SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		4 / 4 LYS A 149
LEU A 153
ALA A 114
LEU A 155
 None
 1.35A 1f86B-4qnnA:
undetectable		 1f86B-4qnnA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 9 ALA A 146
VAL A 109
GLY A 135
ILE A 134
ILE A 113
 None
 1.04A 1hpvB-4qnnA:
undetectable		 1hpvB-4qnnA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 12 ILE A 134
ILE A  49
MET A  65
ALA A  68
ARG A 132
 None
 1.45A 1ki7A-4qnnA:
undetectable		 1ki7A-4qnnA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 10 ALA A 146
VAL A 109
GLY A 135
ILE A 134
ILE A 113
 None
 0.96A 1muiA-4qnnA:
undetectable		 1muiA-4qnnA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		6 / 12 PHE A  53
GLY A 139
GLY A  52
VAL A 109
PHE A 145
ALA A 102
 None
 1.44A 1vq1B-4qnnA:
undetectable		 1vq1B-4qnnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 12 VAL A  46
ILE A  78
LEU A  76
ILE A  31
MET A 119
 None
 1.04A 2gj5A-4qnnA:
undetectable		 2gj5A-4qnnA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 11 ALA A 146
VAL A 109
GLY A 135
ILE A 134
ILE A 113
 None
 1.00A 2qhcA-4qnnA:
undetectable		 2qhcA-4qnnA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 12 LEU A 133
ILE A  80
ILE A  31
PHE A  48
PHE A  37
 None
 1.01A 2ygqA-4qnnA:
undetectable		 2ygqA-4qnnA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 9 ALA A 146
VAL A 109
GLY A 135
ILE A 134
ILE A 113
 None
 1.04A 3ektB-4qnnA:
undetectable		 3ektB-4qnnA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 9 ALA A 146
VAL A 109
GLY A 135
ILE A 134
ILE A 113
 None
 1.01A 3ekvB-4qnnA:
undetectable		 3ekvB-4qnnA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 10 ALA A 146
VAL A 109
GLY A 135
ILE A 134
ILE A 113
 None
 1.03A 4dqcA-4qnnA:
undetectable		 4dqcA-4qnnA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 9 GLY A 135
ILE A 161
GLY A 144
HIS A 141
ILE A 180
 None
 1.03A 4eatB-4qnnA:
2.9		 4eatB-4qnnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 11 GLY A 168
ALA A 167
ASP A 165
THR A 142
THR A 106
 None
 1.15A 4l1aA-4qnnA:
undetectable		 4l1aA-4qnnA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		4 / 4 ILE A 190
GLY A 135
ILE A 180
LEU A 164
 None
 0.88A 5dzkl-4qnnA:
undetectable
5dzkz-4qnnA:
undetectable		 5dzkl-4qnnA:
20.27
5dzkz-4qnnA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM
(Vespa
basalis) 		5 / 12 ASP A  81
HIS A  51
SER A 143
LEU A 133
ILE A 113
 None
 1.49A 6ccvC-4qnnA:
undetectable		 6ccvC-4qnnA:
13.37