SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qmd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		4 / 6 SER A1916
VAL A1917
GLY A1918
LEU A1935
 None
 1.01A 1fduD-4qmdA:
undetectable		 1fduD-4qmdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		5 / 11 SER A1916
VAL A1917
GLY A1918
LEU A1935
GLY A1905
 None
 1.29A 1iolA-4qmdA:
undetectable		 1iolA-4qmdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		3 / 3 ASP A1851
LEU A1850
HIS A1934
 None
 0.72A 1qknA-4qmdA:
undetectable		 1qknA-4qmdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		3 / 3 SER A1987
GLU A1995
ASP A1981
 None
 0.80A 2avdB-4qmdA:
undetectable		 2avdB-4qmdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		4 / 6 PRO A1985
LEU A1858
ALA A1996
PRO A2012
 None
 1.32A 3gv1A-4qmdA:
undetectable
3gv1C-4qmdA:
undetectable		 3gv1A-4qmdA:
20.73
3gv1C-4qmdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		4 / 6 LEU A1858
ALA A1996
PRO A2012
PRO A1985
 None
 1.33A 3gv1A-4qmdA:
undetectable
3gv1B-4qmdA:
undetectable		 3gv1A-4qmdA:
20.73
3gv1B-4qmdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4qmd ENVOPLAKIN
(Homo
sapiens) 		5 / 10 LEU A2011
ILE A1827
GLY A1855
LEU A1991
ALA A1996
 None
 0.99A 5o96C-4qmdA:
undetectable
5o96D-4qmdA:
undetectable		 5o96C-4qmdA:
21.77
5o96D-4qmdA:
21.77