SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		4 / 6 THR A 372
PHE A 325
PHE A  69
GLY A  61
 None
 1.12A 1icuC-4qmkA:
undetectable
1icuD-4qmkA:
undetectable		 1icuC-4qmkA:
15.74
1icuD-4qmkA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 ASN A 153
PHE A 239
VAL A 246
 None
 0.85A 1kijA-4qmkA:
undetectable		 1kijA-4qmkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 10 LEU A 495
VAL A 529
VAL A 549
GLY A 530
LEU A 491
 None
 1.48A 1lw0A-4qmkA:
undetectable		 1lw0A-4qmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 9 LEU A 495
VAL A 529
VAL A 549
GLY A 530
LEU A 491
 None
 1.28A 1lwfA-4qmkA:
undetectable		 1lwfA-4qmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 10 LEU A 175
ILE A 233
GLY A  90
GLY A  94
ILE A 176
 None
 0.93A 1sdtA-4qmkA:
undetectable		 1sdtA-4qmkA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 10 LEU A 175
ILE A 233
GLY A  90
GLY A  94
ILE A 176
 None
 0.93A 1sdvA-4qmkA:
undetectable		 1sdvA-4qmkA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 ASP A 240
GLU A 630
TYR A 613
 None
 0.76A 1wsvA-4qmkA:
undetectable		 1wsvA-4qmkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 11 LEU A 441
LEU A 448
ASN A 430
LEU A 458
ARG A 461
 None
 1.09A 2ceoA-4qmkA:
undetectable		 2ceoA-4qmkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		4 / 6 PRO A 163
LEU A 158
ARG A 164
GLY A 259
 None
 1.08A 2hs2B-4qmkA:
undetectable		 2hs2B-4qmkA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 585
ASN A 582
GLN A 587
ARG A 591
THR A 628
 None
 1.49A 2q7iA-4qmkA:
undetectable		 2q7iA-4qmkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		4 / 8 LEU A 593
ARG A 604
SER A 572
VAL A 610
 None
 0.94A 2qd5B-4qmkA:
2.2		 2qd5B-4qmkA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		4 / 7 ALA A 202
THR A 201
ALA A 204
PRO A 197
 None
 0.88A 2ql8A-4qmkA:
undetectable
2ql8B-4qmkA:
undetectable		 2ql8A-4qmkA:
11.32
2ql8B-4qmkA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 585
ASN A 582
GLN A 587
ARG A 591
THR A 628
 None
 1.38A 2yloA-4qmkA:
undetectable		 2yloA-4qmkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 LEU A 315
VAL A  30
ARG A  33
 None
 0.91A 3b0wB-4qmkA:
undetectable		 3b0wB-4qmkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 LEU A 117
GLU A 179
ILE A 176
 BME  A 700 ( 4.9A)
None
None
 0.58A 3czhA-4qmkA:
undetectable		 3czhA-4qmkA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 GLU A 319
SER A  50
VAL A  49
 None
 0.76A 3eeoA-4qmkA:
undetectable		 3eeoA-4qmkA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 ALA A  95
GLY A  90
GLY A  61
SER A  60
ALA A 261
 None
 1.12A 3ou6A-4qmkA:
undetectable		 3ou6A-4qmkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 ALA A  95
GLY A  90
GLY A  61
SER A  60
ALA A 261
 None
 1.12A 3ou6B-4qmkA:
undetectable		 3ou6B-4qmkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 ALA A  95
GLY A  90
GLY A  61
SER A  60
ALA A 261
 None
 1.12A 3ou7B-4qmkA:
undetectable		 3ou7B-4qmkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		6 / 11 LEU A  35
ALA A 432
ASP A 431
GLY A 454
VAL A  27
ILE A  37
 None
 1.15A 3oxxD-4qmkA:
undetectable		 3oxxD-4qmkA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 11 LEU A 185
GLY A 212
ALA A 213
ILE A 188
ILE A 184
 None
 0.88A 3s45B-4qmkA:
undetectable		 3s45B-4qmkA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		4 / 7 ILE A 264
PHE A 239
LYS A 142
GLY A 141
 None
 1.20A 3sj0X-4qmkA:
undetectable		 3sj0X-4qmkA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		4 / 7 LEU A 606
GLY A 594
GLU A 562
ALA A 596
 None
 0.82A 3tehB-4qmkA:
undetectable		 3tehB-4qmkA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 585
ASN A 582
GLN A 587
ARG A 591
THR A 628
 None
 1.35A 3zqtA-4qmkA:
undetectable		 3zqtA-4qmkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 501
LEU A 498
ASN A 497
LEU A 495
ALA A 494
 None
 1.22A 4fn9B-4qmkA:
undetectable		 4fn9B-4qmkA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 501
LEU A 498
ASN A 497
LEU A 495
ALA A 494
 None
 1.18A 4ltwA-4qmkA:
undetectable		 4ltwA-4qmkA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 606
GLY A 608
LEU A 585
VAL A 590
THR A 628
 None
 1.00A 4ok1A-4qmkA:
undetectable		 4ok1A-4qmkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 606
GLY A 608
LEU A 585
VAL A 590
THR A 628
 None
 0.94A 4olmA-4qmkA:
undetectable		 4olmA-4qmkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 11 LEU A 441
LEU A 448
ASN A 450
VAL A  30
ILE A  37
 None
 1.08A 4x20D-4qmkA:
undetectable		 4x20D-4qmkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 ARG A 206
THR A 214
ASP A 217
 None
 0.73A 5g5gA-4qmkA:
undetectable
5g5gB-4qmkA:
undetectable		 5g5gA-4qmkA:
17.16
5g5gB-4qmkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 ALA A 494
ASN A 497
LEU A 498
 None
 0.42A 5i1oC-4qmkA:
undetectable		 5i1oC-4qmkA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 158
ILE A 264
LEU A 172
PHE A 248
ALA A  93
 None
 1.04A 5j7wC-4qmkA:
undetectable		 5j7wC-4qmkA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		3 / 3 SER A  60
SER A  91
PHE A 366
 None
 0.62A 5mugA-4qmkA:
undetectable		 5mugA-4qmkA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 SER A  60
VAL A 247
GLY A 235
SER A  92
PHE A  69
 None
 1.12A 6a94A-4qmkA:
2.5		 6a94A-4qmkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 SER A  60
VAL A 247
GLY A 235
SER A  92
PHE A  69
 None
 1.13A 6a94B-4qmkA:
2.1		 6a94B-4qmkA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 LEU A 185
GLY A 212
ALA A 213
ILE A 188
ILE A 184
 None
 0.92A 6dh3A-4qmkA:
undetectable		 6dh3A-4qmkA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 VAL A  45
LEU A 458
ALA A 432
LEU A 441
LEU A  35
 None
 1.14A 6ew0F-4qmkA:
undetectable		 6ew0F-4qmkA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU
(Pseudomonas
fluorescens) 		5 / 12 VAL A  45
LEU A 458
ALA A 432
LEU A 441
LEU A  35
 None
 1.15A 6ew0G-4qmkA:
undetectable		 6ew0G-4qmkA:
9.45