SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 GLU A 339
THR A 677
ALA A 609
LEU A 611
 None
 0.89A 1etb2-4qmeA:
undetectable		 1etb2-4qmeA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 ALA A 609
SER A 665
ARG A 336
LEU A 610
 None
 1.23A 1gahA-4qmeA:
undetectable		 1gahA-4qmeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.68A 1j36A-4qmeA:
6.6		 1j36A-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.68A 1j36B-4qmeA:
6.6		 1j36B-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.66A 1j37A-4qmeA:
7.4		 1j37A-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.67A 1j37B-4qmeA:
3.9		 1j37B-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 211
ASN A 265
GLY A 286
ALA A 222
VAL A 219
 None
 1.11A 1jg4A-4qmeA:
undetectable		 1jg4A-4qmeA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 VAL A 249
ASN A 265
GLY A 286
ALA A 222
VAL A 219
 None
 0.94A 1jg4A-4qmeA:
undetectable		 1jg4A-4qmeA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 LEU A 774
LEU A 783
ILE A 805
GLU A 811
 None
 1.10A 1mt1A-4qmeA:
undetectable
1mt1F-4qmeA:
undetectable		 1mt1A-4qmeA:
8.61
1mt1F-4qmeA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.66A 1o86A-4qmeA:
7.5		 1o86A-4qmeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 GLY A  53
ASP A  52
ILE A 128
TYR A  16
ALA A  15
 None
 1.27A 1oltA-4qmeA:
undetectable		 1oltA-4qmeA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 PHE A 827
ALA A 844
ARG A 803
ASP A 798
 None
 1.00A 2bxkA-4qmeA:
undetectable		 2bxkA-4qmeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		6 / 12 ALA A 258
HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 (-3.8A)
37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.63A 2c6nA-4qmeA:
4.3		 2c6nA-4qmeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.69A 2c6nB-4qmeA:
undetectable		 2c6nB-4qmeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ARG A 636
SER A 616
GLN A 564
GLU A 619
 SO4  A 913 (-3.0A)
None
None
None
 1.07A 2c8aA-4qmeA:
undetectable		 2c8aA-4qmeA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.17A 2f16H-4qmeA:
undetectable
2f16I-4qmeA:
undetectable		 2f16H-4qmeA:
13.31
2f16I-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.18A 2f16V-4qmeA:
undetectable
2f16W-4qmeA:
undetectable		 2f16V-4qmeA:
13.31
2f16W-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 0.97A 2f80A-4qmeA:
undetectable		 2f80A-4qmeA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 THR A 709
ARG A 676
ASP A 275
ASP A 215
 None
 1.09A 2okcA-4qmeA:
undetectable		 2okcA-4qmeA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 THR A 709
ARG A 676
ASP A 275
ASP A 215
 None
 1.06A 2okcB-4qmeA:
undetectable		 2okcB-4qmeA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 9 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 1.08A 2r5qA-4qmeA:
undetectable		 2r5qA-4qmeA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 9 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 1.08A 2r5qC-4qmeA:
undetectable		 2r5qC-4qmeA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A 483
LEU A 548
GLY A 488
PHE A 455
LEU A 450
 None
 1.41A 2w8yA-4qmeA:
undetectable		 2w8yA-4qmeA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.59A 2x8zA-4qmeA:
8.4		 2x8zA-4qmeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.62A 2x91A-4qmeA:
4.8		 2x91A-4qmeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ILE A 338
LEU A 610
PHE A 607
THR A 565
 None
None
None
SO4  A 917 (-4.1A)
 1.05A 2zxwN-4qmeA:
3.4
2zxwW-4qmeA:
undetectable		 2zxwN-4qmeA:
19.71
2zxwW-4qmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 GLU A 316
HIS A 293
HIS A 297
GLU A 294
 ZN  A 908 ( 2.0A)
37B  A 901 ( 3.2A)
ZN  A 908 ( 3.2A)
37B  A 901 (-2.6A)
 0.85A 3a6jB-4qmeA:
undetectable		 3a6jB-4qmeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 GLU A 316
HIS A 293
HIS A 297
GLU A 294
 ZN  A 908 ( 2.0A)
37B  A 901 ( 3.2A)
ZN  A 908 ( 3.2A)
37B  A 901 (-2.6A)
 0.85A 3a6jC-4qmeA:
undetectable		 3a6jC-4qmeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 GLU A 316
HIS A 293
HIS A 297
GLU A 294
 ZN  A 908 ( 2.0A)
37B  A 901 ( 3.2A)
ZN  A 908 ( 3.2A)
37B  A 901 (-2.6A)
 0.85A 3a6jF-4qmeA:
undetectable		 3a6jF-4qmeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ILE A 338
LEU A 610
PHE A 607
THR A 565
 None
None
None
SO4  A 917 (-4.1A)
 1.03A 3ag2N-4qmeA:
2.3
3ag2W-4qmeA:
undetectable		 3ag2N-4qmeA:
19.71
3ag2W-4qmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ILE A 338
LEU A 610
PHE A 607
THR A 565
 None
None
None
SO4  A 917 (-4.1A)
 1.02A 3ag4N-4qmeA:
undetectable
3ag4W-4qmeA:
undetectable		 3ag4N-4qmeA:
19.71
3ag4W-4qmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 ALA A  55
GLY A 104
ASP A  52
VAL A  60
LEU A  57
 None
 1.04A 3m6wA-4qmeA:
undetectable		 3m6wA-4qmeA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.21A 3mg0H-4qmeA:
undetectable
3mg0I-4qmeA:
2.2		 3mg0H-4qmeA:
13.31
3mg0I-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 TYR A 747
ASN A 719
LEU A 730
TRP A 712
 None
 1.23A 3nk2X-4qmeA:
undetectable		 3nk2X-4qmeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A 833
ALA A 796
GLY A 801
LEU A 630
HIS A 836
 None
 1.10A 3ou6B-4qmeA:
undetectable		 3ou6B-4qmeA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A 833
ALA A 796
GLY A 801
LEU A 630
HIS A 836
 None
 1.12A 3ou7B-4qmeA:
undetectable		 3ou7B-4qmeA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 10 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 0.99A 3oxwD-4qmeA:
undetectable		 3oxwD-4qmeA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ASP A 745
VAL A 819
ILE A 812
SER A 782
 None
 0.96A 3pglA-4qmeA:
undetectable		 3pglA-4qmeA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 GLY A 395
GLY A 426
ALA A 424
ALA A 420
ALA A 419
 None
 1.02A 3sudA-4qmeA:
undetectable		 3sudA-4qmeA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 GLY A 395
GLY A 426
ALA A 424
ALA A 420
ALA A 419
 None
 1.01A 3sudD-4qmeA:
undetectable		 3sudD-4qmeA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 ASP A 281
GLY A 674
TYR A 668
GLU A 285
 None
 1.16A 3w9tA-4qmeA:
undetectable		 3w9tA-4qmeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 ASP A 281
GLY A 674
TYR A 668
GLU A 285
 None
 1.16A 3w9tB-4qmeA:
undetectable		 3w9tB-4qmeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 ASP A 281
GLY A 674
TYR A 668
GLU A 285
 None
 1.17A 3w9tC-4qmeA:
undetectable		 3w9tC-4qmeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 ASP A 281
GLY A 674
TYR A 668
GLU A 285
 None
 1.17A 3w9tD-4qmeA:
undetectable		 3w9tD-4qmeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 ASP A 281
GLY A 674
TYR A 668
GLU A 285
 None
 1.16A 3w9tF-4qmeA:
undetectable		 3w9tF-4qmeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 ASP A 281
GLY A 674
TYR A 668
GLU A 285
 None
 1.17A 3w9tG-4qmeA:
undetectable		 3w9tG-4qmeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.67A 4c2pA-4qmeA:
7.5		 4c2pA-4qmeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 9 GLY A 257
HIS A 293
GLU A 294
GLU A 316
TYR A 377
 37B  A 901 (-3.4A)
37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.35A 4dprA-4qmeA:
23.2		 4dprA-4qmeA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 ILE A  18
THR A  21
VAL A  50
SER A 180
 None
 1.10A 4iaqA-4qmeA:
2.7		 4iaqA-4qmeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 SER A 782
ASP A 283
ASP A 275
 None
 0.83A 4mwzA-4qmeA:
undetectable		 4mwzA-4qmeA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 LEU A 550
LEU A 566
ALA A 563
LEU A 643
LEU A 611
 None
 1.10A 4p65E-4qmeA:
undetectable
4p65F-4qmeA:
undetectable
4p65J-4qmeA:
undetectable
4p65L-4qmeA:
undetectable		 4p65E-4qmeA:
2.42
4p65F-4qmeA:
4.60
4p65J-4qmeA:
4.60
4p65L-4qmeA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 GLU A 119
THR A   4
HIS A   6
 None
 0.84A 4q15A-4qmeA:
undetectable		 4q15A-4qmeA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 0.98A 4q1yB-4qmeA:
undetectable		 4q1yB-4qmeA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.18A 4qvpH-4qmeA:
undetectable
4qvpI-4qmeA:
2.2		 4qvpH-4qmeA:
14.38
4qvpI-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.17A 4qvpV-4qmeA:
undetectable
4qvpW-4qmeA:
undetectable		 4qvpV-4qmeA:
14.38
4qvpW-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.20A 4qvyV-4qmeA:
undetectable
4qvyW-4qmeA:
undetectable		 4qvyV-4qmeA:
14.38
4qvyW-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.19A 4qw0H-4qmeA:
undetectable
4qw0I-4qmeA:
2.1		 4qw0H-4qmeA:
14.38
4qw0I-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.19A 4qw0V-4qmeA:
undetectable
4qw0W-4qmeA:
undetectable		 4qw0V-4qmeA:
14.38
4qw0W-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.21A 4qw1H-4qmeA:
undetectable
4qw1I-4qmeA:
2.2		 4qw1H-4qmeA:
14.38
4qw1I-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.20A 4qw1V-4qmeA:
undetectable
4qw1W-4qmeA:
undetectable		 4qw1V-4qmeA:
14.38
4qw1W-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 ILE A 865
GLU A 351
GLY A 354
THR A 466
 None
 0.49A 4r20A-4qmeA:
undetectable		 4r20A-4qmeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 372
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.26A 4r7lA-4qmeA:
22.4		 4r7lA-4qmeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		6 / 12 HIS A 293
GLU A 294
HIS A 297
TRP A 309
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
None
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.35A 4r7lA-4qmeA:
22.4		 4r7lA-4qmeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 TYR A 181
PRO A 118
GLU A 316
TYR A 372
 None
37B  A 901 ( 4.7A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.35A 4w5tA-4qmeA:
3.3		 4w5tA-4qmeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 10 VAL A  90
THR A  21
VAL A  88
LEU A  23
LEU A  51
 None
 1.06A 4yb6A-4qmeA:
undetectable
4yb6E-4qmeA:
undetectable		 4yb6A-4qmeA:
17.88
4yb6E-4qmeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 10 VAL A  90
THR A  21
VAL A  88
LEU A  23
LEU A  51
 None
 1.07A 4yb6B-4qmeA:
undetectable
4yb6C-4qmeA:
undetectable		 4yb6B-4qmeA:
17.88
4yb6C-4qmeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 10 LEU A  23
LEU A  51
VAL A  90
THR A  21
VAL A  88
 None
 1.06A 4yb6B-4qmeA:
undetectable
4yb6F-4qmeA:
undetectable		 4yb6B-4qmeA:
17.88
4yb6F-4qmeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 GLU A 119
THR A   4
HIS A   6
 None
 0.79A 4ydqB-4qmeA:
undetectable		 4ydqB-4qmeA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 TYR A 181
PRO A 118
GLU A 316
TYR A 372
 None
37B  A 901 ( 4.7A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.33A 4z4cA-4qmeA:
3.4		 4z4cA-4qmeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A 505
PHE A 455
LEU A 483
GLY A 448
LEU A 527
 None
 1.25A 4zbrA-4qmeA:
undetectable		 4zbrA-4qmeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 ILE A 338
LEU A 610
PHE A 607
THR A 565
 None
None
None
SO4  A 917 (-4.1A)
 1.01A 5b1aN-4qmeA:
3.0
5b1aW-4qmeA:
undetectable		 5b1aN-4qmeA:
19.71
5b1aW-4qmeA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.24A 5bxnH-4qmeA:
undetectable
5bxnI-4qmeA:
undetectable		 5bxnH-4qmeA:
14.50
5bxnI-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.23A 5bxnV-4qmeA:
undetectable
5bxnW-4qmeA:
undetectable		 5bxnV-4qmeA:
14.50
5bxnW-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.20A 5cz7V-4qmeA:
undetectable
5cz7W-4qmeA:
undetectable		 5cz7V-4qmeA:
14.38
5cz7W-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 LYS A 100
PHE A 815
VAL A 819
GLU A 775
 None
 1.13A 5dqyA-4qmeA:
undetectable		 5dqyA-4qmeA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 GLU A 260
ALA A 258
GLU A 294
GLU A 316
 37B  A 901 (-2.2A)
37B  A 901 (-3.8A)
37B  A 901 (-2.6A)
ZN  A 908 ( 2.0A)
 1.44A 5dwkC-4qmeA:
undetectable		 5dwkC-4qmeA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 ILE A 124
GLY A 120
ASN A 154
PHE A 183
THR A  21
 None
 1.34A 5fhzA-4qmeA:
undetectable		 5fhzA-4qmeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 ARG A 726
THR A 759
ASP A 758
 None
 0.59A 5g5gA-4qmeA:
0.0
5g5gB-4qmeA:
undetectable		 5g5gA-4qmeA:
14.20
5g5gB-4qmeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ILE A 861
GLY A 859
ASP A 813
PHE A 815
 None
 0.94A 5hieA-4qmeA:
undetectable		 5hieA-4qmeA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 1.03A 5kqyA-4qmeA:
undetectable		 5kqyA-4qmeA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.18A 5l5fH-4qmeA:
undetectable
5l5fI-4qmeA:
undetectable		 5l5fH-4qmeA:
14.38
5l5fI-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.18A 5l5fV-4qmeA:
undetectable
5l5fW-4qmeA:
undetectable		 5l5fV-4qmeA:
14.38
5l5fW-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.18A 5l66H-4qmeA:
undetectable
5l66I-4qmeA:
2.2		 5l66H-4qmeA:
14.38
5l66I-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 THR A 466
ALA A 439
GLY A 440
THR A 441
ASP A 622
 None
 1.18A 5l66V-4qmeA:
undetectable
5l66W-4qmeA:
undetectable		 5l66V-4qmeA:
14.38
5l66W-4qmeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 GLU A 117
PHE A 371
THR A 373
TYR A 372
 37B  A 901 (-2.5A)
None
None
37B  A 901 (-3.5A)
 1.18A 5lrbA-4qmeA:
undetectable		 5lrbA-4qmeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 4 GLU A  98
PRO A  96
ILE A  94
LEU A  95
 None
 1.33A 5m45D-4qmeA:
undetectable		 5m45D-4qmeA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 LYS A 123
LYS A 100
SER A 101
 None
 1.48A 5odiA-4qmeA:
undetectable		 5odiA-4qmeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 4 HIS A 297
HIS A 293
TYR A 377
GLU A 316
 ZN  A 908 ( 3.2A)
37B  A 901 ( 3.2A)
GOL  A 910 ( 2.6A)
ZN  A 908 ( 2.0A)
 1.41A 5pahA-4qmeA:
undetectable		 5pahA-4qmeA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 ASP A 430
LEU A 314
VAL A 412
ALA A 424
GLY A 426
 None
 1.10A 5uxdB-4qmeA:
0.2		 5uxdB-4qmeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 SER A 201
THR A 199
PHE A 197
VAL A 205
 None
IMD  A 911 ( 4.2A)
GOL  A 909 (-4.5A)
IMD  A 911 ( 4.4A)
 1.24A 5vkqA-4qmeA:
3.2
5vkqB-4qmeA:
3.1		 5vkqA-4qmeA:
20.39
5vkqB-4qmeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 SER A 201
THR A 199
PHE A 197
VAL A 205
 None
IMD  A 911 ( 4.2A)
GOL  A 909 (-4.5A)
IMD  A 911 ( 4.4A)
 1.21A 5vkqC-4qmeA:
3.2
5vkqD-4qmeA:
3.2		 5vkqC-4qmeA:
20.39
5vkqD-4qmeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 GLY A 292
ALA A 229
PHE A 246
ASN A 265
ASN A 154
 None
 1.16A 6bqgA-4qmeA:
2.0		 6bqgA-4qmeA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 LEU A  49
GLY A  64
PRO A  82
VAL A  81
ILE A  78
 None
 0.99A 6dgxB-4qmeA:
undetectable		 6dgxB-4qmeA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 VAL A  34
THR A  92
LEU A 185
ALA A  55
PHE A 121
 None
 1.25A 6dryA-4qmeA:
undetectable		 6dryA-4qmeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 THR A 725
ALA A 698
LYS A 700
 None
 0.76A 6fgcA-4qmeA:
undetectable		 6fgcA-4qmeA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		3 / 3 THR A 725
ALA A 698
LYS A 700
 None
 0.75A 6fgdA-4qmeA:
2.4		 6fgdA-4qmeA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 ILE A 128
GLU A  41
HIS A  17
VAL A 133
 None
 1.07A 6j20A-4qmeA:
undetectable		 6j20A-4qmeA:
20.00