SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 5 LEU A  17
PRO A  31
VAL A  30
ILE A  24
 None
 0.80A 2aoiB-4qlzA:
undetectable		 2aoiB-4qlzA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		3 / 3 LYS A 191
ASP A 105
ASP A 145
 None
None
CO  A 404 (-3.2A)
 0.83A 2br4D-4qlzA:
undetectable		 2br4D-4qlzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		3 / 3 ALA A 259
THR A 243
PHE A  16
 None
 0.76A 2c6nB-4qlzA:
undetectable		 2c6nB-4qlzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 8 LYS A 152
TYR A  91
PRO A  65
PHE A  16
 CO  A 404 ( 3.2A)
PO4  A 405 (-4.6A)
None
None
 1.27A 3bjwD-4qlzA:
undetectable		 3bjwD-4qlzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
 None
 0.78A 3cywA-4qlzA:
undetectable		 3cywA-4qlzA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		3 / 3 TYR A  26
TYR A  13
GLY A 130
 None
 0.58A 3eteB-4qlzA:
undetectable
3eteD-4qlzA:
undetectable
3eteF-4qlzA:
undetectable		 3eteB-4qlzA:
20.98
3eteD-4qlzA:
20.98
3eteF-4qlzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
 None
 0.74A 3lzsA-4qlzA:
undetectable		 3lzsA-4qlzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
 None
 0.80A 3lzuA-4qlzA:
undetectable		 3lzuA-4qlzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
 None
 0.70A 3nduA-4qlzA:
undetectable		 3nduA-4qlzA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 9 LEU A  32
ILE A 169
ILE A 122
MET A  43
ILE A 156
 None
 1.22A 3zosB-4qlzA:
undetectable		 3zosB-4qlzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 8 ASN A  64
GLU A  56
ILE A  57
ASP A 115
 None
CO  A 403 (-3.4A)
None
CO  A 403 ( 3.5A)
 0.97A 4d33A-4qlzA:
undetectable		 4d33A-4qlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 7 ASN A  64
GLU A  56
ILE A  57
ASP A 115
 None
CO  A 403 (-3.4A)
None
CO  A 403 ( 3.5A)
 0.96A 4d33B-4qlzA:
undetectable		 4d33B-4qlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 8 ASN A  64
GLU A  56
ILE A  57
ASP A 115
 None
CO  A 403 (-3.4A)
None
CO  A 403 ( 3.5A)
 0.99A 4d39A-4qlzA:
undetectable		 4d39A-4qlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 7 ASN A  64
GLU A  56
ILE A  57
ASP A 115
 None
CO  A 403 (-3.4A)
None
CO  A 403 ( 3.5A)
 0.99A 4d39B-4qlzA:
undetectable		 4d39B-4qlzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 8 ASP A 118
GLU A  60
ASP A 113
GLU A 148
 CO  A 401 (-2.5A)
None
CO  A 401 ( 2.8A)
None
 1.10A 4feuD-4qlzA:
undetectable		 4feuD-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 7 ASP A 118
ASN A 114
GLU A  60
GLU A 148
 CO  A 401 (-2.5A)
None
None
None
 1.22A 4fevB-4qlzA:
undetectable		 4fevB-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 7 ASP A 118
GLU A  60
ASP A 113
GLU A 148
 CO  A 401 (-2.5A)
None
CO  A 401 ( 2.8A)
None
 1.18A 4fevB-4qlzA:
undetectable		 4fevB-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 7 ASP A 118
GLU A  60
ASP A 113
GLU A 148
 CO  A 401 (-2.5A)
None
CO  A 401 ( 2.8A)
None
 1.21A 4fewB-4qlzA:
undetectable		 4fewB-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 8 ASP A 118
GLU A  60
ASP A 113
GLU A 148
 CO  A 401 (-2.5A)
None
CO  A 401 ( 2.8A)
None
 1.16A 4gkhD-4qlzA:
undetectable		 4gkhD-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 8 ASP A  69
ASP A 150
GLU A  56
GLU A 148
 None
CO  A 404 (-2.8A)
CO  A 403 (-3.4A)
None
 1.12A 4gkhC-4qlzA:
undetectable
4gkhK-4qlzA:
undetectable		 4gkhC-4qlzA:
20.07
4gkhK-4qlzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 11 ILE A 122
ILE A  88
ILE A 154
ALA A 182
VAL A 172
 None
 0.99A 4h1nA-4qlzA:
undetectable		 4h1nA-4qlzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
 None
 0.78A 4hlaA-4qlzA:
undetectable		 4hlaA-4qlzA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 11 LEU A  17
GLY A  20
PRO A  31
VAL A  30
ILE A  24
 None
 0.78A 4hlaB-4qlzA:
undetectable		 4hlaB-4qlzA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 PRO A 236
LEU A 227
LYS A 226
VAL A 251
PRO A 248
 None
 1.35A 4idkA-4qlzA:
undetectable		 4idkA-4qlzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 9 VAL A 158
ILE A 117
VAL A 119
ALA A  93
VAL A 132
 None
 1.31A 4oqrA-4qlzA:
undetectable		 4oqrA-4qlzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		5 / 12 GLU A  60
ILE A  57
ASP A 118
ALA A  93
SER A  25
 None
None
CO  A 401 (-2.5A)
None
None
 1.27A 4uroC-4qlzA:
undetectable		 4uroC-4qlzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4qlz SJCHGC07024 PROTEIN
(Schistosoma
japonicum) 		4 / 6 ILE A 126
PRO A  48
HIS A  68
ILE A 277
 None
 1.01A 4zj8A-4qlzA:
undetectable		 4zj8A-4qlzA:
18.27