAL A  79
ALA A  98
TYR A 113
 None
 0.83A 3qxvE-4qlrA:
18.6		 3qxvE-4qlrA:
69.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		4 / 7 ALA A  92
THR A  91
VAL A 120
GLU A  89
 None
 0.73A 5ecmD-4qlrA:
undetectable		 5ecmD-4qlrA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4qlr LLAMA NANOBODY N02
VH DOMAIN
(Lama
glama) 		4 / 7 ALA A  92
THR A  91
VAL A 120
GLU A  89
 None
 0.83A 5ecoD-4qlrA:
1.3		 5ecoD-4qlrA:
12.50