SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		5 / 10 HIS A1073
ALA A1043
ASN A1028
ALA A1031
ILE A1035
 None
 0.89A 1likA-4qn1A:
undetectable		 1likA-4qn1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		5 / 12 LEU A1121
LEU A1338
PHE A1250
ALA A1210
ALA A1246
 None
 1.09A 1n5xA-4qn1A:
undetectable		 1n5xA-4qn1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		5 / 12 LEU A1121
LEU A1338
PHE A1250
ALA A1210
ALA A1246
 None
 1.08A 1n5xB-4qn1A:
2.2		 1n5xB-4qn1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		4 / 7 SER A1053
HIS A1057
THR A1400
LEU A1403
 None
 1.14A 3arrA-4qn1A:
undetectable		 3arrA-4qn1A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		4 / 4 THR A1063
LEU A1061
HIS A1057
GLY A1059
 None
 1.16A 5gwyA-4qn1A:
undetectable		 5gwyA-4qn1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		3 / 3 ALA A1210
ASN A1213
LEU A1214
 None
 0.41A 5i1oC-4qn1A:
undetectable		 5i1oC-4qn1A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens) 		3 / 3 ALA A1210
ASN A1213
LEU A1214
 None
 0.34A 5i1pA-4qn1A:
undetectable		 5i1pA-4qn1A:
6.85