SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 ASP A 152
GLY A 132
ASP A 128
ILE A 181
GLY A 197
 None
None
None
SO4  A 402 (-4.0A)
SO4  A 401 (-3.3A)
 0.83A 1hshC-4qnxA:
undetectable		 1hshC-4qnxA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 ASP A 152
GLY A 132
ASP A 128
ILE A 181
GLY A 197
 None
None
None
SO4  A 402 (-4.0A)
SO4  A 401 (-3.3A)
 0.92A 1sguB-4qnxA:
undetectable		 1sguB-4qnxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
ASP A 152
THR A 154
GLU A 182
HIS A 201
 None
None
None
SO4  A 404 (-4.7A)
None
 0.83A 2gluA-4qnxA:
16.8		 2gluA-4qnxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.81A 2gluA-4qnxA:
16.8		 2gluA-4qnxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 ASP A 152
GLY A 132
ASP A 128
ILE A 181
GLY A 197
 None
None
None
SO4  A 402 (-4.0A)
SO4  A 401 (-3.3A)
 0.92A 2hs1A-4qnxA:
undetectable		 2hs1A-4qnxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 7 GLY A 231
ALA A 255
ALA A 257
VAL A 275
 None
 0.74A 3a2qA-4qnxA:
undetectable		 3a2qA-4qnxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 LEU A 156
PHE A  94
ALA A 163
MET A 289
THR A 286
 None
 1.07A 3c6gA-4qnxA:
undetectable		 3c6gA-4qnxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 11 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.75A 3g88A-4qnxA:
11.1		 3g88A-4qnxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 11 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.74A 3g88B-4qnxA:
11.6		 3g88B-4qnxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.80A 3g89A-4qnxA:
11.3		 3g89A-4qnxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 11 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.83A 3g89B-4qnxA:
11.4		 3g89B-4qnxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.78A 3g8bA-4qnxA:
11.4		 3g8bA-4qnxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
GLY A 132
ASP A 152
THR A 154
GLU A 182
 None
None
None
None
SO4  A 404 (-4.7A)
 0.84A 3g8bB-4qnxA:
11.6		 3g8bB-4qnxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 6 LEU A 227
PRO A 253
LEU A 318
LEU A 224
 None
 0.85A 3q1eA-4qnxA:
undetectable
3q1eC-4qnxA:
undetectable		 3q1eA-4qnxA:
18.04
3q1eC-4qnxA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 6 LEU A 318
LEU A 224
LEU A 227
PRO A 253
 None
 0.98A 3q1eA-4qnxA:
undetectable
3q1eC-4qnxA:
undetectable		 3q1eA-4qnxA:
18.04
3q1eC-4qnxA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 5 GLY A 150
ASP A 128
GLN A 160
MET A  83
 None
 1.22A 3qx3B-4qnxA:
undetectable		 3qx3B-4qnxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 9 ASP A 152
GLY A 132
ASP A 128
ILE A 181
GLY A 197
 None
None
None
SO4  A 402 (-4.0A)
SO4  A 401 (-3.3A)
 0.93A 3s53A-4qnxA:
undetectable		 3s53A-4qnxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
GLY A 132
ASP A 152
ILE A 181
HIS A 201
 None
None
None
SO4  A 402 (-4.0A)
None
 0.63A 4iv8A-4qnxA:
18.5		 4iv8A-4qnxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 GLY A 130
GLY A 132
ASP A 152
ILE A 181
HIS A 201
 None
None
None
SO4  A 402 (-4.0A)
None
 0.59A 4iv8B-4qnxA:
18.5		 4iv8B-4qnxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 8 HIS A 146
ARG A 173
LEU A 147
ILE A  11
 None
 0.88A 4k0bA-4qnxA:
undetectable		 4k0bA-4qnxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		3 / 3 VAL A 307
GLY A 309
LYS A 305
 None
 0.78A 4k50A-4qnxA:
undetectable		 4k50A-4qnxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		3 / 3 VAL A 307
GLY A 309
LYS A 305
 None
 0.75A 4k50E-4qnxA:
undetectable		 4k50E-4qnxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		3 / 3 VAL A 307
GLY A 309
LYS A 305
 None
 0.77A 4k50I-4qnxA:
undetectable		 4k50I-4qnxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		3 / 3 GLU A 282
TRP A 109
LYS A 314
 None
 1.09A 4k7aA-4qnxA:
undetectable		 4k7aA-4qnxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 8 HIS A 146
ARG A 173
LEU A 147
ILE A  11
 None
 0.91A 4l7iA-4qnxA:
undetectable		 4l7iA-4qnxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 11 LEU A  86
VAL A  99
LEU A  49
LEU A 167
ALA A 163
 None
 1.16A 4p65B-4qnxA:
undetectable
4p65D-4qnxA:
undetectable
4p65G-4qnxA:
undetectable
4p65H-4qnxA:
undetectable		 4p65B-4qnxA:
7.74
4p65D-4qnxA:
7.74
4p65G-4qnxA:
6.85
4p65H-4qnxA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 10 ASP A 152
GLY A 132
ASP A 128
ILE A 181
GLY A 197
 None
None
None
SO4  A 402 (-4.0A)
SO4  A 401 (-3.3A)
 0.94A 4q1yA-4qnxA:
undetectable		 4q1yA-4qnxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		6 / 12 GLY A 130
GLY A 132
ASP A 152
PRO A 153
ILE A 181
GLU A 182
 None
None
None
None
SO4  A 402 (-4.0A)
SO4  A 404 (-4.7A)
 0.59A 5bw4A-4qnxA:
11.7		 5bw4A-4qnxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		3 / 3 ASP A 152
GLU A 182
SER A 107
 None
SO4  A 404 (-4.7A)
None
 0.86A 5bw4B-4qnxA:
11.3		 5bw4B-4qnxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 PRO A 153
GLY A 150
GLY A 130
GLY A 180
LEU A 179
 None
 0.96A 5c0oG-4qnxA:
12.3		 5c0oG-4qnxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		5 / 12 ASP A 152
GLY A 132
ASP A 128
ILE A 181
GLY A 197
 None
None
None
SO4  A 402 (-4.0A)
SO4  A 401 (-3.3A)
 0.88A 5t8hA-4qnxA:
undetectable		 5t8hA-4qnxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE
(Escherichia
coli) 		4 / 5 GLY A 132
ARG A  90
ASP A 152
GLN A 183
 None
None
None
SO4  A 403 (-4.2A)
 1.47A 5ubbA-4qnxA:
14.3		 5ubbA-4qnxA:
20.19