SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4qns HISTONE
ACETYLTRANSFERASE
GCN5, PUTATIVE
(Plasmodium
falciparum) 		4 / 7 MET A1406
TYR A1457
ILE A1453
GLN A1450
 None
SO4  A1501 (-4.9A)
None
None
 0.95A 3hgxA-4qnsA:
undetectable		 3hgxA-4qnsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4qns HISTONE
ACETYLTRANSFERASE
GCN5, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 MET A1406
TYR A1457
ILE A1453
GLN A1450
 None
SO4  A1501 (-4.9A)
None
None
 0.96A 3remA-4qnsA:
undetectable		 3remA-4qnsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4qns HISTONE
ACETYLTRANSFERASE
GCN5, PUTATIVE
(Plasmodium
falciparum) 		4 / 8 MET A1406
TYR A1457
ILE A1453
GLN A1450
 None
SO4  A1501 (-4.9A)
None
None
 0.92A 3remB-4qnsA:
undetectable		 3remB-4qnsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4qns HISTONE
ACETYLTRANSFERASE
GCN5, PUTATIVE
(Plasmodium
falciparum) 		4 / 6 PRO A1380
VAL A1385
TYR A1393
ASN A1436
 None
 0.40A 5pbeA-4qnsA:
17.2		 5pbeA-4qnsA:
27.54