SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4qn0 ENDONUCLEASE G,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 11 LEU A 149
ALA A 232
LEU A 210
PHE A 237
THR A 205
 None
 1.47A 3jwqB-4qn0A:
undetectable
3jwqC-4qn0A:
undetectable		 3jwqB-4qn0A:
20.68
3jwqC-4qn0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4qn0 ENDONUCLEASE G,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		4 / 8 GLU A  68
TYR A  74
ARG A 108
ASP A  85
 None
 1.14A 3mjrD-4qn0A:
undetectable		 3mjrD-4qn0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4qn0 ENDONUCLEASE G,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		4 / 6 ARG A 117
ASN A 154
GLY A 206
THR A 165
 None
 1.09A 4l1aB-4qn0A:
undetectable		 4l1aB-4qn0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4qn0 ENDONUCLEASE G,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		5 / 12 TYR A 202
ALA A 241
PHE A  86
HIS A 103
ILE A  69
 None
 1.14A 4rvgA-4qn0A:
undetectable		 4rvgA-4qn0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4qn0 ENDONUCLEASE G,
MITOCHONDRIAL
(Caenorhabditis
elegans) 		3 / 3 ARG A 193
LYS A 196
ARG A  65
 None
 0.88A 6c06D-4qn0A:
undetectable		 6c06D-4qn0A:
undetectable