SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.11A 1gtnB-4qn8A:
undetectable
1gtnC-4qn8A:
undetectable		 1gtnB-4qn8A:
18.12
1gtnC-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 GLY A  68
HIS A 112
ALA A 104
THR A  80
ALA A 107
 None
 1.12A 1gtnO-4qn8A:
undetectable
1gtnP-4qn8A:
undetectable		 1gtnO-4qn8A:
18.12
1gtnP-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4qn8 VIPE
(Legionella
pneumophila) 		3 / 3 THR A   4
PRO A   2
THR A   6
 None
 0.86A 316dC-4qn8A:
undetectable		 316dC-4qn8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 9 ILE A  22
PHE A 105
LEU A  17
LEU A 101
PHE A  36
 None
 1.31A 4qopA-4qn8A:
undetectable		 4qopA-4qn8A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 9 ILE A  22
PHE A 105
LEU A  17
LEU A 101
PHE A  36
 None
 1.30A 4qopB-4qn8A:
undetectable		 4qopB-4qn8A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 8 ILE A  22
PHE A 105
LEU A  17
LEU A 101
PHE A  36
 None
 1.31A 4qopC-4qn8A:
undetectable		 4qopC-4qn8A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eeuF-4qn8A:
undetectable
5eeuG-4qn8A:
undetectable		 5eeuF-4qn8A:
18.12
5eeuG-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 12 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eeuI-4qn8A:
undetectable
5eeuJ-4qn8A:
undetectable		 5eeuI-4qn8A:
18.12
5eeuJ-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eevF-4qn8A:
undetectable
5eevG-4qn8A:
undetectable		 5eevF-4qn8A:
18.12
5eevG-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 12 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eevI-4qn8A:
undetectable
5eevJ-4qn8A:
undetectable		 5eevI-4qn8A:
18.12
5eevJ-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eewF-4qn8A:
undetectable
5eewG-4qn8A:
undetectable		 5eewF-4qn8A:
18.12
5eewG-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 12 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eewI-4qn8A:
undetectable
5eewJ-4qn8A:
undetectable		 5eewI-4qn8A:
18.12
5eewJ-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eexF-4qn8A:
undetectable
5eexG-4qn8A:
undetectable		 5eexF-4qn8A:
18.12
5eexG-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eeyF-4qn8A:
undetectable
5eeyG-4qn8A:
undetectable		 5eeyF-4qn8A:
18.12
5eeyG-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5eezF-4qn8A:
undetectable
5eezG-4qn8A:
undetectable		 5eezF-4qn8A:
18.12
5eezG-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5ef0F-4qn8A:
undetectable
5ef0G-4qn8A:
undetectable		 5ef0F-4qn8A:
18.12
5ef0G-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.10A 5ef1F-4qn8A:
undetectable
5ef1G-4qn8A:
undetectable		 5ef1F-4qn8A:
18.12
5ef1G-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.11A 5ef2F-4qn8A:
undetectable
5ef2G-4qn8A:
undetectable		 5ef2F-4qn8A:
18.12
5ef2G-4qn8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4qn8 VIPE
(Legionella
pneumophila) 		5 / 10 ALA A 107
GLY A  68
HIS A 112
ALA A 104
THR A  80
 None
 1.11A 5ef3F-4qn8A:
undetectable
5ef3G-4qn8A:
undetectable		 5ef3F-4qn8A:
18.12
5ef3G-4qn8A:
18.12